In CRC, the methylation status of multiple promoters can be predicted through knowledge of BRAF and, to a lesser extent, KRAS activating mutations, indicating that these mutations are closely associated with different patterns of DNA hypermethylation. These changes may be important events in colorectal tumorigenesis.

Factors associated with calcification of the abdominal aorta indue to the numerous factors that can accelerate arteriohemodialysis patients.sclerosis in HD patients that do not exist in healthy Background. Cardiovascular and cerebrovascular injury individuals. We have semiquantitatively evaluated the caused by arteriosclerosis has been the major cause of the death calcification of the abdominal aorta using an aortic calciin hemodialysis (HD) patients. We quantitatively analyzed and fication index (ACI) [3] and correlated this index with evaluated the severity of abdominal aortic calcification in HD patients in comparison to risk factors for arteriosclerosis. risk factors for arteriosclerosis in HD patients. This study Methods. One hundred thirty-seven HD patients were exintroduces an alternative method to the ACI to quantiamined. Using image analysis software, areas of the calcified tate calcification on simple abdominal computerized toabdominal aorta were quantitatively analyzed on plain compumography scans in order to better clarify arteriosclerotic terized tomography images. Other factors such as blood presrisk factors in HD patients.sure (BP), lipid levels, and calcium (Ca) ϫ phosphorus (Pi) value were also analyzed.Results. Patients with a higher one-year average of systolic BP showed a higher severity of abdominal aortic calcification. METHODSThat is, the severity of abdominal aortic calcification in patients Subjectswith a one-year systolic BP average above 160 mm Hg was 31.5 Ϯ 13.6%, and this severity was significantly higher than We examined 137 HD patients (70 male and 67 fethat in patients with a one-year systolic BP average of less than male). This average age was 59.7 Ϯ 11.9 years, and they 120 mm Hg (8.0 Ϯ 7.7%, P Ͻ 0.01). The severity of abdominal

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High ACAI was clearly correlated with mortality rate in HD patients, particularly cardiovascular mortality rate. ACAI was a useful long-term prognostic indicator in HD patients.