Infección por el virus del papiloma humano y su correlación con situaciones ginecológicas u obstétricas de relevancia clínica: estudio transversal

López-Hernández, Daniel; Beltrán-Lagunes, Luis; Brito-Aranda, Leticia; López-Hernández, María de la Luz

doi:10.1016/j.medcli.2016.04.018

Cited by 5 publications

(2 citation statements)

References 26 publications

(34 reference statements)

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“…[5]. Не обнаружено влияние паритета на частоту ВПЧ, однако некоторые исследователи отмечают, что паритет имеет обратную связь с папилломавирусной инфекцией [6]. Выявлено, что носительство ВПЧ сопровождается значимо большей частотой воспалительных ЗШМ (80,2% (69/86) против 28% (21/75) среди неинфицированных женщин, р < 0,0001).…”

Section: Discussionunclassified

Disorders of the Cervix and Characteristics of Colposcopy in Pregnant Women

Bebneva¹,

Dikke²,

Moscow³

et al. 2020

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Study Objective: To determine the frequency of disorders of the cervix and identify characteristics of colposcopy specific to pregnant women infected with the human papillomavirus (HPV). Study Design: This was an open-label, non-interventional, comparative, cohort clinical study. Materials and Methods: Three hundred and thirty pregnant women participated in the study. They were divided into four groups: Group I (n = 73) was made up of women without any disorders of the cervix and with a negative test for human papillomavirus (HPV); Group II (n = 75) consisted of women with disorders of the cervix who did not have HPV; Group III (n = 96) comprised those who did not have disorders of the cervix, but had HPV; and Group IV (n = 86) consisted of patients with disorders of the cervix and HPV. Examinations performed included HPV testing with serotyping, cervical cytology (Pap smear), and colposcopy. Study Results: HPV was detected in 55.2% of the patients (182/330), 44.5% of whom (81/182) had types 16/18 HPV. The prevalence of grades I and II disorders of the cervix (mild and moderate) in women who had HPV as well as disorders of the cervix was 17.5% (15/86) according to colposcopy data and 9.3% (8/86) detected by cytology (р = 0.06). The total frequency of these disorders, irrespective of HPV status, was 9.3% (15/161) and 5.6% (9/161), respectively (р = 0.29). Interpretation of the colposcopy data in pregnant women was difficult in some cases due to changes in the cervix, which explains the 3.7% discrepancy between colposcopy and cytology in detecting disorders of the cervix. Conclusion: HPV screening may be done first in pregnant women, followed by cytology in HPV-positive patients. Colposcopy may be reserved for women with high-grade squamous intraepithelial lesions to exclude invasive cancer. Keywords: pregnancy, human papillomavirus, disorders of the cervix, risk factors, colposcopy.

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Section: Discussionunclassified

Disorders of the Cervix and Characteristics of Colposcopy in Pregnant Women

Bebneva¹,

Dikke²,

Moscow³

et al. 2020

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“…The predominance of sexual activity starting between the ages of 10 and 15 years (66.1%) reflects another important risk factor for developing the disease. This is a well-established risk caused by the potential for harm to the as-yet immature cervix, which can be left more susceptible to sexually transmitted infections, and thereby, to infection by HPV [ 15 – 26 – 27 – 28 ]. Early initiation of sexual activity is particularly associated with an increase in the risk of infection by genotype 16 of the virus [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Screening for cervical cancer in imprisoned women in Brazil

Silva

Souza

et al. 2017

PLoS ONE

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Context and objectiveIncarcerated women are more vulnerable to developing cervical cancer than women in general; therefore, screening and intervention programs must be included in their healthcare provision. We therefore aimed to investigate the state of cervical cancer screening for imprisoned women in Mato Grosso do Sul, and to analyze the interventions geared toward the control of cervical cancer.Materials and methodsThis was a cross-sectional study with analysis of primary and secondary data. Interviews were held with 510 women in seven prisons in the Brazilian state of Mato Grosso do Sul. The data for 352 medical records were analyzed statistically with the significance level set at 5%. Associations were assessed by the chi-squared test, adjusted by the Bonferroni correction.ResultsMost female prisoners had limited education, used tobacco, and had key risk factors for the development of cervical cancer. Half of the women interviewed (n = 255) stated that they had received a Papanicolaou (Pap) test in prison, but 134 (52.5%) of these did not know the result. Of those who had not received a Pap test, 149 (58.4%) stated that this was because of a lack of opportunity. There was no information regarding the provision of Pap tests or subsequent treatment in the medical records of 211 (59.9%) women. No protocols were in place for the provision of Pap tests in prison. There were statistical differences between prisons in terms of test frequency, the information provided to women, and how information was recorded in medical records.ConclusionThe screening of cervical cancer in prisons is neither systematic nor regular, and the results are not communicated to women in a significant number of cases. It is necessary to organize health services within the prison environment, ensuring that tests are done and that there is investigation for human papillomavirus. This could increase the diagnosis of cervical cancer at less advanced stages of the disease.

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Association Between Maternal Human Papillomavirus Infection and Adverse Pregnancy Outcomes: Systematic Review and Meta-Analysis

Niyibizi

Zanré

Mayrand

et al. 2020

The Journal of Infectious Diseases

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Background Experimental studies provide evidence of the harmful effect of human papillomavirus (HPV) infection on pregnancy, but observational studies are inconclusive. We systematically assessed the association between HPV and adverse pregnancy outcomes. Methods We searched electronic databases up to December 1, 2019. We included observational studies on the association between HPV and adverse pregnancy outcomes. We conducted a random-effect meta-analysis for each outcome and assessed heterogeneity between studies. Results From 3034 citations, we included 38 studies and quantitatively synthesized 36 studies. Human papillomavirus was significantly associated with preterm birth (age-adjusted odds ratio [aOR], 1.50; 95% confidence interval [CI], 1.19–1.88), preterm premature rupture of membranes (aOR, 1.96; 95% CI, 1.11–3.45), premature rupture of membranes (aOR, 1.42; 95% CI, 1.08–1.86), intrauterine growth restriction (aOR, 1.17; 95% CI, 1.01–1.37), low birth weight (aOR, 1.91; 95% CI, 1.33–2.76), and fetal death (aOR, 2.23; 95% CI, 1.14–4.37). No significant association was found for spontaneous abortion (aOR, 1.14; 95% CI, 0.40–3.22) and pregnancy-induced hypertensive disorders (aOR, 1.24; 95% CI, 0.80–1.92). Most of the studies were of moderate or low quality, and substantial between-studies heterogeneity remained unexplained. Conclusions We found a consistent and significant association between HPV and preterm birth and preterm premature rupture of membranes. Human papillomavirus may also be associated with intrauterine growth restriction, low birth weight, and fetal death, but findings are limited by suboptimal control of biases.

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Infección por el virus del papiloma humano y su correlación con situaciones ginecológicas u obstétricas de relevancia clínica: estudio transversal

Cited by 5 publications

References 26 publications

Disorders of the Cervix and Characteristics of Colposcopy in Pregnant Women

Disorders of the Cervix and Characteristics of Colposcopy in Pregnant Women

Screening for cervical cancer in imprisoned women in Brazil

Association Between Maternal Human Papillomavirus Infection and Adverse Pregnancy Outcomes: Systematic Review and Meta-Analysis

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