Infected Aneurysm Caused by <i>Desulfovibrio desulfuricans</i> Infection

Fujihara, Tatsuya; Kimura, Keigo; Matsuo, Hiroo; Sada, Ryuichi; Hamaguchi, Shigeto; Yamamoto, Go; Yamakura, Takuya; Kutsuna, Satoshi

doi:10.3201/eid2908.230403

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…A prior investigation revealed that Desulfocibrio desulfuricans could contribute to aneurysm infections ( Fujihara et al, 2023 ). Additionally, another study noted that the order Desulfovibrionales and the family Desulfovibrionaceae were linked to an increased risk of chronic obstructive pulmonary disease ( Wei et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Casual effects of gut microbiota on risk of infections: a two-sample Mendelian randomization study

Lyu,

Ma,

Bai

et al. 2023

Front. Microbiol.

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BackgroundThe correlation between gut microbiota and infections has garnered significant attention in previous studies; nevertheless, our understanding of the causal relationships and mechanisms between specific microbial species and infections remains limited.MethodsThis study aimed to employ Mendelian randomization (MR) using single-nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) data of European ancestry to explore the genetic-level relationships between distinct types of gut microbiota and susceptibility to infections. Our analysis encompassed three prevalent infections: intestinal infections, pneumonia, and urinary tract infections, while concurrently examining various types of gut microbiota.ResultsWe identified 18 protective gut microbiotas alongside 13 associated with increased infection risk. Particularly noteworthy are certain microbial communities capable of producing butyrate, such as the Ruminococcaceae and Lachnospiraceae families, which exhibited both favorable and unfavorable effects. Additionally, we observed a few certain communities linked to infection susceptibility, including ErysipelotrichaceaeUCG003 (OR = 0.13, 95% CI: 0.054–0.33, p = 1.24E-05), Collinsella (OR = 3.25, 95% CI: 2.00–5.27, p = 1.87E-06), and NB1n (OR = 1.24, 95% CI: 1.09–1.40, p = 1.12E-03).ConclusionThis study reveals complex relationships between gut microbiota and various infections. Our findings could potentially offer new avenues for exploring prevention and treatment strategies for infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Casual effects of gut microbiota on risk of infections: a two-sample Mendelian randomization study

Lyu,

Ma,

Bai

et al. 2023

Front. Microbiol.

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Bacteremia caused by Desulfovibrio desulfuricans with the intestinal tract as the portal of entry: two case reports and a literature review

Yamaizumi,

Kyotani,

Kenzaka

2024

BMC Infect Dis

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Background Desulfovibrio desulfuricans (D. desulfuricans), a commensal anaerobic gram-negative rod endemic to the soil environment and human gastrointestinal tract, rarely causes bloodstream infections. We report two rare cases of bacteremia caused by D. desulfuricans in which the intestinal tract was the portal of entry. In addition, we summarize findings on D. desulfuricans. Case presentation Case 1: A 51-year-old man presented to the emergency department with the chief complaints of fever and right lower abdominal pain. He was admitted to the hospital with ascending colonic diverticulitis and received empirical antibacterial therapy with piperacillin/tazobactam. Blood culture revealed D. desulfuricans. The patient was discharged after 2 weeks of antimicrobial therapy. Case 2: A 95-year-old woman presented to our hospital with a chief complaint of fever. Owing to an elevated inflammatory response and pyuria, the patient was diagnosed with pyelonephritis and treated with ceftriaxone. Klebsiella pneumoniae was detected in her urine culture, while D. desulfuricans was detected in her blood culture. The patient was then treated with ampicillin/sulbactam for 14 days. The fecal occult blood test result was positive, suggesting a colonic mucosal lesion, such as a malignant tumor, may have been the portal of entry for D. desulfuricans bacteremia. Previous literature reviews indicate that D. desulfuricans bacteremia often results from liver or renal abscesses, intestinal lesions, among others, serving as the portal of entry. Although no specific underlying disease has been reported, it is more common in the older population. We encountered two cases of D. desulfuricans bacteremia and combined them with 15 cases from previous studies to explore the characteristics of the disease. The proportion of patients aged $$\:\ge\:$$60 years was 73.7%; overall, 73.7% had gastrointestinal complications, and 63.2% had abdominal symptoms at the time of presentation. Conclusions We encountered two rare cases of D. desulfurican bacteremia. This type of bacteremia is more common in elderly people over 60 years of age and is often associated with hepatobiliary and gastrointestinal diseases.

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Infected Aneurysm Caused by Desulfovibrio desulfuricans Infection

Cited by 2 publications

References 7 publications

Casual effects of gut microbiota on risk of infections: a two-sample Mendelian randomization study

Casual effects of gut microbiota on risk of infections: a two-sample Mendelian randomization study

Bacteremia caused by Desulfovibrio desulfuricans with the intestinal tract as the portal of entry: two case reports and a literature review

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