Influence of additives on a thermosensitive hydrogel for buccal delivery of salbutamol: Relation between micellization, gelation, mechanic and release properties

Zeng, Ni; Dumortier, G.; Maury, Marc; Mignet, Nathalie; Boudy, Vincent

doi:10.1016/j.ijpharm.2014.03.055

Cited by 61 publications

(40 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Formulations composed of 20% (w/w) P407 and Carbopol ® 934P exhibited pronounced high elasticity and mucoadhesive properties at body temperature [146]. Hydrogels were also proposed as delivery systems for systemic absorption of drugs extensively metabolized via the oral route [147,148]. The chemical enhancer dodecyl-2-(N,N-dimethylamino)propionate hydrochloride and the iontophoresis technique significantly increased the transbuccal delivery of ondansetron hydrochloride loaded in 1% CMC hydrogel, through porcine buccal tissue without major morphological changes in the tissue itself.…”

Section: Semisolid Dosage Forms: Hydrogelsmentioning

confidence: 99%

A focus on mucoadhesive polymers and their application in buccal dosage forms

Russo

Selmin

Baldassari

et al. 2016

Journal of Drug Delivery Science and Technology

137

View full text Add to dashboard Cite

Section: Semisolid Dosage Forms: Hydrogelsmentioning

confidence: 99%

A focus on mucoadhesive polymers and their application in buccal dosage forms

Russo

Selmin

Baldassari

et al. 2016

Journal of Drug Delivery Science and Technology

137

View full text Add to dashboard Cite

“…This setup is widely employed for in vitro drug release testing from ocular inserts [50] and contact lenses [51]. Sometimes is also used in case of semisolid dosage forms [6], microparticles for nasal application [52] and thermosensitive gels for buccal application [53]. This apparatus allows the drug release testing under physiological flow rate of the dissolution medium and offers ability to maintain the sink conditions while operating in an open system setup.…”

Section: Membrane Diffusion Methodsmentioning

confidence: 99%

In vitro dissolution/release methods for mucosal delivery systems

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The study of erosion phenomenon using a flow through apparatus showed promising results in the prediction of in vivo retention time [18]. Flow through apparatus is now extensively used for in vitro drug release tests from ophthalmic dosage forms allowing the testing under pseudo-physiological conditions in term of flow rate and release medium ratio [19].…”

Section: In Vitro Drug Release Study Using the Usp 4 Apparatusmentioning

confidence: 99%

“…Previous work from our group already emphasized the use of the Peppas-Sahlin model to quantify the contribution of diffusion and erosion in the drug release of a thermosensitive in situ gelling delivery system [18,31]. The Peppas-Sahlin equation can be transformed.…”

Section: Erosion Dependent Release Not Influenced By Diffusionmentioning

confidence: 99%

In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics

Destruel

Zeng²,

Brignole-Baudouin

et al. 2020

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Mydriasis is required prior to many eye examinations and ophthalmic surgeries. Nowadays, phenylephrine hydrochloride (PHE) and tropicamide (TPC) are extensively used to induce mydriasis. Several pharmaceutic dosage forms of these two active ingredients have been described. However, no optimal therapeutic strategy has reached the market. The present work focuses on the formulation and evaluation of a mucoadhesive ion-activated in situ gelling delivery system based on gellan gum and hydroxyethylcellulose (HEC) for the delivery of phenylephrine and tropicamide. First, in vitro drug release was studied to assess appropriate sustained drug delivery on the ocular surface region. Drug release mechanisms were explored and explained using mathematical modeling. Then, in situ gelling delivery systems were visualized using scanning electron microscopy illustrating the drug release phenomena involved. Afterward, cytotoxicity of the developed formulations was studied and compared with those of commercially available eye drops. Human epithelial corneal cells were used. Finally, mydriasis intensity and kinetic was investigated in vivo. Mydriasis pharmacodynamics was studied by non-invasive optical imaging on vigilant rabbits, allowing eye blinking and nasolacrimal drainage to occur physiologically. In situ gelling delivery systems mydriasis profiles exhibited a significant increase of intensity and duration compared with those of conventional eye drops. Efficient mydriasis was achieved following the administration of a single drop of in situ gel reducing the required amount of administered active ingredients by four-to eight-fold compared with classic eye drop regimen.

show abstract

Influence of additives on a thermosensitive hydrogel for buccal delivery of salbutamol: Relation between micellization, gelation, mechanic and release properties

Cited by 61 publications

References 48 publications

A focus on mucoadhesive polymers and their application in buccal dosage forms

A focus on mucoadhesive polymers and their application in buccal dosage forms

In vitro dissolution/release methods for mucosal delivery systems

In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics

Contact Info

Product

Resources

About