Association of HHV-6 and HHV-7 reactivation with the development of chronic allograft nephropathy

Chapenko, Svetlana; Folkmane, Inese; Ziedina, Ieva; Chistyakovs, M.; Rozentāls, Rafails; Krūmiņa, Angelika; Murovska, Modra

doi:10.1016/j.jcv.2009.05.018

Cited by 32 publications

(23 citation statements)

References 31 publications

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“…Asymptomatic HHV-6 reactivations predominate in the post-HSCT setting. Previously, we investigated the role of HHV-6 and HHV-7 in development of complications after renal transplantation and showed that HHV-7 acts as a co-factor for HHV-6 and CMV reactivation, while both HHV-6 and HHV-7 act as co-factors in the pathogenesis of CMV disease, acute rejection and chronic allograft nephropathy , Chapenko et al, 2009. In the present study we examined presence of beta-herpesviruses and EBV infection in patients with auto-and allo-transplatation of peripheral blood stem cells, which allowed to estimate significance of infection activation of each virus and its relationship with development of complications.…”

Section: Effect Of Hhv-6 and Hhv-7 Infection On The Post-transplant Pmentioning

confidence: 99%

Effect of HHV-6 and HHV-7 Infection on the Posttransplant Process and the Development of Complications in Patients after Autologous Stem Cell Transplantation / HHV-6 Un HHV-7 Infekcijas Ietekme Uz Pēctransplantācijas Klīnisko Gaitu Un Komplikāciju Attīstību Pacientiem Pēc Autologas Cilmes Šūnu Transplantācijas

Trociukas

Èapenko

Zazerska

et al. 2016

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Communicated by Ludmila VîksnaThe relationship between HHV-6 and HHV-7 reactivation and development of post-autologous peripheral stem cell transplantation complications was examined. The presence of viral genomic sequences in whole peripheral blood and cell free plasma was determined by nested PCR, load by real-time PCR, virus specific antibodies and cytokines in serum by ELISA, and HHV-6 variants by restriction endonuclease analysis. Clinical features, reactivation of viruses and serum TNF-a, and IL-6 concentrations were determined in seventy-six patients with Roseolovirus infection before and after transplantation. Anti-HHV-6 antibodies were found in 62 of 76 (81.6%) patients before transplantation. A significantly higher rate of single HHV-7 infection was found in patients with viral infection in comparison with single HHV-6 infection (p = 0.0003) and concurrent (HHV-6 and HHV-7) infection (p = 0.0017). Complications after transplantation developed in 30.3% of patients and reactivation of viruses was detected in all of these patients. Significant increase of HHV-6 and HHV-7 reactivation with simultaneous increase of pro-inflammatory cytokines serum levels suggests that both viruses may be involved in the development of complications after autologous peripheral blood stem cell transplantation via their immunomodulatory ability. The kinetics of the Roseolovirus reactivation may reflect the potential role of HHV-7 as a co-factor for

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Section: Effect Of Hhv-6 and Hhv-7 Infection On The Post-transplant Pmentioning

confidence: 99%

Effect of HHV-6 and HHV-7 Infection on the Posttransplant Process and the Development of Complications in Patients after Autologous Stem Cell Transplantation / HHV-6 Un HHV-7 Infekcijas Ietekme Uz Pēctransplantācijas Klīnisko Gaitu Un Komplikāciju Attīstību Pacientiem Pēc Autologas Cilmes Šūnu Transplantācijas

Trociukas

Èapenko

Zazerska

et al. 2016

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…Human herpesvirus-6 has also been associated with liver allograft rejection and chronic allograft nephropathy [24,27,34,54,[87][88][89]. In liver transplantation, intragraft HHV-6 infection has been associated with portal lymphocyte infiltration and increase of vascular adhesion molecules, such as ICAM-1 and VCAM-1, known to be important in leukocyte extravasation and lymphocyte activation [87].…”

Section: Indirect Effects Of Hhv-6mentioning

confidence: 99%

“…Kidney transplant recipients Asymptomatic HHV-6 reactivation in the majority of patients; clinical disease only in an estimated 1% of patients Direct effects: fever, rash, renal dysfunction such as a rise in serum creatinine, hepatitis and liver dysfunction, gastrointestinal symptoms including colitis, hemophagocytosis syndrome, and encephalitis [54,62,63,64,65,66] Indirect effects: Acute and chronic rejection including chronic allograft nephropathy, higher rates of CMV disease [27,30,49,89] Liver transplant recipients Asymptomatic HHV-6 reactivation in the majority of patients; clinical disease occurs in an estimated 1% of patients Direct effects: fever, rash, thrombocytopenia, neurologic abnormality including encephalopathy, hepatitis including giant cell hepatitis, gastrointestinal illness such as dyspepsia, pneumonia [23,26,27,32,36,45,48,52,55,71] Indirect effects: Higher rates of CMV disease, accelerated HCV recurrence, higher rates of invasive fungal diseases [34,60,62,[81][82][83][84][85][86] Heart and lung transplant recipients Incidence is not fully defined, but reactivation is presumed to be mostly asymptomatic Direct effects: Pneumonia, encephalitis, colitis, giant cell hepatitis [43,47,53,76,77] Indirect effects: bronchiolitis obliterans syndrome, higher all-cause mortality [42,73] Notes: HHV-6, human herpesvirus 6; CMV, cytomegalovirus; HCV, hepatitis C virus.…”

Section: Transplant Type Hhv-6 Effects Referencesmentioning

confidence: 99%

Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: review

Lautenschlager

Razonable

2012

Transplant International

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Summary Human herpesvirus‐6 (HHV‐6), which comprises of HHV‐6A and HHV‐6B, is a common infection after solid organ transplantation. The rate of HHV‐6 reactivation is high, although clinical disease is not common. Only 1% of transplant recipients will develop clinical illness associated with HHV‐6 infection, and most are ascribable to HHV‐6B. Fever, myelosuppression, and end‐organ disease, including hepatitis and encephalitis, have been reported. HHV‐6 has also been associated with various indirect effects, including a higher rate of CMV disease, acute and chronic graft rejection, and opportunistic infection such as invasive fungal disease. All‐cause mortality is increased in solid organ transplant recipients with HHV‐6 infection. HHV‐6 is somewhat unique among human viruses because of its ability to integrate into the host chromosome. The clinical significance of chromosomally integrated HHV‐6 is not yet defined, although a higher rate of bacterial infection and allograft rejection has been suggested. The diagnosis of HHV‐6 is now commonly made using nucleic acid testing for HHV‐6 DNA in clinical samples, but this can be difficult to interpret owing to the common nature of asymptomatic viral reactivation. Treatment of HHV‐6 is indicated in established end‐organ disease such as encephalitis. Foscarnet, ganciclovir, and cidofovir have been used for treatment.

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“…Concurrent intragaft infections of HHV-6 and CMV have been found both in kidney transplants [6]. Finally, both HHV-6 and HHV-7 infections are associated with the development of chronic allograft nephropathy [10].…”

mentioning

confidence: 97%

Is Isolation of Human Herpesvirus 6 in Kidney Transplant Recipients Clinically Significant?

Kelesidis¹

2012

J Transplant Technol Res

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Association of HHV-6 and HHV-7 reactivation with the development of chronic allograft nephropathy

Cited by 32 publications

References 31 publications

Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: review

Is Isolation of Human Herpesvirus 6 in Kidney Transplant Recipients Clinically Significant?

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