Inflammation in Coronary Artery Ectasia Compared to Atherosclerosis

Yetkın, Ertan; Öztürk, Serkan; Yetkin, Gülay

doi:10.3390/ijms19102971

Cited by 7 publications

(10 citation statements)

References 12 publications

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“…The amount of visceral fat in patients with abdominal obesity is significantly elevated, which significantly increases insulin resistance and the levels of chronic inflammatory factors, thereby causing increased morbidity of vascular diseases. 17 In the present study, there was a more substantial increase in WHR than in BMI in the T2DM þ LEAD group, demonstrating that abdominal obesity, represented by WHR, plays a greater role in DM-associated LEAD. Furthermore, SMI was closely correlated with LEAD.…”

Section: Discussionsupporting

confidence: 51%

Correlation between lower extremity arterial disease and skeletal muscle mass in patients with type 2 diabetes mellitus

et al. 2020

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Objectives To evaluate skeletal muscle mass in patients with both type 2 diabetes mellitus (T2DM) and concomitant lower extremity arterial disease (LEAD) and determine the contribution of skeletal muscle mass to macrovascular diseases. Methods In total, 112 patients with T2DM were divided into the T2DM and T2DM + LEAD groups. Hepatic function, renal function, uric acid, blood glucose, and glycated hemoglobin (HbA1C) were measured. Dual-energy X-ray absorptiometry was used to measure visceral fat area and skeletal muscle mass index (SMI). Results Waist-to-hip ratio, uric acid, and body fat percentage were significantly higher in the T2DM+LEAD group than in the T2DM group; SMI was significantly lower in the T2DM+LEAD group than in the T2DM group. There were no significant differences in albumin, creatinine, fasting blood glucose, HbA1C, or blood lipids. Uric acid, SMI, and body fat percentage were significantly positively correlated with T2DM and concomitant LEAD. Logistic regression analyses suggested that SMI is an independent risk factor for LEAD in T2DM (odds ratio = 1.517; 95% confidence interval: 1.082–2.126). Conclusions Skeletal muscle mass is lower in patients with T2DM and concomitant LEAD than in patients with T2DM who do not exhibit LEAD. SMI is an important risk factor for LEAD.

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Section: Discussionsupporting

confidence: 51%

Correlation between lower extremity arterial disease and skeletal muscle mass in patients with type 2 diabetes mellitus

et al. 2020

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“…As was explained previously, the inflammatory process in CAE is beyond a localised atherosclerotic process. Additionally, high serum levels of several inflammatory biomarkers -including interferon-gamma, tumour necrosis factor-α, IL-1β, IL-6, and IL-8 -in CAE compared with those in CAD may be another reason for these different results 22. There might be some other probable hypothetical mechanisms for our findings.…”

mentioning

confidence: 73%

“…Thus, isolated CAE should be investigated independently of CAD to obtain further information about its underlying mechanism. 20,22 Liver transaminases, including AST and ALT, are widely used and routinely measured markers in a clinical setting. Previous studies have suggested that increased serum levels of ALT and AST are independently associated with atherosclerosis and cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Ratio of Serum Aspartate to Alanine Aminotransferase as a Marker of Isolated Coronary Artery Ectasia and its Severity

Soltani¹,

Jafari²,

Ashraf³

et al. 2020

Heart International

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“…In this regard, the enlargement of the carotid artery can be viewed as an indicator of unbalanced carotid arterial tensile stress of the ventricular-arterial system. This may be caused by synergistic aging, a chronic hemodynamic load, and proteolytic/elastolytic activity from an up-regulated pro-inflammatory status, all of which are also potential markers of heightened cardiovascular risk [39][40][41] as part of "dilating arterial disease" syndrome [42,43].…”

Section: Discussionmentioning

confidence: 99%

Circulating Monocyte Count as a Surrogate Marker for Ventricular-Arterial Remodeling and Incident Heart Failure with Preserved Ejection Fraction

et al. 2020

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Among 2085 asymptomatic subjects (age: 51.0 ± 10.7 years, 41.3% female) with data available on common carotid artery diameter (CCAD) and circulating total white blood cell (WBC) counts, higher circulating leukocytes positively correlated with higher high sensitivity C-reactive protein (hs-CRP). Higher WBC/segmented cells and monocyte counts were independently associated with greater relative wall thicknesses and larger CCADs, which in general were more pronounced in men and obese subjects (body mass index ≥ 25 kg/m2) (all P interaction: < 0.05). Using multivariate adjusting models, only the monocyte count independently predicted the left ventricular mass index (LVMi) (ß-Coef: 0.06, p = 0.01). Higher circulating WBC, segmented, and monocyte counts and a greater CCAD were all independently associated with a higher risk of heart failure (HF)/all-cause death during a median of 12.1 years of follow-up in fully adjusted models, with individuals manifesting both higher CCADs and monocyte counts incurring the highest risk of HF/death (adjusted hazard ratio: 2.81, 95% CI: 1.57. −5.03, p < 0.001; P interaction, 0.035; lower CCAD/lower monocyte as reference). We conclude that a higher monocyte count is associated with cardiac remodeling and carotid artery dilation. Both an elevated monocyte count and a larger CCAD may indicate a specific phenotype that confers the highest risk of HF, which likely signifies the role of circulating monocytes in the pathophysiology of heart failure with preserved ejection fraction (HFpEF).

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Inflammation in Coronary Artery Ectasia Compared to Atherosclerosis

Abstract: We have read with great enthusiasm the article recently published by Boles et al. [...]

Cited by 7 publications

References 12 publications

Correlation between lower extremity arterial disease and skeletal muscle mass in patients with type 2 diabetes mellitus

Correlation between lower extremity arterial disease and skeletal muscle mass in patients with type 2 diabetes mellitus

Ratio of Serum Aspartate to Alanine Aminotransferase as a Marker of Isolated Coronary Artery Ectasia and its Severity

Circulating Monocyte Count as a Surrogate Marker for Ventricular-Arterial Remodeling and Incident Heart Failure with Preserved Ejection Fraction

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