Infection of mice concurrently withSchistosoma mansoniand rodent malarias: contrasting effects of patentS. mansoniinfections onPlasmodium chabaudi, P. yoeliiandP. berghei

Lwin, Myint; Targett, G. A. T.; Doenhoff, Michael J.

doi:10.1080/00034983.1982.11687541

Cited by 39 publications

(21 citation statements)

References 16 publications

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“…Marshall et al (1999) found increased plasma TNF-α and increased hepatotoxicity in mice with combined S. mansoni and T. gondii infections and this effect was diminished in IL-12 ko mice (Araujo et al 2001). The susceptibility to Plasmodium yoelli and P. berghei was little affected (Lwin et al 1982).…”

Section: Interaction Of Schistosomiasis With Other Diseasesmentioning

confidence: 99%

Experimental models of Schistosoma mansoni infection

Cheever

Lenzi²,

Lenzi³

et al. 2002

Mem. Inst. Oswaldo Cruz

121

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Section: Interaction Of Schistosomiasis With Other Diseasesmentioning

confidence: 99%

Experimental models of Schistosoma mansoni infection

Cheever

Lenzi²,

Lenzi³

et al. 2002

Mem. Inst. Oswaldo Cruz

121

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“…leads to a two-fold increase in parasitaemia, as compared to what is observed for a single malarial infection (Lwin et al 1982). More recently, it has been reported that superinfection with S. mansoni enhances the development of Plasmodium berghei, increases both parasitaemia and mortality and delays the reduction/ clearance in parasitaemia (Legesse et al 2004).…”

mentioning

confidence: 99%

Reduced protective effect of Plasmodium berghei immunization by concurrent Schistosoma mansoni infection

Laranjeiras

Brant

Lima

et al. 2008

Mem. Inst. Oswaldo Cruz

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“…Although some animal studies have shown that chronic schistosomiasis protects against severe malaria (5), others have reported that a concurrent schistosome infection enhances the severity of malaria (6)(7)(8)(9)(10). Many factors may account for these differences, including mouse strain, duration and intensity of the helminth infection, Plasmodium strain or species, inoculum size, or route of malaria infection (skin or blood stage) (11).…”

mentioning

confidence: 99%

Protective Effect of Chronic Schistosomiasis in Baboons Coinfected with Schistosoma mansoni and Plasmodium knowlesi

et al. 2016

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c Malaria and schistosomiasis coinfections are common, and chronic schistosomiasis has been implicated in affecting the severity of acute malaria. However, whether it enhances or attenuates malaria has been controversial due the lack of appropriately controlled human studies and relevant animal models. To examine this interaction, we conducted a randomized controlled study using the baboon (Papio anubis) to analyze the effect of chronic schistosomiasis on severe malaria. Two groups of baboons (n ‫؍‬ 8 each) and a schistosomiasis control group (n ‫؍‬ 3) were infected with 500 Schistosoma mansoni cercariae. At 14 and 15 weeks postinfection, one group was given praziquantel to treat schistosomiasis infection. Four weeks later, the two groups plus a new malaria control group (n ‫؍‬ 8) were intravenously inoculated with 10 5 Plasmodium knowlesi parasites and monitored daily for development of severe malaria. A total of 81% of baboons exposed to chronic S. mansoni infection with or without praziquantel treatment survived malaria, compared to only 25% of animals infected with P. knowlesi only (P ‫؍‬ 0.01). Schistosome-infected animals also had significantly lower parasite burdens (P ‫؍‬ 0.004) than the baboons in the P. knowlesi-only group and were protected from severe anemia. Coinfection was associated with increased spontaneous production of interleukin-6 (IL-6), suggesting an enhanced innate immune response, whereas animals infected with P. knowlesi alone failed to develop mitogen-driven tumor necrosis factor alpha and IL-10, indicating the inability to generate adequate protective and balancing immunoregulatory responses. These results indicate that chronic S. mansoni attenuates the severity of P. knowlesi coinfection in baboons by mechanisms that may enhance innate immunity to malaria. P olyparasitism is common in low-resource countries, especially in sub-Saharan Africa. Coinfections may alter disease outcomes and affect both drug and vaccine efficacies (1, 2). The majority of studies on coinfections have focused on interactions between malaria and chronic helminth infections. Interest in studying malaria and schistosomiasis, in particular, comes from the major overlap of the two diseases in areas where they are endemic and the fact that these infections account for a large proportion of global morbidity and mortality (3, 4). Because of the chronicity of schistosome infection, most studies have focused on its impact on susceptibility to clinical malaria.Studies on malaria and schistosomiasis coinfections in human and animal models have generated contradicting results. Although some animal studies have shown that chronic schistosomiasis protects against severe malaria (5), others have reported that a concurrent schistosome infection enhances the severity of malaria (6-10). Many factors may account for these differences, including mouse strain, duration and intensity of the helminth infection, Plasmodium strain or species, inoculum size, or route of malaria infection (skin or blood stage) (11). An important limitat...

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Infection of mice concurrently withSchistosoma mansoniand rodent malarias: contrasting effects of patentS. mansoniinfections onPlasmodium chabaudi, P. yoeliiandP. berghei

Cited by 39 publications

References 16 publications

Experimental models of Schistosoma mansoni infection

Experimental models of Schistosoma mansoni infection

Reduced protective effect of Plasmodium berghei immunization by concurrent Schistosoma mansoni infection

Protective Effect of Chronic Schistosomiasis in Baboons Coinfected with Schistosoma mansoni and Plasmodium knowlesi

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