Inflammatory mediators in morbidly obese subjects: associations with glucose abnormalities and changes after oral glucose

Abstract

Objective: To explore inflammatory mediators in morbidly obese (MO) subjects with various categories of glucose tolerance and to study the changes in these mediators after an oral glucose load. Design: Cross-sectional and experimental study. Methods: A total of 144 MO subjects were classified into three categories: normal glucose tolerance (NGT); pre-diabetes; and new onset diabetes mellitus (NODM) were included, as were 27 normal weight normoglycemic controls. Serum osteoprotegerin (OPG), visfatin, leptin, adiponectin, interleukin-1 receptor antagonist (IL-1Ra), and C-reactive protein (CRP) were analyzed during an oral glucose tolerance test (OGTT). Results: Fasting levels of leptin and IL-1Ra were consistently higher in obese persons (P!0.001 and P!0.05). MO subjects with NGT had higher CRP levels (P!0.001) and lower adiponectin levels (P!0.05) compared to controls. Yet when compared with MO subjects with NODM, those with NGT had lower CRP levels and higher adiponectin levels (both P!0.05). Baseline OPG and visfatin levels did not differ between the groups (PZ0. 326 and PZ0.198). During OGTT, OPG levels decreased (P!0.001) and visfatin levels increased transiently (PZ0.018). The response in OPG and visfatin did not differ between the groups (PZ0.690 and PZ0.170). There were minor changes in adiponectin and leptin levels. Conclusions: Morbid obesity and glucose intolerance were associated with lower adiponectin levels and higher CRP levels, thus supporting a relationship between obesity, glucose homeostasis, and inflammation. Oral glucose suppressed OPG levels and transiently enhanced visfatin levels independent of obesity and glucose tolerance status, indicating that glucose may be involved in the acute regulation of these proteins.

CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

“…The observed increase in CRP levels reported in patients with morbid obesity is consistent with the studies of Hofso et al (2009), van Dielen et al (2001, and Solá et al (2009). In patients with morbid obesity there was a positive correlation between the concentration of CRP and BMI before the BT, which is in line with the results reported by Visser et al (1999).…”

Circulating levels of novel adipocytokines in patients with colorectal cancer

“…The concentration of circulating visfatin in relation to obesity is controversial [31][32][33]. In a recent study [34], PBEF1/Nampt/Visfatin mRNA levels were not correlated with measures of obesity, and the researchers suggested that visfatin is not predominantly secreted from visceral fat.…”

Impact of gender on vitamin D deficiency in morbidly obese patients: a cross-sectional study

“…The remaining 2026 patients were included in the analysis. In addition, a subgroup of 154 patients (Hofso et al, 2009b) examined between December 2005 and May 2006 was evaluated in order to assess total vitamin D intake and macronutrient composition. All patients gave written consent before enrollment and the study was approved by the Regional Committee for Medical Research Ethics and conducted in accordance with the Declaration of Helsinki (World Medical Association, 1997).…”