Infection and tissue engineering in segmental bone defects—a mini review

Nair, Manitha B.; Kretlow, James D.; Mikos, Antonios G.; Kasper, F. Kurtis

doi:10.1016/j.copbio.2011.02.005

Cited by 85 publications

(70 citation statements)

References 48 publications

(53 reference statements)

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“…80 Over 100 000 cases of implant-associated infection and osteomyelitis are reported annually in the United States. 55 On average, 2% to 5% of internal fixation devices become infected 19,74 and may require surgical removal to eliminate the infection. Up to 70% of organisms isolated in prosthetic joint infections are Grampositive agents, including Staphylococcus epidermidis, Staphylococcus aureus, and b-hemolytic streptococci.…”

Section: Implant-related Complicationsmentioning

confidence: 99%

“…Up to 70% of organisms isolated in prosthetic joint infections are Grampositive agents, including Staphylococcus epidermidis, Staphylococcus aureus, and b-hemolytic streptococci. 55,80 Human Bone: Terminology, Organization, and Development…”

Section: Implant-related Complicationsmentioning

confidence: 99%

“…12,48 Athymic nude mice and rats are also commonly used to test osteoinductive and cartilage regenerative potential of allogenic and xenogeneic materials. 16 Rats are used to model bone infection 55 and extraoral surgical approaches. 18 While rodents have limited cortical remodeling or secondary osteon formation, they can model cancellous bone responses in lumbar vertebral bodies and the distal femoral and proximal tibial metaphyses.…”

Section: Model Usesmentioning

confidence: 99%

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Animal Models for Evaluation of Bone Implants and Devices

Wancket

2015

Vet Pathol

167

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Bone implants and devices are a rapidly growing field within biomedical research, and implants have the potential to significantly improve human and animal health. Animal models play a key role in initial product development and are important components of nonclinical data included in applications for regulatory approval. Pathologists are increasingly being asked to evaluate these models at the initial developmental and nonclinical biocompatibility testing stages, and it is important to understand the relative merits and deficiencies of various species when evaluating a new material or device. This article summarizes characteristics of the most commonly used species in studies of bone implant materials, including detailed information about the relevance of a particular model to human bone physiology and pathology. Species reviewed include mice, rats, rabbits, guinea pigs, dogs, sheep, goats, and nonhuman primates. Ultimately, a comprehensive understanding of the benefits and limitations of different model species will aid in rigorously evaluating a novel bone implant material or device.

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Section: Implant-related Complicationsmentioning

confidence: 99%

Section: Implant-related Complicationsmentioning

confidence: 99%

Section: Model Usesmentioning

confidence: 99%

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Animal Models for Evaluation of Bone Implants and Devices

Wancket

2015

Vet Pathol

167

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“…The in situ implantation of a local antibiotic delivery system works to obliterate bacteria in the area as well as to reduce the dead space in the bone (Nair et al, 2011). Its use results in a lower serum antibiotic concentration than that associated with systemic administration, thereby reducing toxicity-related side-effects (Joosten et al, 2005;Samuel et al, 2012) (Table II).…”

Section: Local Antibiotic Therapymentioning

confidence: 99%

“…To supplement oral and systemic antibiotics, local antibiotic delivery has been tried for many years (Gursel et al, 2001;Gitelis, Brebach, 2002;Nair et al, 2011).…”

Section: Local Antibiotic Therapymentioning

confidence: 99%

Osteomyelitis: an overview of antimicrobial therapy

Gomes

Pereira

Bettencourt

2013

Braz. J. Pharm. Sci.

