Infection by Mycobacterium haemophilum, a metabolically fastidious acid-fast bacillus

Moulsdale, M.; Harper, J. R.; Thatcher, G.N.; Dunn, Beth L.

doi:10.1016/0041-3879(83)90047-8

Cited by 39 publications

(28 citation statements)

References 8 publications

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“…Therefore, the in vitro susceptibilities presented in Table 5 are approximations. M. haemophilum appears to be susceptible to ciprofloxacin, clarithromycin, rifabutin, and clofazimine but resistant to isoniazid and ethambutol (96,105,126,141 (9). Interesting results were obtained for cycloserine, with an MIC 50 of 50 g/ml.…”

Section: Antimicrobial Susceptibilitymentioning

confidence: 55%

Clinical Manifestations, Diagnosis, and Treatment of Mycobacterium haemophilum Infections

et al. 2011

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SUMMARY Mycobacterium haemophilum is a slowly growing acid-fast bacillus (AFB) belonging to the group of nontuberculous mycobacteria (NTM) frequently found in environmental habitats, which can colonize and occasionally infect humans and animals. Several findings suggest that water reservoirs are a likely source of M. haemophilum infections. M. haemophilum causes mainly ulcerating skin infections and arthritis in persons who are severely immunocompromised. Disseminated and pulmonary infections occasionally occur. The second at-risk group is otherwise healthy children, who typically develop cervical and perihilar lymphadenitis. A full diagnostic regimen for the optimal detection of M. haemophilum includes acid-fast staining, culturing at two temperatures with iron-supplemented media, and molecular detection. The most preferable molecular assay is a real-time PCR targeting an M. haemophilum -specific internal transcribed spacer (ITS), but another approach is the application of a generic PCR for a mycobacterium-specific fragment with subsequent sequencing to identify M. haemophilum . No standard treatment guidelines are available, but published literature agrees that immunocompromised patients should be treated with multiple antibiotics, tailored to the disease presentation and underlying degree of immune suppression. The outcome of M. haemophilum cervicofacial lymphadenitis in immunocompetent patients favors surgical intervention rather than antibiotic treatment.

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Section: Antimicrobial Susceptibilitymentioning

confidence: 55%

Clinical Manifestations, Diagnosis, and Treatment of Mycobacterium haemophilum Infections

et al. 2011

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“…To date, all infections have occurred in immunosuppressed individuals, notably renal transplant recipients (Sompolinsky et al 1978;Mezo et al 1979;Dawson & Jennis, 1980;Davis et al 1982;Branger et al 1983;Moulsdale et al 1983). In one report the infection was initially thought to be due to M. marinum as the patient's daughter had kept goldfish that had died during the preceding year (Moulsdale et al 1983). In view of the occurrence of such infections it appears advisable to inoculate skin biopsies, particularly if they are from immunosuppressed patients, on to media supplemented with ferric ammonium citrate as well as on standard media.…”

Section: Cutaneous Infections Caused By Other Mycobacteriamentioning

confidence: 99%

Mycobacterium marinuminfections in man

Collins

Grange

Noble

et al. 1985

J. Hyg.

101

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Mycobacterium marinum, formerly known as ‘Mycobacterium balnei’, is a free-living organism which causes disease in fish and occasionally in man. When such infections occur in man they are usually associated with some aquatic activity, e.g. swimming, fishing, boating and keeping tropical fish. For this reason, the organism has been called a ‘leisure-time pathogen’ by Feldman, Long & David (1974) and the disease a ‘hobby hazard’ by Heineman, Spitzer & Pianphongsant (1972).

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“…First, it has a requirement for hemin or ferric ammonium citrate (122,367,397,433,469,470). Neither mycobactin nor ferric chloride could replace hemin or ferric ammonium citrate (122).…”

Section: Characteristics Of M Haemophilummentioning

confidence: 99%

“…M. haemophilum is of low virulence. Animals inoculated with M. haemophilum develop few if any signs of infection (1,367,469), with the exception of amphibians (469) and unless the animals have been treated with steroids (1). The low virulence of M. haemophilum for laboratory animals, except amphibians, may be due to a restriction of growth provided by the animal's body temperature.…”

Section: Characteristics Of M Haemophilummentioning

confidence: 99%