Infertility treatment outcome in sub groups of obese population

Effects of female increased body mass index on in vitro fertilization cycles outcome

“…This remained true after exclusion of women with PCOS, suggesting that female overweight and obesity have an impact on ovarian response to stimulation independently of PCOS status. Most studies conducted in obese women undergoing IVF cycles reported the same observation [4,[7][8][9][10]14,16,19,20,25], raising several hypotheses. First, this increased dose requirement of gonadotrophin may be related to altered pharmocodynamics characteristics of drugs administered subcutaneously in obese women having increased subcutaneous fat thickness.…”

“…Concerning ovarian stimulation, some authors have shown increased duration of stimulation, higher total dose of gonadotrophin administered [7][8][9][10][11][12][13][14][15], lower ovarian response to ovarian stimulation, with reduced oocytes retrieval [8,11,12,14,15], poorer embryo quality [9,11] and lower fertilization rates in obese women undergoing in vitro fertilization (IVF) compared with normal weight infertile women [10,13]. However, other authors found no differences in IVF outcome according to female body mass index (BMI) [7,16,17].…”

Obesity adversely impacts the number and maturity of oocytes in conventional IVF not in minimal stimulation IVF

“…25 kg/m 2 [43] as well as in those with BMI 436 kg/m 2 [44] compared with normal weight controls. Additionally, several studies have demonstrated decreased odds of clinical pregnancy rates in patients with elevated BMI [41,45,46].…”

The effect of body mass index on the outcomes of first assisted reproductive technology cycles

“…Several studies have demonstrated decreased odds of CP in patients with higher BMI (9,10,16,31). However, many more studies have failed to identify a statistically significant difference (7,8,20,(25)(26)(27)(28)(29)(30), including two meta-analyses of 21 and 13 studies that demonstrated a lower chance of CP with obesity (32,33).…”

“…Studies suggest that obese patients require higher stimulation doses of gonadotropins and suffer potentially lower clinical pregnancy (CP) rates compared with patients with normal BMI (7)(8)(9)(10). Recent systematic reviews and meta-analyses demonstrated that obese patients using assisted reproductive technologies (ART) require higher doses of gonadotropins, yield a lower number of oocytes per cycle, have higher rates of spontaneous abortions, and exhibit lower CP rates (11,12).…”