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Osteomyelitis is an inflammatory bone disorder caused by infection, leading to necrosis and destruction of bone. It can affect all ages, involve any bone, become a chronic disease and cause persistent morbidity. Treatment of osteomyelitis is challenging particularly when complex multiresistant bacterial biofilm has already been established. Bacteria in biofilm persist in a low metabolic phase, causing persistent infection due to increased resistance to antibiotics. Staphylococcus aureus and Staphylococcus epidermidis are the most common causative organism responsible for more than 50% of osteomyelitis cases. Osteomyelitis treatment implies the administration of high doses of antibiotics (AB) by means of endovenous and oral routes and should take a period of at least 6 weeks. Local drug delivery systems, using non-biodegradable (polymethylmethacrylate) or biodegradable and osteoactive materials such as calcium orthophosphates bone cements, have been shown to be promising alternatives for the treatment of osteomyelitis. These systems allow the local delivery of AB in situ with bactericidal concentrations for long periods of time and without the toxicity associated with other means of administration. This review examines the most recent literature evidence on the causes, pathogeneses and pharmacological treatment of osteomyelitis. A osteomielite é um processo inflamatório do tecido ósseo, de origem infecciosa, que resulta em destruição inflamatória, necrose e formação de novo osso. Pode aparecer em qualquer idade, afetar qualquer osso e tornar-se uma doença crônica com morbidade persistente. Apesar dos progressos na quimioterapia infecciosa, o tratamento da osteomielite é caro e difícil, em particular quando associada à presença de biofilmes bacterianos, especialmente de Staphylococcus aureus e Staphylococcus epidermidis. O tratamento da osteomielite inclui a administração de doses elevadas de antibióticos (AB) por via endovenosa e oral, durante um período de pelo menos 6 semanas. Os sistemas de veiculação localizada de fármacos, utilizando materiais não biodegradáveis (polimetilmetacrilato) ou biodegradáveis e osteoativos como os cimentos ósseos de ortofosfatos de cálcio e vidro bioativo, surgiram como uma alternativa promissora para o tratamento da osteomielite. Estes sistemas permitem a veiculação de AB in situ com concentrações bactericidas por longos períodos de tempo e sem a toxicidade associada às outras vias de administração. O presente trabalho propõe uma revisão da literatura relativa às causas, à patogenia e ao tratamento farmacológico da osteomielite. A metodologia do estudo da revisão consistiu numa pesquisa bibliográfica, nas bases de dados Google Scholar, Science Direct, Pubmed, Springer link, B-on. Foram revistos e analisados diversos artigos publicados desde o ano de 1979.Unitermos: Osteomielite/tratamento farmacológico. Osteomielite/terapia antimicrobial. Staphylococcus aureus/presença/osteomielite. Antibióticos/uso/tratamento da osteomielite.

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Recent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering

Xue

Yan

Deng

et al. 2021

Adv Funct Materials

297

180

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Bone related diseases have caused serious threats to human health owing to their complexity and specificity. Fortunately, owing to the unique 3D network structure with high aqueous content and functional properties, emerging hydrogels are regarded as one of the most promising candidates for bone tissue engineering, such as repairing cartilage injury, skull defect, and arthritis. Herein, various design strategies and synthesis methods (e.g., 3D‐printing technology and nanoparticle composite strategy) are introduced to prepare implanted hydrogel scaffolds with tunable mechanical strength, favorable biocompatibility, and excellent bioactivity for applying in bone regeneration. Injectable hydrogels based on biocompatible materials (e.g., collagen, hyaluronic acid, chitosan, polyethylene glycol, etc.) possess many advantages in minimally invasive surgery, including adjustable physicochemical properties, filling irregular shapes of defect sites, and on‐demand release drugs or growth factors in response to different stimuli (e.g., pH, temperature, redox, enzyme, light, magnetic, etc.). In addition, drug delivery systems based on micro/nanogels are discussed, and its numerous promising designs used in the application of bone diseases (e.g., rheumatoid arthritis, osteoarthritis, cartilage defect) are also briefed in this review. Particularly, several key factors of hydrogel scaffolds (e.g., mechanical property, pore size, and release behavior of active factors) that can induce bone tissue regeneration are also summarized in this review. It is anticipated that advanced approaches and innovative ideas of bioactive hydrogels will be exploited in the clinical field and increase the life quality of patients with the bone injury.

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Infection and tissue engineering in segmental bone defects—a mini review

Cited by 85 publications

References 48 publications

Animal Models for Evaluation of Bone Implants and Devices

Animal Models for Evaluation of Bone Implants and Devices

Osteomyelitis: an overview of antimicrobial therapy

Recent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering

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