Infectious Diseases and Infestations of the Vulva

Selim, M. Angélica; Parra, Viviana; Sangüeza, Omar P.; Requena, Luis; Sangüeza, Martín

doi:10.1007/978-1-4939-1807-2_6

Cited by 6 publications

(7 citation statements)

References 129 publications

(88 reference statements)

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“…In the control group, HSV1 and HSV2 infections were detected in 3/90 (3.3%), and 0/90 (0%) respectively (p>0.05). Our results agreed with the study done by [17] who observed that only (2%) of 51 pediatric cancer patients were positive for HSV1/2. While in another study done by [18] HSV-1 was detected in 8 cases (25%)…”

Section: Discussionsupporting

confidence: 93%

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Prevalence of Human Herpesviruses (HHV1-7), and its Clinical Significance in Middle Eastern Pediatric Leukemia Patients Using 2 Independent PCR Assays

Mohamed¹,

Aldabbagh²,

Aldughmani³

et al. 2022

Preprint

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Objectives: Human herpes viruses can cause life-threatening diseases in immunocompromised children, especially leukemic patients. Therefore, the aim of this study is to detect the human herpes viruses (HHV1-7) and to investigate its clinical significance in Middle Eastern Pediatric Leukemia Patients by using 2 Independent PCR assays. Methods: Detection of human herpes virus DNA has been done in blood samples of 200 pediatric leukemia patients in addition to 90 blood donors as a control group using multiplex PCR assays. When a ‘‘positive’’ result was observed, real-time PCR was performed to measure the viral load. Results: The most frequent herpes virus infection in Middle Eastern Pediatric Leukemia cases was CMV, followed by EBV, then HHV6, VZV, HHV7, HSV1, and HSV2, where they were 92/200 (46%), 76/200 (38%), 72/200 (36%), 48/200 (24%), 12/200 (6%), 8/200 (4%), and 2/200 (1%) respectively. Also, there was a statistically significance difference between leukemic patients and their controls regarding CMV, EBV, HHV6, and VZV (P <0.05). Correlation between percentage of co-infection, and clinical parameters for the 7 herpes viruses has been studied, and there is an increase in absolute neutrophilic count (ANC), total leukocyte count (TLC) and duration of fever and neutropenia in age group 6-11 years for HHV6/CMV, then in age group 12-18 years especially for EBV/CMV and CMV/HHV6. Also, our results show that multiplex PCR assay is close to single PCR assay in relation to specificity and sensitivity which in turn prove its validity for early diagnosis of herpes viral infection. Conclusions: Adopting multiplex PCR technique is helpful in screening of virus infections. It will save time, effort, cost effective and will assist in rapid diagnosis. However, the clinical relevance of the virus infection needs to be evaluated by quantitative real-time PCR which in turn will help patient's management by using appropriate antiviral treatment.

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Section: Discussionsupporting

confidence: 93%

“…Also, related observations were affirmed by [28]. These results were different from those obtained by [29] who detected only 6 (9%) ALL pediatric cases in bone marrow samples and were also different from [17] who detected HHV6 in (19.6%) of 51 pediatric cancer patients.…”

Section: Discussionmentioning

confidence: 77%

Prevalence of Human Herpesviruses (HHV1-7), and its Clinical Significance in Middle Eastern Pediatric Leukemia Patients Using 2 Independent PCR Assays

Mohamed¹,

Aldabbagh²,

Aldughmani³

et al. 2022

Preprint

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“…Condylomata acuminata may occur as a single lesion but are typically multiple with an elevated papillary and corrugated appearance. They respond well to local treatment, although local recurrences are common …”

Section: Vaginamentioning

confidence: 99%

Sonovaginography: A Useful Technique in the Assessment of the Lower Genital Tract

Johnson

Yegul

Balcacer

2017

J of Ultrasound Medicine

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Conventional sonographic evaluation of the cervix and vagina is compromised by inattention, poor subject contrast, and obscuring artifacts. We describe a technique involving distention of the vaginal canal and fornices with ultrasound gel, providing an acoustic window for improved definition of the cervix and vagina. This exam is usually performed in concert with transvaginal sonography, but a transabdominal or transperineal approach may be more useful in selected scenarios. A wide variety of formerly sonographically inconspicuous conditions are demonstrable with this technique, many of which were undetected or inadequately characterized on the physical exam. Cervical polyps were the most commonly seen abnormality.

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“…[ 19 ] Gamna-Favre bodies: These are large basophilic inclusion bodies, composed of degenerated nuclear material, located in the cytoplasm of endothelial cells in lymphogranuloma venereum. [ 25 ] Glomus bodies: Glomus body is a special arteriovenous shunt or anastomosis formed without the interposition of capillaries that is seen in finger pads, nail beds, palms, and soles. Being located within the reticular dermis and concerned with temperature regulation, it comprises of an afferent arteriole, an anastomotic Sucquet–Hoyer canal, an efferent venule, the intraglomerular reticulum and its capsule.…”

mentioning

confidence: 99%

“…Gamna-Favre bodies: These are large basophilic inclusion bodies, composed of degenerated nuclear material, located in the cytoplasm of endothelial cells in lymphogranuloma venereum. [ 25 ]…”

mentioning

confidence: 99%

A Compendium of Specific Histopathological Bodies in Dermatology

Tiwary¹,

Shah

Madke

et al. 2021

Indian Journal of Dermatology

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The spectrum of histopathological variations of most of the Dermatological conditions is so wide and overlapping that even with our current vast knowledge of this discipline, it seems to be a tough task for clinicians as well as Dermatopathologists to arrive at a conclusive diagnosis in many cases. However, with the aid of special stains and advanced diagnostic techniques, some characteristic histopathologic features have been defined over the time, among which histopathological bodies or inclusion bodies serve as specific clues. With this perspective in view, an attempt has been made to collate and describe the well-known as well as the lesser-known histopathological bodies seen in various dermatological diseases. The underlying pathogenesis and ultramicroscopic features of these structures have also been outlined in brief.

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Infectious Diseases and Infestations of the Vulva

Cited by 6 publications

References 129 publications

Prevalence of Human Herpesviruses (HHV1-7), and its Clinical Significance in Middle Eastern Pediatric Leukemia Patients Using 2 Independent PCR Assays

Prevalence of Human Herpesviruses (HHV1-7), and its Clinical Significance in Middle Eastern Pediatric Leukemia Patients Using 2 Independent PCR Assays

Sonovaginography: A Useful Technique in the Assessment of the Lower Genital Tract

A Compendium of Specific Histopathological Bodies in Dermatology

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