Effects of female increased body mass index on in vitro fertilization cycles outcome

Caillon, Hélène; Fréour, Thomas; Bach-Ngohou, Kalyane; Colombel, A.; Denis, Marc G.; Barrière, P.; Masson, Damien

doi:10.1016/j.orcp.2015.02.009

Cited by 47 publications

(33 citation statements)

References 38 publications

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“…Data on the potential effects of elevated BMI on fertility treatment outcomes are conflicting. Multiple studies have reported no significant adverse effects of elevated BMI on IVF outcomes [28][29][30][31][32]; however, others have found associations between elevated BMI and higher gonadotropin requirements, fewer oocytes collected, higher cancellation rates, reduced pregnancy and live birth rates, and higher miscarriage rates [33][34][35][36][37][38][39][40][41][42][43][44][45]. Whether obesity has a negative effect on implantation and postimplantation events and on oocyte and embryo quality remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer

Boynukalın¹,

Gültomruk²,

Cavkaytar³

et al. 2020

PLoS ONE

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Background To assess the predictive value of patient characteristics, controlled ovarian stimulation and embryological parameters on the live birth outcome of single euploid frozen-warmed blastocyst transfer (FBT). Methods This was a retrospective cohort study including 707 single FBTs after preimplantation genetic testing for aneuploidy (PGT-A) that were performed from October 1, 2015, to January 1, 2018. The effects of patient-, cycle-and embryology-related parameters on the live birth outcome after FBT were assessed.

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Section: Discussionmentioning

confidence: 99%

Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer

Boynukalın¹,

Gültomruk²,

Cavkaytar³

et al. 2020

PLoS ONE

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“…Unfortunately, in some studies (14)(15)(16), the obese group was included in the overweight group for analysis rather than the subdivision analysis. Though the mechanism of the negative effect of BMI on IVF outcome is unclear, the relationship may have a threshold effect on the CLBR by accumulative BMI.…”

Section: Discussionmentioning

confidence: 99%

Cumulative Live Birth Rates According to Maternal Body Mass Index After First Ovarian Stimulation for in vitro Fertilization: A Single Center Analysis of 14,782 Patients

et al. 2020

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Objective: To investigate the cumulative live birth rates (CLBR) according to body mass index (BMI) in women undergoing their first in vitro fertilization (IVF). Design: Retrospective cohort analysis. Setting: An IVF clinic in a public hospital. Patients: This is a retrospective study of 14,782 patients undergoing their first fresh IVF cycles and subsequent frozen embryo transfers in our clinic from January 2014 to January 2017. The follow-up for CLBR continued until January 2019. Patients with a BMI <18.5 kg/m 2 were considered to be underweight and those with a BMI > 24 kg/m 2 were considered to be overweight. Patients with a BMI ≥ 28 kg/m 2 were considered to be obese. Intervention(s): None. Primary Outcome Measure: The primary outcome was cumulative live birth rate (CLBR). Result(s): This study illustrated the "inverted U shape" associations between body weight and IVF outcome (CLBR). The turning points in threshold analysis, as found by an automatic search, were BMIs of 18.5 and 30.4 kg/m 2. The main finding of this retrospective data analysis is that the CLBR increased in underweight women, plateaued for normal weight and overweight women with a BMI between 18.5 and 30.4 kg/m 2 , and decreased in obese women. Conclusion(s): The data suggested an "inverted U shape" association between BMI and CLBR. The CLBR increases in underweight women, plateaus in normal weight and overweight women, and then decreases in obese women.

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“…As maternal obesity is associated with changes to the uterine environment including increased inflammatory markers (71), and changes to uterine fluid composition (11,91), it is likely that this perturbed environment is acting as a "second hit" further perturbing fetal growth. Interestingly, we also saw a worsened early embryo phenotype from in vitro culture of embryos produced from paternal HFD, indicating that the in vitro culture itself and/or the superovulation protocol was interacting with the paternal HFD.…”

Section: Combined Paternal and Maternal Obesity Alters Fetal And Placmentioning

confidence: 99%

When two obese parents are worse than one! Impacts on embryo and fetal development

McPherson

Bell

Zander-Fox

et al. 2015

American Journal of Physiology-Endocrinology and Metabolism

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McPherson NO, Bell VG, Zander-Fox DL, Fullston T, Wu LL, Robker RL, Lane M. When two obese parents are worse than one! Impacts on embryo and fetal development. Am J Physiol Endocrinol Metab 309: E568 -E581, 2015. First published July 21, 2015; doi:10.1152/ajpendo.00230.2015.-The prevalence of overweight and obesity in reproductive-age adults is increasing worldwide. While the effects of either paternal or maternal obesity on gamete health and subsequent fertility and pregnancy have been reported independently, the combination of having both parents overweight/ obese on fecundity and offspring health has received minimal attention. Using a 2 ϫ 2 study design in rodents we established the relative contributions of paternal and maternal obesity on fetal and embryo development and whether combined paternal and maternal obesity had an additive effect. Here, we show that parental obesity reduces fetal and placental weights without altering pregnancy establishment and is not dependent on an in utero exposure to a high-fat diet. Interestingly combined parental obesity seemed to accumulate both the negative influences of paternal and maternal obesity had alone on embryo and fetal health rather than an amplification, manifested as reduced embryo developmental competency, reduced blastocyst cell numbers, impaired mitochondrial function, and alterations to active and repressive embryonic chromatin marks, resulting in aberrant placental gene expression and reduced fetal liver mtDNA copy numbers. Further understanding both the maternal cytoplasmic and paternal genetic interactions during this early developmental time frame will be vital for understanding how developmental programming is regulated and for the proposition of interventions to mitigate their effects. blastocyst; oocyte; sperm; embryo; fertility; infertility; obesity THE PREVALENCE OF OVERWEIGHT and obesity in reproductive-age adults is increasing worldwide (62). For example, in America it is estimated that 70.9% of males and 61.9% of women are classified as overweight/obese (62). The comorbidities associated with obesity have been well defined; however, until recently the impact on pregnancy and fetal development has been less recognized. Although the effects of either paternal or maternal obesity on gamete health and subsequent fertility and pregnancy have been reported independently, the combination of having both parents overweight/obese on fecundity and offspring health has received minimal attention. This information is essential, as the percentage of couples of reproductive age with both partners overweight/ obese is increasing and is the predominant situation in many countries (62).To date, there have only been three studies that have assessed the combined effects of maternal and paternal obesity on pregnancy and fetal health, two in human-assisted reproductive technology (ART) cohorts and one using a rodent high-fat diet model (41,67,76). These studies found no effect of maternal and paternal obesity on pregnancy establishment (41, 67, 76); however, when ...

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Effects of female increased body mass index on in vitro fertilization cycles outcome

Cited by 47 publications

References 38 publications

Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer

Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer

Cumulative Live Birth Rates According to Maternal Body Mass Index After First Ovarian Stimulation for in vitro Fertilization: A Single Center Analysis of 14,782 Patients

When two obese parents are worse than one! Impacts on embryo and fetal development

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