The effect of body mass index on the outcomes of first assisted reproductive technology cycles

Moragianni, Vasiliki A.; Jones, Stephanie-Marie L.; Ryley, David A.

doi:10.1016/j.fertnstert.2012.04.004

Cited by 153 publications

(102 citation statements)

References 34 publications

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“…In a recent systematic review and meta-analysis [67] of 33 studies (47,967 Similarly, an analysis of 4609 women with first autologous fresh IVF or IVFeintracytoplasmic sperm injection (ICSI) cycles revealed that women with BMI 30.0 kg/m 2 had significantly decreased odds of implantation, CP and LB. This study concluded that obese women had up to 65% lower odds of having an LB following their first assisted reproductive technology (ART) cycle, compared with women of BMI <30 kg/m 2 [68].…”

Section: Assisted Reproductionmentioning

confidence: 99%

Medical and surgical interventions to improve outcomes in obese women planning for pregnancy

Sharma

Bahadursingh

Ramsewak

et al. 2015

Best Practice & Research Clinical Obstetrics & Gynaecol

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Section: Assisted Reproductionmentioning

confidence: 99%

Medical and surgical interventions to improve outcomes in obese women planning for pregnancy

Sharma

Bahadursingh

Ramsewak

et al. 2015

Best Practice & Research Clinical Obstetrics & Gynaecol

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“…Moreover, obese women undergoing controlled ovarian hyperstimulation (COH) with oocyte retrieval for in vitro fertilization (IVF), in which spontaneous ovulation is not a factor, also have worse outcomes than normal-weight women. They have poorer responses to assisted reproduction treatment with increased amounts of gonadotropin used, increased cancellation rates, decreased number of oocytes retrieved, decreased implantation, clinical pregnancy and live birth rates, and increased miscarriage rates [9][10][11][12][13]. Although the effect of obesity on fertility is likely multi-faceted, it has been demonstrated that obese patients exhibit an altered ovarian follicular environment in multiple systems, including steroidogenic action, metabolism, and inflammation, which may contribute to these poorer outcomes [14].…”

Section: Introductionmentioning

confidence: 99%

Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women

Moy

Jindal

Lieman

et al. 2015

J Assist Reprod Genet

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Objective Previous studies regarding the effect of obesity on serum anti-müllerian hormone (AMH) levels have been conflicting. Our aim was to determine the effect of obesity on serum AMH levels among women from different racial backgrounds. Methods The medical records of 350 women (159 Caucasian, 99 African-American, 58 Hispanic, 34 Asian with ages 16-46) evaluated for infertility at an academic-affiliated center and who had AMH levels measured as part of their evaluation were reviewed. Age, AMH, body mass index (BMI), selfreported race, etiology of infertility, smoking history, maximum serum early follicular follicle-stimulating hormone (FSH) levels, antral follicle count (AFC), and history of ovarian surgery, chemotherapy, or radiotherapy were recorded. Results Age correlated negatively with AMH and antral follicle count across all races (p<0.05). After adjusting for age, polycystic ovary syndrome diagnosis, and smoking, elevated BMI had a negative correlation with AMH in Caucasian women (β=0.17, p=0.01) but not in African-American, Hispanic, or Asian women. Conclusion Elevated BMI correlates negatively with AMH in Caucasian women but not in African-American, Hispanic, or Asian women. Additional studies are needed to elucidate further the effect of race on the interaction between obesity and ovarian reserve.

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“…Therefore a negative effect of abnormal BMI on clinical outcome cannot be excluded. Despite the differences between IVM and IVF cycles, our results should also be considered in the context of previous studies investigating effect of BMI on IVF outcomes, as both treatments also share common steps to successful implantation and delivery [3][4][5][6][7]20,21].…”

Section: Discussionmentioning

confidence: 80%

Effect of Body Mass Index on In Vitro Maturation Treatment Outcomes in Women without Polycystic Ovarian Syndrome

Ata¹

2013

J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol

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Purpose: Previous studies have suggested that obesity can affect the oocyte yield, embryo quality and pregnancy rates following IVF. In vitro maturation differs from IVF in several ways including lack of controlled ovarian stimulation, oocyte retrieval when majority are expected to be still immature, and possibly different endometrial environment due to short secretory phase and the lack of exposure to supraphysiologic estrogen levels. Therefore female obesity can affect IVM and IVF cycles differentially. This study aims to assess the effect of female obesity on IVM outcomes in women without polycystic ovarian syndrome. Methods:Retrospective chart review of 125 women who underwent an IVM cycle during a 5 year period. Women were divided to four categories based on Body Mass Index (BMI) according to the World Health Organization classification. Procedural and clinical outcomes were compared across different BMI categories. Independent effect of BMI on the odds of achieving a live birth was assessed using a multivariate logistic regression model. Results:The numbers of cumulus corona complexes, in vivo matured and immature oocytes collected, metaphase two oocytes available for fertilization, good quality embryos available for transfer and embryos transferred were not statistically significantly different across BMI categories. Likewise, in vitro maturation rate of immature oocytes, fertilization rate, embryo implantation, clinical pregnancy and live birth rates were similar across the groups. BMI category did not have an independent effect after adjusting for possible confounders in the regression model. Conclusions:BMI does not seem to affect IVM outcomes.

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The effect of body mass index on the outcomes of first assisted reproductive technology cycles

Cited by 153 publications

References 34 publications

Medical and surgical interventions to improve outcomes in obese women planning for pregnancy

Medical and surgical interventions to improve outcomes in obese women planning for pregnancy

Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women

Effect of Body Mass Index on In Vitro Maturation Treatment Outcomes in Women without Polycystic Ovarian Syndrome

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