Inflammatory bowel disease: no association between allele combinations of the interleukin (IL) 1β and IL‐1 receptor antagonist gene polymorphisms

Ut, Hacker; Bidlingmaier, Christoph; Gomolka, Maria; Keller, E.; Eigler, Andreas; Hartmann, Georgy; Folwaczny, C; Fricke, Harald; Albert, E. D.; Loeschke, K; Endres, Stefan

doi:10.1046/j.1365-2362.1998.00277.x

Cited by 25 publications

(13 citation statements)

References 24 publications

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“…Our results are in accordance with previous studies which were unable to find association between IBD and IL-1β T-31C [24], taqI [19,23] or C-511T [20,21]. The HO-1 A-413T polymorphism has not previously been studied in relation to IBD, whereas no association was found between IBD and HO-1 (GT)N [49].…”

Section: Discussionsupporting

confidence: 91%

“…The variant alleles of two IL-1β promoter polymorphisms, IL-1β T-31C and IL-1β C-511T, have been found to be in almost complete linkage disequilibrium [18], and the haplotypes encompassing the IL-1β T-31C variant conferred higher transcription of IL-1β compared to the wild type haplotype [18]. The role of IL-1β polymorphisms in IBD has been explored in several studies [19-24]. These studies did not find any association with IL-1β , however, the studies were rather small.…”

Section: Introductionmentioning

confidence: 99%

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The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

et al. 2010

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BackgroundCrohns disease (CD) and ulcerative colitis (UC) are characterized by a dysregulated inflammatory response to normal constituents of the intestinal flora in the genetically predisposed host. Heme oxygenase-1 (HO-1/HMOX1) is a powerful anti-inflammatory and anti-oxidant enzyme, whereas the pro-inflammatory interleukin 1β (IL-1β/IL1B) and anti-inflammatory interleukin 10 (IL-10/IL10) are key modulators for the initiation and maintenance of inflammation. We investigated whether single nucleotide polymorphisms (SNPs) in the IL-1β, IL-10, and HO-1 genes, together with smoking, were associated with risk of CD and UC.MethodsAllele frequencies of the IL-1β T-31C (rs1143627), and IL-10 rs3024505, G-1082A (rs1800896), C-819T (rs1800871), and C-592A (rs1800872) and HO-1 A-413T (rs2071746) SNPs were assessed using a case-control design in a Danish cohort of 336 CD and 498 UC patients and 779 healthy controls. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by logistic regression models.ResultsCarriers of rs3024505, a marker polymorphism flanking the IL-10 gene, were at increased risk of CD (OR = 1.40, 95% CI: 1.06-1.85, P = 0.02) and UC (OR = 1.43, 95% CI: 1.12-1.82, P = 0.004) and, furthermore, with risk of a diagnosis of CD and UC at young age (OR = 1.47, 95% CI: 1.10-1.96) and OR = 1.35, 95% CI: 1.04-1.76), respectively). No association was found between the IL-1β, IL-10 G-1082A, C-819T, C-592A, and HO-1 gene polymorphisms and CD or UC. No consistent interactions between smoking status and CD or UC genotypes were demonstrated.ConclusionsThe rs3024505 marker polymorphism flanking the IL-10 gene was significantly associated with risk of UC and CD, whereas no association was found between IL-1β or HO-1 gene polymorphisms and risk of CD and UC in this Danish study, suggesting that IL-10, but not IL-1β or HO-1, has a role in IBD etiology in this population.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

et al. 2010

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“…No association was found between the polymorphisms of IL-6 (2174), TNF-a (2308) or IL-1b TaqI and MM or MGUS patients. The genotype distributions and allele frequencies of the three polymorphisms in controls were similar to other reports (Bioque et al, 1995;Hacker et al, 1998;Fishman et al, 1998;Warzocha et al, 1998). IL-6, TNF-a and IL-1 are essential factors for B-cell growth, differentiation and antibody production.…”

Section: Discussionsupporting

confidence: 89%

Interleukin 6, tumour necrosis factor α, interleukin 1β and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma

Zheng¹,

Huang

Bergenbrant³

et al. 2000

Br J Haematol

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Summary. Proinflammatory cytokines such as interleukin 6 (IL-6), tumour necrosis factor a (TNF-a ) and IL-1b are considered to be involved in the pathogenesis of multiple myeloma (MM). In the present study, we examined a G/C polymorphism at position 2174 in the promoter region of IL-6, a biallelic polymorphism at position 2308 in the promoter region of TNF-a , the TaqI restriction fragment length polymorphism in exon 5 of IL-1b and a variable number of identical tandem repeat polymorphisms in intron 2 of IL-1 receptor antagonist (IL-1Ra) genes. The alleles of these loci are known to influence the level of production of the cytokines and the IL-1Ra. Seventy-three patients with MM, 27 with monoclonal gammopathy of undetermined significance (MGUS) and 129 healthy individuals were included. No difference was found between patients and healthy controls or between MM and MGUS patients in the distributions of genotypes and frequencies of alleles of the IL-6 (2174), TNF-a (2308), IL-1b TaqI and IL-1Ra gene polymorphisms. No associations between the polymorphisms at the loci under study and clinical factors such as age, sex, clinical stage at onset and M-protein type were observed. Our results indicate that the cytokine (IL-6, TNF-a and IL-1b) and IL-Ra gene polymorphisms do not confer susceptibility to the development of MM.

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“…IL-1b ?5887 polymorphism alters IL-1b production following lipopolysaccharide (LPS) stimulation in vitro [36]. However, IL-1b ?5887 genotype was not significantly different between patients and controls [36][37][38][39][40]. IL-1b ?5887 did not have a significant association with anatomic location of the disease [39,40].…”

Section: Discussionmentioning

confidence: 99%

Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease

et al. 2014

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Inflammatory bowel disease: no association between allele combinations of the interleukin (IL) 1β and IL‐1 receptor antagonist gene polymorphisms

Abstract: Thus, we could not confirm the results of a previous study reporting an association between the IL-1ra and IL-1 beta gene polymorphisms in patients with inflammatory bowel disease.

Cited by 25 publications

References 24 publications

The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

Interleukin 6, tumour necrosis factor α, interleukin 1β and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma

Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease

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