Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease

Daryani, Nasser Ebrahimi; Sadr, Maryam; Moossavi, Shirin; Shahkarami, Sepideh; Soltani, Shahin; Farhadi, Elham; Rezaei, Nima

doi:10.1007/s10620-014-3457-z

Cited by 7 publications

(7 citation statements)

References 53 publications

(54 reference statements)

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“…3c ). Many of these cytokines (or their receptors or ligands) have been associated with genetic susceptibility to IBD or have been suggested as drug targets for IBD, including TNF-α ( ref 45 ), IL-6 ( ref 46 ), IL-1RA 47 , CXCL10 ( ref 48 ), and IL-12Rp40 ( ref. 12 ) ( Supplementary Table 24 ).…”

Section: Resultsmentioning

confidence: 99%

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

et al. 2017

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A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data sets to construct predictive models of IBD. We present a predictive model of the immune component of IBD that informs causal relationships among loci previously linked to IBD through genome-wide association studies (GWAS) using functional and regulatory annotations that relate to the cells, tissues, and pathophysiology of IBD. Our model consists of individual networks constructed using molecular data generated from intestinal samples isolated from three populations of patients with IBD at different stages of disease. We performed key driver analysis to identify genes predicted to modulate network regulatory states associated with IBD, prioritizing and prospectively validating 12 of the top key drivers experimentally. This validated key driver set not only introduces new regulators of processes central to IBD but also provides the integrated circuits of genetic, molecular, and clinical traits that can be directly queried to interrogate and refine the regulatory framework defining IBD.

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Section: Resultsmentioning

confidence: 99%

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

et al. 2017

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“…Discordant results regarding the associations between IL1RN genetic variants and IBD have been published. Some studies reported significant associations with CD [ 34 , 35 ] and UC predispositions [ 36 , 37 ], treatment outcome [ 38 ], and age at the onset [ 39 ]; on the contrary, other studies did not find any associations [ 40 – 42 ]. Interestingly, IL-1RN ∗ 2 variant has been associated with reduced levels of IL-1ra protein and IL-1RN mRNA in the colonic mucosa from UC patients [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis

Dobre

Milanesi

Manuc

et al. 2018

Journal of Immunology Research

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Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying nearly two hundred risk loci. Nonetheless, the identified variants rendered only a partial success in providing criteria for the differential diagnosis between ulcerative colitis (UC) and Crohn's disease (CD). Transcript levels from affected intestinal mucosa may serve as tentative biomarkers for improving classification and diagnosis of IBD. The aim of our study was to identify gene expression profiles specific for UC and CD, in endoscopically affected and normal intestinal colonic mucosa from IBD patients. We evaluated a panel of 84 genes related to the IBD-inflammatory pathway on 21 UC and 22 CD paired inflamed and not inflamed mucosa and on age-matched normal mucosa from 21 non-IBD controls. Two genes in UC (CCL11 and MMP10) and two in CD (C4BPB and IL1RN) showed an upregulation trend in both noninflamed and inflamed mucosa compared to controls. Our results suggest that the transcript levels of CCL11, MMP10, C4BPB, and IL1RN are candidate biomarkers that could help in clinical practice for the differential diagnosis between UC and CD and could guide new research on future therapeutic targets.

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“…Such difference scored OR value of 1.76. A previous investigation carried out a similar determination in Iranian IBD patients, and IL1RA mspa 1110 CC genotype was identified to have a positive association with CD, UC and IBD [18]. However, it is too early to reach a final conclusion about the role of IL1RA mspa 11100 SNP in pathogenesis of UC, and the observed association needs a confirmation.…”

Section: Discussionmentioning

confidence: 95%

“…Several SNPs have been described for IL1 genes and among these are IL1A −889 , IL1B −511 , IL1R1 pst1 1970 and IL1RA mspa1 11100 SNPs. Studies in CD and UC patients of different ethnicities have reported different correlations with the two forms of IBD, but some of them suggested that these polymorphisms may play a role in etiopathogenesis of IBD [12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-1 single nucleotide polymorphisms as risk factors for susceptibility of inflammatory bowel disease: an Iraqi Arab population-based study

Ad’hiah

Hessan

Shahab

2019

Alexandria Journal of Medicine

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Objectives: It is aimed to determine the association between four single-nucleotide polymorphisms (SNPs) of IL1 genes (rs1800587: IL1A −889 C/T, rs16944: IL1B −511 T/C, rs2234650: IL1R1 pst1 1970 T/C and rs315952: IL1RA mspa1 11100 T/C) and the two types of IBD (UC and CD) in samples of Iraqi Arab patients. Materials and Methods: Hundred Iraqi patients (66 UC and 34 CD) were genotyped for these SNPs by polymerase chain reaction-specific sequence primer (PCR-SSP) assay. Results: A significant increased frequency of IL1A −889 C allele was observed in total IBD patients compared to controls (72.0 vs. 56.5%; Odds ratio = 1.98; Corrected p = 0.001). For IL1B −511 and IL1R1 pstl 1970 SNPs, the T allele frequency was significantly increased in total patients (62.0 vs. 49.1%; Odds ratio = 1.69; Corrected p = 0.02 and 65.0 vs. 46.7%; Odds ratio = 2.12; Corrected p = 1 × 10 −4 , respectively). Allele and genotype frequencies of IL1RA mspa 11100 SNP showed no significant variation between total patients and controls. A similar profile of was observed in UC patients, but IL1RA mspa 11100 T allele frequency was significantly increased in patients (72.7 vs. 60.2%; Odds ratio = 1.76; Corrected p = 0.05). Among CD patients, IL1A −889 , IL1R1 pstl 1970 and IL1RA mspa 11100 SNP allele frequencies shared their distribution in total IBD patients. For IL1B −511 SNP, allele and genotype frequencies showed no significant difference between CD patients and controls. Conclusion: These data suggests a significant role of IL1 SNPs in etiopathogenesis of IBD in Iraqi Arab population.

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Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease

Abstract: IL-1 SNPs seem to be associated with IBD and could affect the disease severity as well.

Cited by 7 publications

References 53 publications

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis

Interleukin-1 single nucleotide polymorphisms as risk factors for susceptibility of inflammatory bowel disease: an Iraqi Arab population-based study

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