Microfluidics‐Based Urine Biopsy for Cancer Diagnosis: Recent Advances and Future Trends

Wang, Yanping; Gao, Yanfeng; Song, Yujun

doi:10.1002/cmdc.202200422

Cited by 5 publications

(2 citation statements)

References 180 publications

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“…In addition to infection detection, a bladder-on-a-chip system has been used for noninvasive diagnostic purposes. Wang et al developed a protein microarray chip to capture bladder cancer cells and biomarkers from urine samples [152]. Similarly, Lin et al were able to have a quantitative measurement of biomarker concentration using a bead-based enzyme-linked immunosorbent assay [153].…”

Section: Bladder-on-a-chipmentioning

confidence: 99%

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications in Disease Diagnostics

Farhang Doost,

Srivastava

2024

Preprint

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Organ-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell culture due to various limitations of in vivo testing. Unfortunately, in vitro cell culture fails to provide an accurate microenvironment, and in vivo cell culture is expensive and has historically been a source of ethical controversy. OOC aims to overcome these shortcomings and provide the best of both in vivo and in vitro cell culture research. The key component of the OOC design is utilizing microfluidics to ensure a stable concentration gradient, dynamic mechanical stress modeling, and accurate reconstruction of a cellular microenvironment. OOC also has the advantage of complete observation and control of the system, which is impossible to recreate in in vivo research. Multiple throughputs, channels, membranes, and chambers are constructed in a polydimethylsiloxane (PDMS) array to simulate various organs on a chip. Various experiments can be performed utilizing OOC technology, including drug delivery research and toxicology. Current technological expansions involve multiple organ microenvironments on a single chip, allowing for studying inter-tissue interactions. Other developments in the OOC technology include finding a more suitable material as a replacement for PDMS and minimizing artefactual error and non-translatable differences.

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Section: Bladder-on-a-chipmentioning

confidence: 99%

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications in Disease Diagnostics

Farhang Doost,

Srivastava

2024

Preprint

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“…Their results showed that the DLD particle size-based sorting method could provide a rich and diverse population of SSCs. DLD technology also shows excellent potential in isolating circulating tumor cells; CTCs are separated from the blood or urine [11,12] by a DLD chip and are diagnosed with related cancers. Tang, H. et al [13] used a new design method of extension optimization to shorten the device and flexibly manipulate the cell motion path for efficient sorting of the circulating tumor cells (CTCs).…”

Section: Introductionmentioning

confidence: 99%

A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD Arrays

et al. 2023

Fluids

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Erythrocyte enrichment is needed for blood disease diagnosis and research. DLD arrays with an I-shaped pillar (I-pillar) sort erythrocytes in a unique, accurate, and low-reagent method. However, the existing I-shaped pillar DLD arrays for erythrocyte sorting have the drawbacks of higher flow resistance and more challenging fabrication. A two-dimensional erythrocyte simulation model and the arbitrary Lagrangian–Euler equations at the cell–fluid boundary were built based on the fluid–solid coupling method to investigate the influencing factors of the erythrocyte flow path in an I-pillar DLD array and find its optimization method. Three different sizes of I-pillars were built and multiple sets of corresponding arrays were constructed, followed by finite element simulations to separately investigate the effects of these arrays on the induction of erythrocyte motion paths. This work demonstrates the motion paths of erythrocyte models in a series of I-pillar arrays with different design parameters, aiming to summarize the variation modes of erythrocyte motion paths, which in turn provides some reference for designing and optimizing the pillar size and array arrangement methods for I-pillar array DLD chips.

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Magnetic quantum dots barcodes using Fe3O4/TiO2 with weak spectral absorption in the visible region for high-sensitivity multiplex detection of tumor markers

Zhang

Tang

Ding

2023

Biosensors and Bioelectronics

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Microfluidics‐Based Urine Biopsy for Cancer Diagnosis: Recent Advances and Future Trends

Cited by 5 publications

References 180 publications

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications in Disease Diagnostics

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications in Disease Diagnostics

A Numerical Study on the Erythrocyte Flow Path in I-Shaped Pillar DLD Arrays

Magnetic quantum dots barcodes using Fe3O4/TiO2 with weak spectral absorption in the visible region for high-sensitivity multiplex detection of tumor markers

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