Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women

Moy, V.; Jindal, Sangita; Lieman, Harry; Büyük, Erkan

doi:10.1007/s10815-015-0538-7

Cited by 70 publications

(60 citation statements)

References 38 publications

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“…Similar to our findings, many studies have not found an association between current BMI and serum AMH levels (21–26); however, some studies have reported lower AMH levels among obese women (17–20). In light of these conflicting results, some researchers have suggested that inverse associations between BMI and AMH in some studies may reflect residual confounding by age (which is inversely related to AMH) (22) or the phenomenon of serum hormone dilution due to increased blood volume among larger women (21).…”

Section: Discussionsupporting

confidence: 91%

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Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women

Bertrand

Baer

Orav

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Emerging evidence suggests positive associations between serum antimüllerian hormone (AMH), a marker of ovarian function, and breast cancer risk. Body size at young ages may influence AMH levels, but few studies have examined this. Also, no studies have examined the relation of AMH levels with breast density, a strong predictor of breast cancer risk. Methods We examined associations of early life body fatness, AMH concentrations, and breast density among 172 women in the Dietary Intervention Study in Children (DISC). Height and weight were measured at baseline (ages 8–10) and throughout adolescence. Serum AMH concentrations and breast density were assessed at ages 25–29 at the DISC06 Follow-Up visit. We used linear mixed effects models to quantify associations of AMH (dependent variable) with quartiles of age-specific youth body mass index (BMI) Z-scores (independent variable). We assessed cross-sectional associations of breast density (dependent variable) with AMH concentration (independent variable). Results Neither early life BMI nor current adult BMI was associated with AMH concentrations. There were no associations between AMH and percent or absolute dense breast volume. In contrast, women with higher AMH concentrations had significantly lower absolute non-dense breast volume (p-trend <0.01). Conclusions We found no evidence that current or early life BMI influences AMH concentrations in later life. Women with higher concentrations of AMH had similar percent and absolute dense breast volume, but lower non-dense volume. Impact These results suggest that AMH may be associated with lower absolute non-dense breast volume; however, future prospective studies are needed to establish temporality.

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Section: Discussionsupporting

confidence: 91%

“…Inverse associations of AMH with adiposity have been reported in some studies (17–20), while others showed no clear associations (17, 18, 20–28). Further, few studies have examined the possible role of adiposity earlier in life.…”

Section: Introductionmentioning

confidence: 90%

Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women

Bertrand

Baer

Orav

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…We have previously shown in humans that obesity has a negative impact on ovarian function, in particular on genes important in follicular development and ovarian reserve [27,[43][44][45][46][47][48]. In the current study, we did not find an association between BMI and kisspeptin expression in human GCs and we did not find that diet-induced obesity affected ovarian kiss1/kiss1r expression in mice.…”

Section: Discussioncontrasting

confidence: 80%

Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1

Merhi

Thornton

Bonney

et al. 2016

J Assist Reprod Genet

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Purpose The objective of this study was to test the hypothesis that ovarian kisspeptin (kiss1) and its receptor (kiss1r) expression are affected by age, obesity, and the age-and obesityrelated chemokine monocyte chemoattractant protein-1 (MCP-1). Methods Ovaries from reproductive-aged and older C57BL/ 6J mice fed normal chow (NC) or high-fat (HF) diet, ovaries from age-matched young MCP-1 knockout and young control mice on NC, and finally, cumulus and mural granulosa cells (GCs) from women who underwent in vitro fertilization (IVF) were collected. Kiss1, kiss1r, anti-Mullerian hormone (AMH), and AMH receptor (AMHR-II) messenger RNA (mRNA) expression levels were quantified using real-time polymerase chain reaction (RT-PCR).Results In mouse ovaries, kiss1 and kiss1r mRNA levels were significantly higher in old compared to reproductive-aged mice, and diet-induced obesity did not alter kiss1 or kiss1r mRNA levels. Compared to young control mice, young MCP-1 knockout mice had significantly lower ovarian kiss1 mRNA but significantly higher AMH and AMHR-II mRNA levels. In human cumulus GCs, kiss1r mRNA levels were positively correlated with age but not with BMI. There was no expression of kiss1 mRNA in either cumulus or mural GCs. Conclusion These data suggest a possible age-related physiologic role for the kisspeptinergic system in ovarian physiology. Additionally, the inflammatory MCP-1 may be associated with kiss1 and AMH genes, which are important in ovulation and folliculogenesis, respectively.

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“…On one hand, higher BMI has not been shown to be associated with earlier ovarian aging, as demonstrated by earlier menopause [20]. On the other hand, lower AMH, an indirect measure of poor ovarian reserve, is seen in virtually all reports on the subject [24][25][26][27]. In our study there was a trend towards lower AMH and growing follicle numbers in obese animals exposed to HFD for 32 wk, yet it did not reach statistical significance.…”

Section: Skaznik-wikiel Et Alcontrasting

confidence: 81%

High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice

Skaznik-Wikiel

Swindle

Allshouse

et al. 2016

Obstetrical &Amp; Gynecological Survey

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Excess calorie consumption, particularly of a diet high in fat, is a risk factor for both obesity and reproductive disorders. Animal model studies indicate that elevated dietary fat can influence some reproductive functions independent of obesity. In the current study we sought to determine whether a high-fat diet (HFD) impacts ovarian function, long-term fertility, and local and systemic markers of inflammation independent of obesity. Five-week-old mice were fed either low-fat diet (control group-LF-Ln) or HFD for 10 wk and were divided based on body weight into high-fat obese (HF-Ob: .25 g) and high-fat lean (HFLn: ,22 g). Ovaries were collected to assess ovarian follicles and to determine the degree of local inflammation. Serum proinflammatory cytokines were also measured. A group of animals was followed for breeding trials for 5 mo while being exposed to LFD or HFD. We found that both 10-wk and 32-wk exposure to HFD resulted in depleted primordial follicles regardless of obesity phenotype. Macrophage counts revealed increased tissue inflammation in the ovary independent of obesity. In addition, serum proinflammatory cytokines were increased in HF-Ln and HF-Ob in comparison to LF-Ln mice. Moreover, HFD had a sustained effect on litter production rate and number of pups per litter regardless of obese phenotype. This study describes for the first time that exposure to HFD causes significant reduction in primordial follicles, compromised fertility, produced higher proinflammatory cytokine levels, and increased ovarian macrophage infiltration, independent of obesity. The negative effects of HFD on primordial follicles may be mediated by increased tissue inflammation.fertility, high-fat diet, inflammation, ovary

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Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women

Cited by 70 publications

References 38 publications

Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women

Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women

Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1

High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice

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