Infection Monitoring in Wounds

Schröter, A.; Walther, Anja; Fritzsche, Kenneth; Kothe, J.; Rösen‐Wolff, Angela; Gerlach, Gerald

doi:10.1016/j.proche.2012.10.144

Cited by 6 publications

(8 citation statements)

References 11 publications

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“…Given the importance of pH to a range of biochemical processes, including the activity of proteolytic enzymes, the ability to monitor pH and modulate it (through treatments and dressings) could be advantageous. New technologies are emerging to enable monitoring of pH in wounds, based upon electrochemical methods using potentiometric and voltammetric methodologies [9][10][11], inductance-based pH responsive hydrogels [12], optical fiber based sensors [13], and luminescence approaches through sensor films [14]. Investigators have also tried to elucidate whether there is a spatial disparity to pH.…”

Section: Ph: a Key Biomarker?mentioning

confidence: 99%

Could In-situ Analysis Help Unravel the Biochemical Milieu of Chronic Wounds?

Sharp¹

2014

SOJB

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Section: Ph: a Key Biomarker?mentioning

confidence: 99%

Could In-situ Analysis Help Unravel the Biochemical Milieu of Chronic Wounds?

Sharp¹

2014

SOJB

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“…With the spread of antimicrobial resistance, infection causes increased wound chronicity and risks of gangrene and amputation, creating a burden on patients and healthcare providers worldwide [ 5 , 6 , 7 ]. Continuous chronic wound monitoring is therefore a promising strategy to enable early detection of infection, aid diagnosis and inform therapeutic decisions [ 8 , 9 , 10 ]. At the same time, reliable wound monitoring devices are still hardly realised, due to the complex infection mechanisms and healing process of these wounds [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Continuous chronic wound monitoring is therefore a promising strategy to enable early detection of infection, aid diagnosis and inform therapeutic decisions [ 8 , 9 , 10 ]. At the same time, reliable wound monitoring devices are still hardly realised, due to the complex infection mechanisms and healing process of these wounds [ 9 ]. Aiming at next-generation wound care, multifunctional cost-effective wound management products are therefore needed to support healing in non-self-healing wounds and to signal the occurrence of infection by e.g., visual effects [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response

Bazbouz

Tronci

2019

Sensors

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The spread of antimicrobial resistance calls for chronic wound management devices that can engage with the wound exudate and signal infection by prompt visual effects. Here, the manufacture of a two-layer fibrous device with independently-controlled exudate management capability and visual infection responsivity was investigated by sequential free surface electrospinning of poly(methyl methacrylate-co-methacrylic acid) (PMMA-co-MAA) and poly(acrylic acid) (PAA). By selecting wound pH as infection indicator, PMMA-co-MAA fibres were encapsulated with halochromic bromothymol blue (BTB) to trigger colour changes at infection-induced alkaline pH. Likewise, the exudate management capability was integrated via the synthesis of a thermally-crosslinked network in electrospun PAA layer. PMMA-co-MAA fibres revealed high BTB loading efficiency (>80 wt.%) and demonstrated prompt colour change and selective dye release at infected-like media (pH > 7). The synthesis of the thermally-crosslinked PAA network successfully enabled high water uptake (WU = 1291 ± 48 − 2369 ± 34 wt.%) and swelling index (SI = 272 ± 4 − 285 ± 3 a.%), in contrast to electrospun PAA controls. This dual device functionality was lost when the same building blocks were configured in a single-layer mesh of core-shell fibres, whereby significant BTB release (~70 wt.%) was measured even at acidic pH. This study therefore demonstrates how the fibrous configuration can be conveniently manipulated to trigger structure-induced functionalities critical to chronic wound management and monitoring.

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Section: Introductionmentioning

confidence: 99%

“…A multi-parametric sensor was developed by Schröter et al (2012) to determine the bacterial infection via formation of neutrophil extracellular traps (NET) that are indicative of bacterial infection. An electrode array was assembled with different functional isonicotinylhydrazine (INH) attaches the neutrophils that comes in contact with them (Schröter et al, 2012). Electrode arrays were designed using techniques like physical vapor deposition process, lithography and spin coating, and interdigitated electrode configuration prevented artifacts via production of high field strength at the surface of sensor, and field distribution was maintained.…”

Section: Introductionmentioning

confidence: 99%

Real-time wound management through integrated pH sensors: a review

Khan¹,

Ansari²,

Ali³

2015

Sensor Review

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If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service information about how to choose which publication to write for and submission guidelines are available for all. Please visit www.emeraldinsight.com/authors for more information. About Emerald www.emeraldinsight.comEmerald is a global publisher linking research and practice to the benefit of society. The company manages a portfolio of more than 290 journals and over 2,350 books and book series volumes, as well as providing an extensive range of online products and additional customer resources and services.Emerald is both COUNTER 4 and TRANSFER compliant. The organization is a partner of the Committee on Publication Ethics (COPE) and also works with Portico and the LOCKSS initiative for digital archive preservation. AbstractPurpose -Real-time monitoring of wound or injured tissues is critical for speedy recovery, and the onset of a cascade of biochemical reactions provides potential biomarkers that facilitate the process of wound monitoring, e.g. pH, temperature, moisture level, bacterial load, cytokines, interleukins, etc. Among all the biomarkers, pH has been known to have a profound impact on the wound healing process, and is used to determine the incidence of bacterial infection of the wound (persistently elevated alkaline pH), proteolytic activity at the site of injury, take rate in skin grafting, wound healing stage and preparation for wound debridement. Design/methodology/approach -This review highlights the significance of pH in determination of clinical parameters and for selection of an appropriate treatment regime, and it presents an in-depth analysis of the designs and fabrication methods that use integrated pH sensors, which have been reported to date for the real-time monitoring of wound healing. Findings -For an expedited wound healing process, the significance of pH mandated the need of an integrated sensor system that would facilitate real-time monitoring of healing wounds and obviate the requirement of redressing or complicated testing procedures, which are both labor-intensive and painful for the patient. The review also discussed different types of sensor systems which were developed using hydrogel as a pH-responsive system coupled with voltammetry, potentiometry, impedimetric and flex-circuit inductive transducer systems. All of the mentioned devices have considerable potential for clinical applications, and there is need of in vivo testing to validate their efficiency and sensitivity under practical scenarios. Originality/value -This manuscript is an original review of literature, and permission has been granted to use the figures from previously published papers.

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Infection Monitoring in Wounds

Cited by 6 publications

References 11 publications

Could In-situ Analysis Help Unravel the Biochemical Milieu of Chronic Wounds?

Could In-situ Analysis Help Unravel the Biochemical Milieu of Chronic Wounds?

Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response

Real-time wound management through integrated pH sensors: a review

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