Infective endocarditis following heart transplantation: A systematic review

Jordan, Andrew M.; Tatum, Robert; Ahmad, Danial; Patel, Sinal; Maynes, Elizabeth J.; Weber, Matthew P.; Moss, Sean; Royer, Tricia; Tchantchaleishvili, Vakhtang; Massey, H. Todd; Rame, J. Eduardo; Zurlo, John; Aburjania, Nana

doi:10.1016/j.trre.2021.100672

Cited by 9 publications

(13 citation statements)

References 27 publications

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“…T he risk of infection such as endocarditis remains considerable after heart transplantation 6,9,13,14 Although it is well known that solid organ transplants have increased perioperative complications post TJA, a majority of these studies report outcomes in kidney and liver transplant patient. To the best of our knowledge, this is the first case report of a patient presenting with acute bilateral hematogenous periprosthetic knee joint infections from endocarditis of a heart transplant.…”

Section: Discussionmentioning

confidence: 99%

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Management of Bilateral Synchronous Knee Prosthetic Joint Infection in a Patient with Infected Heart Transplant

Jeong

Yang

Rubin

et al. 2023

JBJS Case Connector

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Case: A 74-year-old man presented with septic shock with infection of his heart transplant and bilateral prosthetic knee joints simultaneously. He underwent bilateral knee resection arthroplasties with placement of articulating spacers. At 3-year follow-up, the patient was alive and ambulating independently. Conclusion: This case represents the first report of bilateral hematogenous prosthetic knee infections associated with concomitant enterococcal endocarditis of a heart transplant treated successfully and definitively with radical debridement and placement of articulating spacer with regular implants.

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Section: Discussionmentioning

confidence: 99%

“…Most complications occur during the first month after surgery and are difficult to manage. One such life-threatening complication is infective endocarditis, a rare (1.5%) but potentially fatal complication after heart transplant 6,7 .…”

mentioning

confidence: 99%

Management of Bilateral Synchronous Knee Prosthetic Joint Infection in a Patient with Infected Heart Transplant

Jeong

Yang

Rubin

et al. 2023

JBJS Case Connector

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“…However, the high associated mortality deserve attention. Jordan et al identified 57 heart transplant recipients with infective endocarditis [26], 63% of bacterial origin. Only 12% were device-related and one-third required surgery, including re-transplantation in two cases.…”

Section: Key Pointsmentioning

confidence: 99%

Bacterial infections in solid organ transplant recipients

Courjon,

Neofytos,

van Delden

2024

Current Opinion in Organ Transplantation

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Purpose of review Bacteria are the leading cause of infections in solid organ transplant (SOT) recipients, significantly impacting patient outcome. Recently detailed and comprehensive epidemiological data have been published. Recent finding This literature review aims to provide an overview of bacterial infections affecting different types of SOT recipients, emphasizing underlying risk factors and pathophysiological mechanisms. Summary Lung transplantation connects two microbiotas: one derived from the donor's lower respiratory tract with one from the recipient's upper respiratory tract. Similarly, liver transplantation involves a connection to the digestive tract and its microbiota through the bile ducts. For heart transplant recipients, specific factors are related to the management strategies for end-stage heart failure based with different circulatory support tools. Kidney and kidney–pancreas transplant recipients commonly experience asymptomatic bacteriuria, but recent studies have suggested the absence of benefice of routine treatment. Bloodstream infections (BSI) are frequent and affect all SOT recipients. Nonorgan-related risk factors as age, comorbidity index score, and leukopenia contribute to BSI development. Bacterial opportunistic infections have become rare in the presence of efficient prophylaxis. Understanding the epidemiology, risk factors, and pathophysiology of bacterial infections in SOT recipients is crucial for effective management and improved patient outcomes.

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“…Staphylococcus is among the most common causes of endovascular infections, including infective endocarditis (IE), which may occur in the setting of a bloodstream infection [ 12 – 14 ]. In an experimental aortic valve MRSA IE rabbit model, transthoracic echocardiography was utilized to evaluate the in vivo effect of exebacase on vegetation progression when combined with daptomycin (versus daptomycin alone) [ 8 ].…”

Section: Clinical Relevancementioning

confidence: 99%

Exebacase: A Novel Approach to the Treatment of Staphylococcal Infections

McCarthy

2022

Drugs R D

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Lysins are bacteriophage-derived enzymes that degrade essential components of bacteria. Exebacase (Lysin CF-301) is an attractive antimicrobial agent because it demonstrates rapid bacteriolytic activity against staphylococcal species, including Staphylococcus aureus, has a low resistance profile, eradicates biofilms, and acts synergistically with other antibiotics. Combinations including exebacase and standard of care antibiotics represent an alternative to antibiotic monotherapies currently used to treat invasive staphylococcal infections. This manuscript reviews what is known about exebacase and explores how this novel agent may be used in the future to treat human bacterial pathogens.

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Infective endocarditis following heart transplantation: A systematic review

Cited by 9 publications

References 27 publications

Management of Bilateral Synchronous Knee Prosthetic Joint Infection in a Patient with Infected Heart Transplant

Management of Bilateral Synchronous Knee Prosthetic Joint Infection in a Patient with Infected Heart Transplant

Bacterial infections in solid organ transplant recipients

Exebacase: A Novel Approach to the Treatment of Staphylococcal Infections

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