Infection-responsive electrospun nanofiber mat for antibacterial guided tissue regeneration membrane

Shi, Rui; Ye, Jingjing; Li, Weiyang; Zhang, Jingshuang; Li, Jie; Wu, Chengai; Xue, Jiajia; Zhang, Liqun

doi:10.1016/j.msec.2019.03.039

Cited by 45 publications

(41 citation statements)

References 44 publications

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“…GTR membranes with local antibacterial properties are expected to reduce the risk of infections allowing a bacteria-free environment for appropriate tissue regeneration [16]. Several polymeric membranes that can deliver antibiotics at the defect site have been investigated as an alternative to avoid infections during GTR procedures [22][23][24]. However, the use of antibiotics could increase the risk of developing antibiotics-resistant bacteria which is considered an important global problem [25].…”

Section: Page 4 Of 38 Author Submitted Manuscript -Bmm-103219r1mentioning

confidence: 99%

Antibacterial composite membranes of polycaprolactone/gelatin loaded with zinc oxide nanoparticles for guided tissue regeneration

et al. 2020

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Section: Page 4 Of 38 Author Submitted Manuscript -Bmm-103219r1mentioning

confidence: 99%

Antibacterial composite membranes of polycaprolactone/gelatin loaded with zinc oxide nanoparticles for guided tissue regeneration

et al. 2020

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“…Besides such material components, various anti-microbial medicines have been applied to scaffolds that include tetracycline, doxycycline and metronidazole. Shi et al reported that metronidazole conjugated electrospun nanofibers enhanced antibacterial capacity [ 49 ]. Chang et al reported that core-shell poly-(D, l -Lactide- co -Glycolide) (PLGA)-chitosan nanospheres encapsulated with doxycycline inhibits P. gingivalis and S. sanguinis [ 50 ].…”

Section: Purpose Of Use Of Biomaterials Scaffolds For Periodontal Regementioning

confidence: 99%

The recent advances in scaffolds for integrated periodontal regeneration

Woo

Cho

Tarafder

et al. 2021

Bioactive Materials

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The periodontium is an integrated, functional unit of multiple tissues surrounding and supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be destructed by chronic periodontal disease, which can lead to tooth loss. In support of the treatment for periodontally diseased tooth, various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration (GTR) that is the current gold standard in dental clinic. Recently, various biomaterials have been prepared in a form of tissue engineering scaffold to facilitate the regeneration of damaged periodontal tissues. From a physical substrate to support healing of a single type of periodontal tissue to multi-phase/bioactive scaffold system to guide an integrated regeneration of periodontium, technologies for scaffold fabrication have emerged in last years. This review covers the recent advancements in development of scaffolds designed for periodontal tissue regeneration and their efficacy tested in vitro and in vivo . Pros and Cons of different biomaterials and design parameters implemented for periodontal tissue regeneration are also discussed, including future perspectives.

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“…For the regeneration of periodontal ligament, numerous nanomaterials are listed as candidates and have been extensively studied. For instance, electrospun nanofibrous made by electrospinning polymer nanofibrous membrane (He et al, 2017; Shi et al, 2019; Xue et al, 2014), PLGA (Liao et al, 2005), gelatin (Munchow et al, 2015; Xue et al, 2014), and PLLA (Mei et al, 2007) has been suggested for GTR to control periodontal infection. Furthermore, in order to mimic the complicated structure of periodontal tissue and satisfy different functions, two‐layered and three‐layered membranes have been developed.…”

Section: Tissue Regenerationmentioning

confidence: 99%

Advances of nanomaterial applications in oral and maxillofacial tissue regeneration and disease treatment

Ding

Cui

Shen

et al. 2020

WIREs Nanomed Nanobiotechnol

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Using bioactive nanomaterials in clinical treatment has been widely aroused. Nanomaterials provide substantial improvements in the prevention and treatment of oral and maxillofacial diseases. This review aims to discuss new progresses in nanomaterials applied to oral and maxillofacial tissue regeneration and disease treatment, focusing on the use of nanomaterials in improving the quality of oral and maxillofacial healthcare, and discuss the perspectives of research in this arena. Details are provided on the tissue regeneration, wound healing, angiogenesis, remineralization, antitumor, and antibacterial regulation properties of nanomaterials including polymers, micelles, dendrimers, liposomes, nanocapsules, nanoparticles and nanostructured scaffolds, etc. Clinical applications of nanomaterials as nanocomposites, dental implants, mouthwashes, biomimetic dental materials, and factors that may interact with nanomaterials behaviors and bioactivities in oral cavity are addressed as well. In the last section, the clinical safety concerns of their usage as dental materials are updated, and the key knowledge gaps for future research with some recommendation are discussed. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement

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Infection-responsive electrospun nanofiber mat for antibacterial guided tissue regeneration membrane

Cited by 45 publications

References 44 publications

Antibacterial composite membranes of polycaprolactone/gelatin loaded with zinc oxide nanoparticles for guided tissue regeneration

Antibacterial composite membranes of polycaprolactone/gelatin loaded with zinc oxide nanoparticles for guided tissue regeneration

The recent advances in scaffolds for integrated periodontal regeneration

Advances of nanomaterial applications in oral and maxillofacial tissue regeneration and disease treatment

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