Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease

Xu, Qiuyun; Zhou, Xiaorong; Strober, Warren; Mao, Liming

doi:10.3390/molecules26061725

Cited by 18 publications

(11 citation statements)

References 112 publications

(118 reference statements)

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“…(2020) found elevated levels of viral diversity in some infected individuals, suggesting a risk of rapid evolution. Although no evidence of intra - host mutation transmission has been found, this risk should not be ignored ( Emrani et al., 2021 ; Xu et al., 2021 ; Zhang et al., 2021a ). So far, SARS-COV-2 has been identified as Alpha, Beta, Gamma, Zeta, Delta, Lambda, Omicron and other variants, two of which need to be noted.…”

Section: The Evolution and Variation Of Sars - ...mentioning

confidence: 99%

SARS-CoV-2: The Monster Causes COVID-19

Song

et al. 2022

Front. Cell. Infect. Microbiol.

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Coronaviruses are viruses whose particles look like crowns. SARS-CoV-2 is the seventh member of the human coronavirus family to cause COVID-19 which is regarded as a once-in-a-century pandemic worldwide. It holds has the characteristics of a pandemic, which has broy -55ught many serious negative impacts to human beings. It may take time for humans to fight the pandemic. In addition to humans, SARS-CoV-2 also infects animals such as cats. This review introduces the origins, structures, pathogenic mechanisms, characteristics of transmission, detection and diagnosis, evolution and variation of SARS-CoV-2. We summarized the clinical characteristics, the strategies for treatment and prevention of COVID-19, and analyzed the problems and challenges we face.

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Section: The Evolution and Variation Of Sars - ...mentioning

confidence: 99%

SARS-CoV-2: The Monster Causes COVID-19

Song

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Inflammasome sensor proteins are a class of PRRs that have been identified as playing an important role in intestinal immunity ( Xu et al, 2021 ). Canonical inflammasomes are multiprotein complexes formed in response to PAMPs and DAMPs which consist of a sensor, an adaptor [apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)], and pro-caspase-1.…”

Section: Introductionmentioning

confidence: 99%

“…GSDMD pores facilitate the release of IL-1β and IL-18, while cell lysis further promotes inflammatory signalling through the release of DAMPs ( Shi et al, 2015a ; Broz and Dixit, 2016 ; Liu et al, 2016 ; Van Opdenbosch and Lamkanfi, 2019 ) ( Figure 1 ). Multiple sensor proteins capable of forming canonical inflammasomes have been identified including NOD-like receptor (NLR) Family Pyrin Domain Containing 1 (NLRP1), NLRP3, NLRP6, NLR Family CARD Domain Containing 4 (NLRC4), Pyrin, and absent in melanoma 2 (AIM2) ( Broz and Dixit, 2016 ; Xu et al, 2021 ). Deficiency in NLRC4, NLRP6, Pyrin and AIM2 is reported to aggravate the symptoms of dextran sulphate sodium (DSS)-induced colitis, a common mouse model used to emulate acute colitis ( Chen et al, 2011 ; Carvalho et al, 2012 ; Ratsimandresy et al, 2017 ; Sharma et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease

Smith

Creagh

2022

Front. Pharmacol.

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Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the gastrointestinal tract, associated with high levels of inflammatory cytokine production. Human caspases-4 and -5, and their murine ortholog caspase-11, are essential components of the innate immune pathway, capable of sensing and responding to intracellular lipopolysaccharide (LPS), a component of Gram-negative bacteria. Following their activation by LPS, these caspases initiate potent inflammation by causing pyroptosis, a lytic form of cell death. While this pathway is essential for host defence against bacterial infection, it is also negatively associated with inflammatory pathologies. Caspases-4/-5/-11 display increased intestinal expression during IBD and have been implicated in chronic IBD inflammation. This review discusses the current literature in this area, identifying links between inflammatory caspase activity and IBD in both human and murine models. Differences in the expression and functions of caspases-4, -5 and -11 are discussed, in addition to mechanisms of their activation, function and regulation, and how these mechanisms may contribute to the pathogenesis of IBD.

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“… 116 Signal integration and propagation via the inflammasome provides another opportunity to impact multiple inflammatory mediators. 144 , 145 …”

Section: Introductionmentioning

confidence: 99%

Research-Based Product Innovation to Address Critical Unmet Needs of Patients with Inflammatory Bowel Diseases

Honig

Larkin

Heller

et al. 2021

Inflammatory Bowel Diseases

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Despite progress in recent decades, patients with inflammatory bowel diseases face many critical unmet needs, demonstrating the limitations of available treatment options. Addressing these unmet needs will require interventions targeting multiple aspects of inflammatory bowel disease pathology, including disease drivers that are not targeted by available therapies. The vast majority of late-stage investigational therapies also focus primarily on a narrow range of fundamental mechanisms. Thus, there is a pressing need to advance to clinical stage differentiated investigational therapies directly targeting a broader range of key mechanistic drivers of inflammatory bowel diseases. In addition, innovations are critically needed to enable treatments to be tailored to the specific underlying abnormal biological pathways of patients; interventions with improved safety profiles; biomarkers to develop prognostic, predictive, and monitoring tests; novel devices for nonpharmacological approaches such as minimally invasive monitoring; and digital health technologies. To address these needs, the Crohn’s & Colitis Foundation launched IBD Ventures, a venture philanthropy–funding mechanism, and IBD Innovate®, an innovative, product-focused scientific conference. This special IBD Innovate® supplement is a collection of articles reflecting the diverse and exciting research and development that is currently ongoing in the inflammatory bowel disease field to deliver innovative and differentiated products addressing critical unmet needs of patients. Here, we highlight the pipeline of new product opportunities currently advancing at the preclinical and early clinical development stages. We categorize and describe novel and differentiated potential product opportunities based on their potential to address the following critical unmet patient needs: (1) biomarkers for prognosis of disease course and prediction/monitoring of treatment response; (2) restoration of eubiosis; (3) restoration of barrier function and mucosal healing; (4) more effective and safer anti-inflammatories; (5) neuromodulatory and behavioral therapies; (6) management of disease complications; and (7) targeted drug delivery.

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Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease

Cited by 18 publications

References 112 publications

SARS-CoV-2: The Monster Causes COVID-19

SARS-CoV-2: The Monster Causes COVID-19

Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease

Research-Based Product Innovation to Address Critical Unmet Needs of Patients with Inflammatory Bowel Diseases

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