Could In-situ Analysis Help Unravel the Biochemical Milieu of Chronic Wounds?

Sharp, Duncan

doi:10.15226/2376-4589/1/1/00106

Cited by 1 publication

(2 citation statements)

References 29 publications

(31 reference statements)

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“…Upon infection, the local temperature of the wound rises because of an increase in blood flow to the surrounding tissue . Additionally, the pH of an open wound can range from 6.5 to 8.8 8 and can become more acidic or more basic upon infection, depending on the type of bacteria that infects the wound bed. − Therefore, wound pH and temperature are measures that can be exploited as indicators of infection. , Controlled release drug delivery systems are designed to deliver the drug to the target site at a desired rate. , Although research has led to the development of wound dressings for direct placement on a wound for continual release of therapeutics to treat an infection, , research investigating the controlled release of therapeutics from wound dressings in response to infection due to changes in the wound environment, i.e., temperature and pH, is scarce . Further research into an infection responsive antibiotic releasing material could lead to the effective early treatment of infection.…”

Section: Introductionmentioning

confidence: 56%

“…8−11 Therefore, wound pH and temperature are measures that can be exploited as indicators of infection. 12,13 Controlled release drug delivery systems are designed to deliver the drug to the target site at a desired rate. 14,15 Although research has led to the development of wound dressings for direct placement on a wound for continual release of therapeutics to treat an infection, 16,17 research investigating the controlled release of therapeutics from wound dressings in response to infection due to changes in the wound environment, i.e., temperature and pH, is scarce.…”

Section: Introductionmentioning

confidence: 99%

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Stimulus-Responsive Antibiotic Releasing Systems for the Treatment of Wound Infections

Schultz

Vasani

Holmes

et al. 2019

ACS Appl. Bio Mater.

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There remains an unmet need for innovative treatments for chronic wound infections as they continue to be a financial and social burden on society. Because of the dynamic nature of wounds, this study investigated the utilization of stimulus-responsive plasma polymers for the development of pH- and thermoresponsive antibiotic delivery systems for the treatment of wound infections. Porous silicon films were loaded with the antibiotic levofloxacin (LVX) and subsequently coated with plasma polymer layers: first, poly(1,7-octadiene) (pOCT) for stability, followed by either the temperature-responsive polymer poly N,N-diethylacrylamide (pDEA) or the pH- responsive polymer poly 2-(diethylamino)ethyl methacrylate (pDEAEMA), to fabricate two delivery systems. The delivery systems were thoroughly characterized chemically and physically and tested in vitro through drug release and bacterial zone of inhibition studies. After a 16 h time point, the system containing pDEA achieved 3.2-fold greater release at 45 °C compared to 22 °C, whereas the system containing pDEAEMA achieved a 2.2-fold greater release when exposed to pH 8.5 media compared to pH 6.2 media. Furthermore, both systems retained their antimicrobial activity and demonstrated stimulus-responsive release to form zones of inhibition on relevant wound pathogens, Pseudomonas aeruginosa, Staphylococcus epidermidis and Staphylococcus aureus. Therefore, this proof-of-principle study confirms that stimulus-responsive porous silicon films can be utilized to deliver antibiotic when exposed to physiologically relevant stimuli such as pH and temperature with the potential to be applied to other pharmaceutics.

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