CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Rość, Danuta; Adamczyk, Przemysław; Boińska, Joanna; Szafkowski, Robert; Ponikowska, Irena; Stankowska, Katarzyna; Góralczyk, Barbara; Ruszkowska-Ciastek, Barbara

doi:10.1631/jzus.b1400219

Cited by 24 publications

(21 citation statements)

References 23 publications

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“…Another study showed an improvement of the inflammatory profile of obese patients who consumed a low-calorie diet and had a weight loss of 9% after 21 days, but it did show any important decrease in TNF-α [ 44 ]. Additionally, the authors suggested removing fatty tissue to reach a better result of TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases

et al. 2018

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BackgroundObesity is a worldwide disease related to genetic, environmental, and behavioral factors, and it is associated with high rates of morbidity and mortality. Recently, obesity has been characterized by a low-grade inflammatory state known as inflammome indicated by chronic increases in circulating concentrations of inflammatory markers. The purpose of this study was to evaluate the effect of weight loss induced by surgery for obesity and weight-related diseases on pro-inflammatory cytokine (TNF-α) and anti-inflammatory adipokine (adiponectin) levels, and on an adipose-derived hormone (leptin) in severely obese subjects.MethodsThis randomized, controlled trial involved 55 severe obese patients (50 women, age 18–63 years, and body mass index of 35.7–63 kg/m2) who underwent bariatric surgery (BS). Patients with a BMI > 65 kg/m2 and clinical and mental instability, or significant and unrealistic expectations of surgery were excluded. Blood samples were collected during the fasting period to analyze tumor necrosis factor alpha (TNF-α), adiponectin, and leptin levels by enzyme-linked immunosorbent assay.ResultsAt baseline, no significant difference was observed in the anthropometric, demographic, clinical characteristics and biochemistry and inflammatory markers between the control group (CG) and bariatric surgery group (BSG). The same finding was also observed when we compared the baseline variables to those at the 6-month follow-up in the CG. However, the same variables in the BSG group were significantly different between baseline and the 6-month follow-up after BS.ConclusionsWeight loss induced by surgery for obesity and weight-related diseases reduced the inflammome state in severely obese patients.

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Section: Discussionmentioning

confidence: 99%

Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases

et al. 2018

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“…Obesity is a major factor associated with elevated CRP in individuals with the metabolic syndrome [30], and CRP decreases after weight loss in obese subjects [31]. Harborne et al .…”

Section: Discussionmentioning

confidence: 99%

Impact of metformin on C-reactive protein levels in women with polycystic ovary syndrome: a meta-analysis

Chen

Deng³

et al. 2017

Oncotarget

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The impact of the recommended first-line treatment with metformin on C-reactive protein (CRP) levels in patients with polycystic ovary syndrome (PCOS) is still controversial. We conducted a meta-analysis of studies reporting the impact of metformin on serum CRP levels in women with PCOS. The weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs) were used to assesse the effects. GRADE approach was used to assesse the quality of the evidence. A total of 20 studies that included 433 women with PCOS were analyzed. CRP levels significantly decreased after metformin treatment (WMD = -1.23mg/L, 95%CI: -1.65 to -0.81, I2 = 93% and P < 0.001 for heterogeneity). The decreased levels of CRP were observed both in lean (BMI<25 kg/m2) and obese (BMI>25 kg/m2) patients. Interestingly, the degree of decreased CRP levels was not depended on metformin dosage, but more significantly in patients treated beyond 6 months (WMD≥6months = -1.47mg/L vs. WMD<6months = -0.94 mg/L). Decreased CRP levels are not associated with the status of IR and androgen in patients with PCOS. However, the quality of evidence was very low because of the limitations and inconsistency of the included studies. Therefore, metformin shows the potential effects on CRP levels in women with PCOS. However, considering the very low quality of evidence for the analysis, the effect of metformin on CRP levels are still very uncertain, and large-scale randomized-controlled study is needed to ascertain the long-term effects of metformin in PCOS.

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“…Circulating concentrations of CRP, TNF-α, and IL-6 are generally elevated in participants with insulin resistance and obesity (18)(19)(20). Weight loss has been shown to decrease concentrations of these proinflammatory factors and improve insulin sensitivity (21)(22)(23). Very few studies have examined the impact of intermittent fasting versus daily CR on inflammatory mediators (5,7,8).…”

Section: Wwwobesityjournalorgmentioning

confidence: 99%

Differential Effects of Alternate‐Day Fasting Versus Daily Calorie Restriction on Insulin Resistance

Gabel

Kroeger

Trepanowski

et al. 2019

Obesity

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Objective This study compared the effects of alternate‐day fasting (ADF) with those of daily calorie restriction (CR) on body weight and glucoregulatory factors in adults with overweight or obesity and insulin resistance. Methods This secondary analysis examined the data of insulin‐resistant individuals (n = 43) who participated in a 12‐month study that compared ADF (25% energy needs on “fast days”; 125% energy needs on alternating “feast days”) with CR (75% energy needs every day) and a control group regimen. Results In insulin‐resistant participants, weight loss was not different between ADF (−8% ± 2%) and CR (−6% ± 1%) by month 12, relative to controls (P < 0.0001). Fat mass and BMI decreased (P < 0.05) similarly from ADF and CR. ADF produced greater decreases (P < 0.05) in fasting insulin (−52% ± 9%) and insulin resistance (−53% ± 9%) compared with CR (−14% ± 9%; −17% ± 11%) and the control regimen by month 12. Lean mass, visceral fat mass, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, triglycerides, blood pressure, C‐reactive protein, tumor necrosis factor α, and interleukin 6 values remained unchanged. Conclusions These findings suggest that ADF may produce greater reductions in fasting insulin and insulin resistance compared with CR in insulin‐resistant participants despite similar decreases in body weight.

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CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Cited by 24 publications

References 23 publications

Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases

Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases

Impact of metformin on C-reactive protein levels in women with polycystic ovary syndrome: a meta-analysis

Differential Effects of Alternate‐Day Fasting Versus Daily Calorie Restriction on Insulin Resistance

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