Infection of β-herpesviruses (CMV, HHV-6, HHV-7): role in postrenal transplantation complications

Association of HHV-6 and HHV-7 reactivation with the development of chronic allograft nephropathy

“…13,14 The development of CMV disease in the patients with CMV and HHV-7 and CMV, HHV-6 and HHV-7 infection suggests that HHV-6 and HHV-7 may be co-factors of this disease in consequence of a synergistic effect. The association of HHV-6 and HHV-7 infection with an increased risk for development of CMV disease in the renal transplant patients is reported previously.…”

“…The kinetics of the activation of these viruses during the post-transplantation period suggest that HHV-7 may act as a co-factor for HHV-6 and CMV reactivation, while both HHV-6 and HHV-7 may act as co-factors in the pathogenesis of CMV disease and acute rejection. [12][13][14][15][16] The aim of this study was to determine HHV-6 and HHV-7 activation during the post-transplantation period and to evaluate the possible effects of the activation of these viruses on CAN development in renal transplant patients.…”

Longitudinal Study of Herpesviruses in Kidney Transplant Recipients in Cuba

“…HHV-6 has recently been recognized as an opportunistic pathogen in transplant recipients; infection with HHV-6 has been documented in 38%-55% of renal transplant recipients and in 31% of liver transplant recipients. Most infections occur 2-4 weeks after transplantation, and prompt recognition of disease associated with the virus is important, because HHV-6 is susceptible to currently available antiviral agents [3,4].…”

Sensitivity and Reproducibility of Polymerase Chain Reaction Assays for Detection of Human Herpesviruses 6 and 7

“…Both of the viruses are highly prevalent in the healthy population, establishing latency in the human host after the primary infection, and can become reactivated in immunosuppressive individuals (Chapenko et al, 2001;Kozireva et al, 2001). …”

“…HHV-6 (A and B variants) reactivation occurs in approximately 50% of bone marrow and solid organ transplant recipients. The consequences of HHV-6 reactivation include cytomegalovirus (CMV) reactivation, bone marrow suppression, central nervous system dysfunction, idiopathic pneumonitis, severe graft-versus-host disease, hepatitis fulminant liver failure and increased mortality (Chapenko et al, 2001;Caselly et al, 2007).…”