<i>Mycobacterium marinum</i>infections in man

Collins, C.H.; Grange, John M.; Noble, W. C.; Yates, M.D.

doi:10.1017/s0022172400061349

Cited by 101 publications

(65 citation statements)

References 84 publications

(58 reference statements)

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“…The patient was known to visit public indoor swimming pools frequently. M. marinum is the NTM species most commonly responsible for this kind of soft-tissue infection, which is also known by the name of "fish tank granuloma" [13,104]. An outbreak of 80 cases of granulomatous skin lesions acquired in a swimming pool in Sweden was described by Linell and Norden in 1954 [105].…”

Section: Site Of Mycobacteriosismentioning

confidence: 99%

Epidemiology and Clinical Significance of Nontuberculous Mycobacteria in Patients Negative for Human Immunodeficiency Virus in Switzerland

Debrunner

Brändli

Graevenitz

1992

Clinical Infectious Diseases

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Section: Site Of Mycobacteriosismentioning

confidence: 99%

Epidemiology and Clinical Significance of Nontuberculous Mycobacteria in Patients Negative for Human Immunodeficiency Virus in Switzerland

Debrunner

Brändli

Graevenitz

1992

Clinical Infectious Diseases

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“…In humans it is the causative agent of a disease called swimming pool granuloma (7,42). However, a recent case study expanded the spectrum of infections caused by M. marinum to granulomatous pulmonary disease in humans (22).…”

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confidence: 99%

A Mycobacterial Gene Involved in Synthesis of an Outer Cell Envelope Lipid Is a Key Factor in Prevention of Phagosome Maturation

et al. 2007

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Virulent mycobacteria cause arrest of phagosome maturation as a part of their survival strategy in hosts. This process is mediated through multiple virulence factors, whose molecular nature remains elusive. Using Mycobacterium marinum as a model, we performed a genome-wide screen to identify mutants whose ability to inhibit phagosome maturation was impaired, and we succeeded in isolating a comprehensive set of mutants that were not able to occupy an early endosome-like phagosomal compartment in mammalian macrophages. Categorizing and ordering the multiple mutations according to their gene families demonstrated that the genes modulating the cell envelope are the principal factors in arresting phagosome maturation. In particular, we identified a novel gene, pmiA, which is capable of influencing the constitution of the cell envelope lipids, thereby leading to the phagosome maturation block. The pmiA mutant was not able to resist phagosome maturation and was severely attenuated in mice. Complementing the mutant with the wild-type gene restored the attenuated virulence to wild-type levels in mice.Mycobacterium tuberculosis, the causative agent of tuberculosis, claims the lives of over 1.7 million people per year. An estimated one-third of the world's population is infected with the tuberculosis bacillus (43). The predilection of virulent mycobacteria to dwell in a hostile environment (macrophages) is considered central for effective pathogenesis. The mycobacteria persist inside macrophages by occupying an early endosome-like phagosomal compartment and avoiding the default pathway of phagosome maturation (PM) (3). Phagosomes containing mycobacteria do not have pH values below pH 6.2 and are characterized by the absence of lysosome-associated membrane protein and lysosomal hydrolases, reduced levels of ATPase, and retention of the early endosomal markers Rab5 and TACO or mouse coronin (12,30,40). Phagosomal factors that mediate the killing of mycobacteria at different stages have been described previously (2).Although several host cell mechanisms involved in the inhibition of PM have been proposed, an explanation for how mycobacteria establish a safe haven for themselves in the hostile environment in macrophages remains elusive. Possible roles for mycobacterial urease (17) and lipoarabinomannan in impeding phagosome acidification have been postulated (37). Mycobacterial protein kinase G was shown to prevent transfer of mycobacteria to lysosomes (41). Mycobacterial phosphoinositol mannosides that are similar to the mammalian phosphoinositol lipids enhance fusion of phagosomes containing mycobacteria with early endosomes (39). In addition, Vergne and colleagues identified a secreted mycobacterial lipid phosphatase (SapM) that hydrolyzes phosphoinositol-3-phosphate, leading to inhibition of PM (38). Pathogenic mycobacteria induce disruption of the actin filament network regulated by p38 mitogen-activated protein kinases, but the effector molecules have not been elucidated (2, 18). The close apposition of the mycobacterial...

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“…The infection is frequently linked with minor skin abrasions. First of all M. marinum is associated with swimming pool granuloma outbreaks [101]. Respiratory system disorders (hypersensitivity pneumonitis, hot tub lung) have also been associated with mycobacteria, first of all with MAC mostly in connection to the use of poorly maintained and non-disinfected spa pools [102,103].…”

Section: Biofilm Mediated Organismsmentioning

confidence: 99%

The risk of contracting infectious diseases in public swimming pools. A review

Barna

Kádár

2012

Annali Dell'Istituto Superiore Di Sanità

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Summary.A review of pathogenic microorganisms presenting risk of infection in pool based artificial recreational water venues is extracted from the available scientific literature. The microorganisms are grouped both according to their way of spread and their survival and growth strategies and their characteristics relevant for the pool and spa based recreation are discussed. In order to put the proposed risks on a solid basis, among others a ten year excerpt of the waterborne disease statistics of the Centers for Disease Control and Prevention (CDC) is used throughout the article.Key words: man-made water recreational environment, risk of infection, waterborne disease outbreaks, swimming pool, hot tub.Riassunto (Il rischio di contrarre malattie infettive nelle piscine pubbliche. Una rassegna). Viene presentata una sintesi della letteratura scientifica disponibile sui microorganismi patogeni potenzialmente infettivi, in ambienti acquatici ricreativi artificiali, come le piscine. I microorganismi sono raggruppati sia in base alle loro vie di diffusione che in base alle loro strategie di sopravvivenza e di crescita; successivamente vengono discusse le loro caratteristiche più importanti negli ambienti ricreativi considerati, piscine e terme. Per fornire adeguate e solide basi scientifiche ai tipi di rischi presentati, vengono analizzate, oltre ad altri documenti, le statistiche relative a dieci anni di osservazione di malattie legate all'acqua del Centers for Disease Control and Prevention (CDC).Parole chiave: ambienti ricreativi acquatici artificiali, rischio di infezione, epidemie di malattie legate all'acqua, piscine, vasche da idromassaggio.

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Mycobacterium marinuminfections in man

Cited by 101 publications

References 84 publications

Epidemiology and Clinical Significance of Nontuberculous Mycobacteria in Patients Negative for Human Immunodeficiency Virus in Switzerland

Epidemiology and Clinical Significance of Nontuberculous Mycobacteria in Patients Negative for Human Immunodeficiency Virus in Switzerland

A Mycobacterial Gene Involved in Synthesis of an Outer Cell Envelope Lipid Is a Key Factor in Prevention of Phagosome Maturation

The risk of contracting infectious diseases in public swimming pools. A review

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