Animal Models for Evaluation of Bone Implants and Devices

Wancket, Lyn M.

doi:10.1177/0300985815593124

Cited by 164 publications

(72 citation statements)

References 67 publications

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“…Sheep and goat experimental models have increased during the last years due to relatively vertical alignment of the cervical vertebrae, which provides similar axial compression and rotation forces to the human spine. However, the main drawbacks are that sheep cortical bone remains predominant at 7-9 years of age, it undergoes seasonal bone loss and sheep and goats have more dense and stronger bones when compared to humans bone [29].…”

Section: Discussionmentioning

confidence: 99%

The Role of Strontium Enriched Hydroxyapatite and Tricalcium Phosphate Biomaterials in Osteoporotic Bone Regeneration

et al. 2019

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Background: Strontium (Sr) enriched biomaterials have been used to improve bone regeneration in vivo. However, most studies provide only two experimental groups. The aim of our study was to compare eleven different bone sample groups from osteoporotic and healthy rabbits’ femoral neck, as it is the most frequent osteoporotic fracture in humans. Methods: Osteoporotic bone defects were filled with hydroxyapatite 30% (HA) and tricalcium phosphate 70% (TCP), 5% Sr-enriched HA30/TCP70, HA70/TCP30, or Sr-HA70/TCP30 granules and were compared with intact leg, sham surgery and healthy non-operated bone. Expression of osteoprotegerin (OPG), nuclear factor kappa beta 105 (NFkB-105), osteocalcin (OC), bone morphogenetic protein 2/4 (BMP-2/4), collagen I (Col-1α), matrix metalloproteinase 2 (MMP-2), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2), interleukin 1 (IL-1) and interleukin 10 (IL-10) was analyzed by histomorphometry and immunohistochemistry. Results: Our study showed that Sr-HA70/TCP30 induced higher expression of all above-mentioned factors compared to intact leg and even higher expression of OC, MMP-2 and NFkB-105 compared to Sr-HA30/TCP70. HA70/TCP30 induced higher level of NFkB-105 and IL-1 compared to HA30/TCP70. Conclusion: Sr-enriched biomaterials improved bone regeneration at molecular level in severe osteoporosis and induced activity of the factors was higher than after pure ceramic, sham or even healthy rabbits.

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Section: Discussionmentioning

confidence: 99%

The Role of Strontium Enriched Hydroxyapatite and Tricalcium Phosphate Biomaterials in Osteoporotic Bone Regeneration

et al. 2019

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“…Most of these animal models were designed to observe the degradation pattern of Mg‐based implants and the response of peri‐implant bone tissues 42,78,79. Therefore, they do not simulate clinical scenarios, or validate potential clinical applications with regards to assessment of bioefficacy of the Mg‐based implants, leading to lack of information on design input as well as output to meet regulatory requirement 80. Herein, we summarize the representative animal models to target at clinical indications by using Mg‐based orthopedic implants for both biosafety and bioefficacy evaluation ( Figures and ).…”

Section: Animal Models For Studying Mg‐based Orthopedic Implantsmentioning

confidence: 99%

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

et al. 2020

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Biodegradable Mg‐based metals may be promising orthopedic implants for treating challenging bone diseases, attributed to their desirable mechanical and osteopromotive properties. This Review summarizes the current status and future research trends for Mg‐based orthopedic implants. First, the properties between Mg‐based implants and traditional orthopedic implants are compared on the following aspects: in vitro and in vivo degradation mechanisms of Mg‐based implants, peri‐implant bone responses, the fate of the degradation products, and the cellular and molecular mechanisms underlying the beneficial effects of Mg ions on osteogenesis. Then, the preclinical studies conducted at the low weight bearing sites of animals are introduced. The innovative strategies (for example, via designing Mg‐containing hybrid systems) are discussed to address the limitations of Mg‐based metals prior to their clinical applications at weight‐bearing sites. Finally, the available clinical studies are summarized and the challenges and perspectives of Mg‐based orthopedic implants are discussed. Taken together, the progress made on the development of Mg‐based implants in basic, translational, and clinical research has laid down a foundation for developing a new era in the treatment of challenging and prevalent bone diseases.

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“…97, 98 Although non-human primates offer the most similarity to human bone with respect to anatomy and physiology, mini-pigs are more widely used because of less critical ethical issues and low purchase and maintenance costs, in addition to easy handling. Unlike pigs, dogs (the “canine model”) with stand repetitive blood sampling during PRP preparation, and their mandibles are large enough to receive commercial implants.…”

Section: Implications For Future Studiesmentioning

confidence: 99%

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

et al. 2017

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Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma (PRP) therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field. Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and (pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed.

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Animal Models for Evaluation of Bone Implants and Devices

Cited by 164 publications

References 67 publications

The Role of Strontium Enriched Hydroxyapatite and Tricalcium Phosphate Biomaterials in Osteoporotic Bone Regeneration

The Role of Strontium Enriched Hydroxyapatite and Tricalcium Phosphate Biomaterials in Osteoporotic Bone Regeneration

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

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