A focus on mucoadhesive polymers and their application in buccal dosage forms

Russo, Eleonora; Selmin, Francesca; Baldassari, Sara; Gennari, C.; Caviglioli, Gabriele; Minghetti, Paola; Parodi, Brunella

doi:10.1016/j.jddst.2015.06.016

Cited by 134 publications

(76 citation statements)

References 147 publications

(150 reference statements)

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“…It has been suggested that polymers containing carboxyl groups are better than sulfated polymers for the encapsulation and controlled release of drugs [20]. All polyanions used in the investigation have carboxyl groups [20,21].…”

Section: Resultsmentioning

confidence: 99%

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Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Henao

Delgado

Contreras

et al. 2018

International Journal of Chemical Engineering

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e preparation of gels by charge interaction methods has been extensively studied, but it is not yet clear how these methods influence gel characteristics. e objective of this work was to study differences in morphology and surface charge of hydrogels prepared by ionotropic gelation, polyelectrolyte complexation, and a combination of both methods. us, the anionic charge was provided by carboxymethylcellulose (CMC), carboxymethylated starch (CMS), and alginic acid (AA); calcium chloride (CaCl 2 ) and chitosan (CS) were used for the ionotropic gelation and polyelectrolyte complexation, respectively. ose materials are commercially available, have low toxicity, and are widely used in the area. ese compounds interact through physical crosslinks, which are affected by physical changes of the medium. Our results showed that these two methods produced changes in the morphology of the hydrogels. CMC gels exhibited larger pores in the presence of CaCl 2 . In polyelectrolyte complexation, CMS produced an increased agglomeration of particles, while the addition of CaCl 2 to AA generated dispersed particles of size in the order of millimeters. Mixing both ionotropic gelation and polyelectrolyte complexation methods yielded gels of varied charge (568 mV for CMC, 502 mV for CMS, and 1713 mV for AA). FTIR spectra of the hydrogels showed interactions between the different polymeric compounds, being the greatest changes between 1250 and 1600 cm −1 , due possibly to the replacement of Na by Ca at crosslinking points. erefore, the method of gel preparation employed had a major influence on the size and pore distribution, parameters which in turn influence encapsulation and drug delivery in these systems.

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Section: Resultsmentioning

confidence: 99%

“…All polyanions used in the investigation have carboxyl groups [20,21]. e mixture of the different polyanions with the CS produced a hydrogel at a pH lower than 4, and the morphology of hydrogels is very sensitive to the preparation procedures [16,22,23].…”

Section: Resultsmentioning

confidence: 99%

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Henao

Delgado

Contreras

et al. 2018

International Journal of Chemical Engineering

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“…Solid dispersion of domperidone using beta-cyclodextrin, PEG400 and HPMC E15 was successfully prepared and films were casted using solid dispersion extrusion method. [9,10] Rolling Method [11,12] :…”

Section: Solid Dispersion Extrusion Methodmentioning

confidence: 99%

A Review on Mouth Dissolving Film

Pawar¹,

Sharma²,

Sharma³

et al. 2019

J. Drug Delivery Ther.

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Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. This dosage form allows the medication to bypass the first pass metabolism so bioavailability of medication may be improved .Mouth dissolving film has potential to improve onset of action lower the dosing and eliminate the fear of chocking. Formulation of mouth dissolving films involves both the visual and performance characteristics as plasticized hydrocolloids, API taste masking agents are being laminated by solvent casting and semisolid casting method. Solvent casting method being the most preferred method over other methods because it offers great uniformity of thickness and films prepared having fine glossy look and better physical properties. Mouth dissolving films are evaluated for its various parameters like thickness, physical property like folding endurance, disintegration and dissolution time. This review gives an idea about formulation techniques, evaluation parameters, overview on packaging and some available marketed products of mouth dissolving films. Keywords: Mouth dissolving film, solvent casting, fast disintegration

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“…As stated by Chatterjee and his colleagues in 2017, the success of mucoadhesive formulations depends on the ability of the polymer/s to retain at the mucous layer and to sustain the drug release [44]. Mucoadhesive formulations contain at least one hydrophilic polymer, when this polymer comes in contact to saliva, due to the aqueous nature of saliva, it is wetted, and simultaneously adheres to the mucous with some physical interaction [38]. The polymers employed in BNZ-PLGA-NPs-HG formulations have been denoted as mucoadhesive and, therefore, it would be anticipated that the formulation would display good adherence properties [39][40].…”

Section: Mucoadhesion Studymentioning

confidence: 99%

Plga Nanoparticles Loaded Mucoadhesive and Thermosensitive Hydrogel as a Potential Platform for the Treatment of Oral Mucositis

El-Feky¹,

Zayed

2019

Int J App Pharm

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Objective: The objective of this study was to design an effective topical treatment for oral mucositis.Methods: Poly-(DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) and Poloxamer407 (PLX)/Hydroxy propyl methyl cellulose (HPMC) hydrogel matrix (HG) were used as combined carriers for benzydamine HCL (BNZ). BNZ loaded PLGA nanoparticles were assessed for their particle size, PDI, zeta potential and entrapment efficiency. Scanning electron microscopy, thermosensitivity study, mucoadhesion study, in vitro release and in vivo investigation were used to characterize the combined BZN loaded PLGA NPs HG.Results: Negatively charged NPs with an average diameter of 139±4.92 nm were incorporated into PLX/HPMC HG bases. The gelation temperature of BZN-PLGA-NPs-HGs ranged between 31°C and 36.5°C. When diluted with saliva simulated fluid, BZN-PLGA-NPs-HGs preserved their gelation properties. Mucoadhesion was found lower for formulations prepared with PLX without HPMC. An increase in the concentrations of PLX from 10 to 30% resulted in an increase in adhesion. Both PLGA-NPs and PLGA-NPs-HG provided a biphasic drug release profile while BZN-HG provided monophasic zero order release pattern. The in vivo study showed that animal groups treated with BZN-HG and BZN-PLGA-NPs-HG showed a significantly higher reduction percentage in ulcer surface area compared to those treated with BZN-PLGA-NPs. BZN-PLGA-NPs-HG group needed 10 d of treatment to complete healing versus 16 d, 14 d and 12 d for the complete healing of groups with no treatment, treated with BZN-PLGA-NPs and treated with BZN-HG, respectively.Conclusion: BZN-PLGA-NPs-HG could represent a promising mean for the effective treatment of oral mucositis induced by cancer therapy.

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A focus on mucoadhesive polymers and their application in buccal dosage forms

Cited by 134 publications

References 147 publications

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

A Review on Mouth Dissolving Film

Plga Nanoparticles Loaded Mucoadhesive and Thermosensitive Hydrogel as a Potential Platform for the Treatment of Oral Mucositis

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