Inertial lateral migration and self-assembly of particles in bidisperse suspensions in microchannel flows

Gao, Yanfeng; Magaud, Pascale; Lafforgue, Christine; Colin, Stéphane; Baldas, Lucien

doi:10.1007/s10404-019-2262-6

Cited by 28 publications

(26 citation statements)

References 44 publications

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“…This mechanism of hydrodynamic interactions influencing focussing positions appears different to the recent work of Gao et al [16] investigating bidisperse mixtures in square straight channels, where the larger particles occupy the four main focussing positions and the smaller particles thus remain on an annulus close to the channel wall.…”

Section: Discussioncontrasting

confidence: 87%

“…Capture here does not imply physical contact; it is rather associated with the phenomenon of a small particle being "hijacked" by a larger particle, deviating the small particle from the equilibrium position it would have in a pure population. The formation of trains with evenly distributed particles in inertial focussing devices has been reported previously [16]. Lee et al [19] proposed that inter-particle spacing is a consequence of particle-induced convection.…”

Section: Discussionmentioning

confidence: 74%

“…Particle interactions are known to impact on behaviour within inertial focussing systems. For example, the formation of trains with evenly distributed particles in inertial focussing devices has been reported previously [16,18]. Lee et al proposed that inter-particle spacing is a consequence of particle-induced convection [19].…”

Section: Introductionmentioning

confidence: 97%

“…In order to better understand particle interactions, Gao et al [16] recently explored the effect of bidisperse suspensions on inertial focussing behaviour within straight square channels, reporting that the inertial focussing positions were modified in comparison with performance in monodisperse conditions. A conference paper by the same group revealed that smaller particles are more impacted than larger particles [17].…”

Section: Introductionmentioning

confidence: 99%

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Limitation of spiral microchannels for particle separation in heterogeneous mixtures: Impact of particles’ size and deformability

Guzniczak¹,

Bridle²,

Jimenez

2020

Biomicrofluidics

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Spiral microchannels have shown promising results for separation applications. Hydrodynamic particle-particle interactions are a known factor strongly influencing focussing behaviours in inertial devices, with recent work highlighting how the performance of bidisperse mixtures is altered when compared with pure components, in square channels. This phenomenon has not been previously investigated in detail for spiral channels. Here, we demonstrate that, in spiral channels, both the proportion and deformability of larger particles (13 µm diameter) impact upon the recovery (up to 47% decrease) of small rigid particles (4 µm). The effect, observed at low concentrations (volume fraction <0.0012), is attributed to the hydrodynamic capture of beads by larger cells. These changes in particles focussing behaviour directly impede the efficiency of the separation-diverting beads from locations expected from measurements with pure populations to co-collection with larger cells-and could hamper deployment of the technology for certain applications. Similar focussing behaviour alterations were noted when working with purification of stem cell end products.

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Limitation of spiral microchannels for particle separation in heterogeneous mixtures: Impact of particles’ size and deformability

Guzniczak¹,

Bridle²,

Jimenez

2020

Biomicrofluidics

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“…particle-particle interactions. 41,42 This experiment provides proof of concept for deformability-based cell separation in spiral microchannels.…”

Section: Lab On a Chip Papermentioning

confidence: 81%

Deformability-induced lift force in spiral microchannels for cell separation

et al. 2020

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Microfluidics‐Based Urine Biopsy for Cancer Diagnosis: Recent Advances and Future Trends

2022

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Urine biopsy, allowing for the detection, analysis and monitoring of numerous cancer-associated urinary biomarkers to provide insights into cancer occurrence, progression and metastasis, has emerged as an attractive liquid biopsy strategy with enormous advantages over traditional tissue biopsy, such as non-invasiveness, large sample volume, and simple sampling operation. Microfluidics enables precise manipulation of fluids in a tiny chip and exhibits outstanding performance in urine biopsy owing to its minimization, low cost, high integration, high throughput and low sample consumption. Herein, we review recent advances in microfluidic techniques employed in urine biopsy for cancer detection. After briefly summarizing the major urinary biomarkers used for cancer diagnosis, we provide an overview of the typical microfluidic techniques utilized to develop urine biopsy devices. Some prospects along with the major challenges to be addressed for the future of microfluidicbased urine biopsy are also discussed.

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Inertial lateral migration and self-assembly of particles in bidisperse suspensions in microchannel flows

Cited by 28 publications

References 44 publications

Limitation of spiral microchannels for particle separation in heterogeneous mixtures: Impact of particles’ size and deformability

Limitation of spiral microchannels for particle separation in heterogeneous mixtures: Impact of particles’ size and deformability

Deformability-induced lift force in spiral microchannels for cell separation

Microfluidics‐Based Urine Biopsy for Cancer Diagnosis: Recent Advances and Future Trends

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