Influence of Agrobacterium oncogenes on secondary metabolism of plants

Matveeva, T. V.; Сокорнова, С. В.; Лутова, Л. А.

doi:10.1007/s11101-015-9409-1

Cited by 34 publications

(17 citation statements)

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“…Formation and growth of HRs are the consequences of excessive biosynthesis of endogenous auxins and cytokinins and enhanced sensitivity of transformed plant cells to these hormones, and rol genes appear to play a critical role in these processes (Hashem 2009). Gene rolA has a promoter region similar to those of some auxinregulated genes, and its product is probably a DNA binding protein and stimulator of growth (Matveeva et al 2015). Primary studies proposed that rolB protein is a β-glucosidase releasing auxin (IAA) from its inactive conjugated forms, thus increasing auxin sensitivity (Esruch et al 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Primary studies proposed that rolB protein is a β-glucosidase releasing auxin (IAA) from its inactive conjugated forms, thus increasing auxin sensitivity (Esruch et al 1991). Moreover, the rolB geneencoded product was shown to exhibit tyrosine phosphatase activity (Filippini 1996;Dilshad et al 2015) and to interact with 14-3-3 proteins (Moriuchi et al 2004;Matveeva et al 2015), thus taking part in auxin signaling, enhancing the sensitivity of transformed cells toward auxin. It has been suggested that the product of rolC gene is a glucosidase liberating cytokinins from their bound forms (Estruch et al 1991;Rangslang et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Besides, the individual or combined rol genes are recognized to be an e cient activator of secondary metabolites biosynthesis in plants (Sarkar et al 2018). Products of these genes can activate the biosynthesis of different types of secondary metabolites in transgenic HRs, including alkaloids, anthraquinones, iso avonoids, and ginsenosides (Bulgakov et al 2013;Matveeva et al 2015).…”

Section: Discussionmentioning

confidence: 99%

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Elicitor-induced phenolic acids accumulation in Salvia virgata Jacq. hairy root cultures

Dowom

Abrishamchi

Radjabian

et al. 2021

Plant Cell Tiss Organ Cult

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Phenolic acids, as the predominant secondary metabolites of Salvia species, are largely used in pharmaceutical industries. The main aim of the study was to establish hairy root cultures of Salvia virgata Jacq. Also, the effects of methyl jasmonate (22.4 and 11.2 ppm), Ag + ions (5 and 2.5 ppm), and yeast extract (100 and 50 ppm) were assessed on total phenol, total avonoid, rosmarinic acid, salvianolic acid A, and caffeic acid contents in the hairy roots after 1, 3 and 5 days of exposure. Results showed the used Agrobacterium rhizogenes strains (A4, ATCC15834, R1000, GM1534, and C58C1) differed in their ability to induce hairy roots on leaf explants. The transformed roots were molecularly con rmed using rolC gene and the highest transformation frequency (56 %) was obtained by ATCC 15834 strain. Among the established hairy root lines, the highest amount of rosmarinic acid (0.45 ± 0.01 mg/g DW) and dry root biomass (2.29 ± 0.04 g) was obtained in AT3, the line which was induced by ATCC 15834 strain. The maximum accumulation of total phenol (123.6 ± 0.93 mg GAE/g DW), total avonoid (5.09 ± 0.07 mg QUE/g DW), rosmarinic acid (18.45 ± 0.8 mg/g DW), salvianolic acid A (2.11 ± 0.04 mg/g DW) and caffeic acid (2.61 ± 0.02 mg/g DW) was observed in the hairy roots elicited with 22.4 ppm methyl jasmonate on day three after treatment. The results support that elicitation could be an effective procedure for the improvement of caffeic acid derivatives production in S. virgata hairy root cultures.Furthermore, it has shown that RA and Sal-B could improve memory and cognitive impairment related to Alzheimer's disease (Shen et al. 2017;Gok et al. 2018). Chemically, CA is the basic structural unit of phenolic acids in Salvia species. Rosmarinic acid is an ester of CA and 3, 4-dihydroxyphenyllactic acid, and Sal-B is identi ed as a dimmer of RA (Wang et al. 2019) (Fig. 1).Biosynthesis of phenolic acids occurs mainly via the phenylpropanoid and tyrosine-derived pathways (Di et al. 2013). Many of the encoding genes for the critical enzymes in the biosynthetic pathways of phenolic acids, including phenylalanine ammonia-lyase (PAL), cinnamic acid 4-hydroxylase (C4H), hydroxycinnamate coenzyme A ligase (4CL), tyrosine aminotransferase (TAT), 4-hydroxyphenylpyruvate reductase (HPPR), rosmarinic acid synthase (RAS), and a cytochrome P450-dependent monooxygenase (CYP98A14), were identi ed in S. miltiorrhiza (Di et al. 2013;Zhang et al. 2014;Wang et al. 2015;Xing et al. 2018b).Due to the genetic stability, large biomass output, and high biosynthetic capacity, hairy root (HR) culture is considered as an alternative technique for secondary metabolite production, compared to native plant roots and cell/callus cultures (Hu and Du 2006;Ono and Tian 2011). Moreover, the application of HR cultures in many industrial and scienti c elds, including designing of bioreactors, recombinant protein production, phytoremediation, and metabolic and genetic engineering, has been reported (Ashihara et al. 2011;Doran 2013; Kuma 2018).It has demonstrated that the ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Elicitor-induced phenolic acids accumulation in Salvia virgata Jacq. hairy root cultures

Dowom

Abrishamchi

Radjabian

et al. 2021

Plant Cell Tiss Organ Cult

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“…Plants produce many diverse compounds which include anthraquinones, saponins, flavonoids, alkaloids, anthocyanins and terpenes which play an important role in various industries (Tian, 2015). Many of these compounds are produced by plants through secondary metabolism; these metabolites are usually non-essential for the growth of plants, hence the amount produced is often quite low (Kim;Wyslouzi;Weathers, 2002;Matveeva;Sokornova;Lutova, 2015).…”

Section: Role Of Rol Genes On Plant Secondary Metabolismmentioning

confidence: 99%

Agrobacterium spp. genes and ORFs: Mechanisms and applications in plant science

et al. 2018

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The bacterial origin of crown gall tumours, Agrobacterium tumefaciens was isolated 100 years ago. 70 years later, the findings that random integration of bacterial DNA into the host plant genome provided the potential of using Agrobacterium as a plant genetic engineering tool. Since the 1980s, Agrobacterium-mediated transformation on wide range of plants began developing rapidly. This review focused on the oncogenes of A. rhizogenes which is the causative agent of the hairy root disease and the application of A.rhizogenes in plant science.

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“…Transgenic hairy root culture have revolutionized the role of tissue culture of plants in the production of secondary metabolites. Matveeva et al (2015) summarized the influence of agrobacterium oncogenes on secondary metabolites of plants.…”

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confidence: 99%

Phytochemicals in medicine and food

Xiao

2015

Phytochem Rev

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Influence of Agrobacterium oncogenes on secondary metabolism of plants

Cited by 34 publications

References 100 publications

Elicitor-induced phenolic acids accumulation in Salvia virgata Jacq. hairy root cultures

Elicitor-induced phenolic acids accumulation in Salvia virgata Jacq. hairy root cultures

Agrobacterium spp. genes and ORFs: Mechanisms and applications in plant science

Phytochemicals in medicine and food

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