INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia–CORRECTED VERSION

Torralva, Teresa; Roca, M; Gleichgerrcht, Ezequiel; López, Pablo; Manes, Facundo

doi:10.1017/s1355617709990415

Cited by 233 publications

(177 citation statements)

References 38 publications

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“…Although the patients who participated in this study fulfilled criteria for probable bvFTD, as in many other reports [27,28,30,31,32,33,61,62,78,79], a biomarker against Alzheimer's disease is not available, which constitutes a limitation of our work. Future studies should further explore structural correlates of moral judgment in bvFTD patients with biomarker measurements as well as in other variants of frontotemporal dementia.…”

Section: Discussionmentioning

confidence: 95%

“…As in previous reports by our group [29,30,31,32], diagnosis was initially made by a group of experts in bvFTD. Each case was individually reviewed in a multidisciplinary clinical meeting involving cognitive neurologists, psychiatrists, and neuropsychologists.…”

Section: Methodsmentioning

confidence: 99%

“…The general cognitive status of the participants (table 1) was assessed using the Mini-Mental State Examination (MMSE) [35] and the INECO Frontal Screening [31]. …”

Section: Methodsmentioning

confidence: 99%

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Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural Signatures

et al. 2016

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Background: Moral judgment has been proposed to rely on a distributed brain network. This function is impaired in behavioral variant frontotemporal dementia (bvFTD), a condition involving damage to some regions of this network. However, no studies have investigated moral judgment in bvFTD via structural neuroimaging. Methods: We compared the performance of 21 bvFTD patients and 19 controls on a moral judgment task involving scenarios that discriminate between the contributions of intentions and outcomes. Voxel-based morphometry was used to assess (a) the atrophy pattern in bvFTD patients, (b) associations between gray matter (GM) volume and moral judgments, and (c) structural differences between bvFTD subgroups (patients with relatively preserved moral judgment and patients with severer moral judgment impairments). Results: Patients judged attempted harm as more permissible and accidental harm as less permissible than controls. The groups' performance on accidental harm was associated with GM volume in the precuneus. In controls, it was al- so associated with the ventromedial prefrontal cortex (VMPFC). Also, both groups' performance on attempted harm was associated with GM volume in the temporoparietal junction. Patients exhibiting worse performance displayed smaller GM volumes in the precuneus and temporal pole. Conclusions: Results suggest that moral judgment abnormalities in bvFTD are associated with impaired integration of intentions and outcomes, which depends on an extended brain network. In bvFTD, moral judgment seems to critically depend on areas beyond the VMPFC.

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Section: Discussionmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

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Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural Signatures

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“…Caldeira et al (2011), tendo revelado características psicométricas similares à versão original e uma boa consistência interna (alfa de Chronbach=.829), demonstrando ser uma prova neuropsicológica breve, sensível e específica para a deteção da disfunção executiva na patologia neurodegenerativa. A pontuação difere em cada subteste consoante a performance realizada pelo indivíduo avaliado, podendo a pontuação global variar entre um mínimo de 0 e um máximo de 30 pontos (Torralva et al, 2009).…”

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INECO frontal screening: um instrumento para avaliar as funções executivas na depressão

Nunes¹,

Monteiro²,

Lopes

2014

Psicol. clin.

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“…Así, se han propuesto distintos modelos que tienen en común la idea de que este mecanismo permite controlar y regular la conducta a través de diversos procesos cognitivos, siendo necesario establecer unidades manejables (Tirapu-Ustárroz, García-Molina, Luna-Lario, Roig-Rovira, 2008a,b; Tirapu-Ustárroz, Muñoz-Céspedes y Pelegrín-Valero, 2002).…”

Section: El Control Ejecutivounclassified

Procesos de control ejecutivo en la enfermedad de Alzheimer.

García-Viedma

Fernández-Guinea²,

Montes³

2012

analesps

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Resumen: El control ejecutivo (CE) es un mecanismo complejo compuesto por distintos subprocesos y vinculado al funcionamiento del lóbulo frontal. En los últimos años se ha generado una gran cantidad de investigación sobre los déficit de control ejecutivo (CE) en pacientes con enfermedad de Alzheimer (EA). Este análisis resulta de gran interés porque, por una parte, estudios recientes han observado precisamente alteraciones en regiones frontales en estos pacientes, y por otra parte, porque sus manifestaciones clínicas y conductuales en el inicio de la enfermedad están relacionadas con la afectación del CE. En este artículo se revisa detalladamente la evidencia existente sobre la afectación de los subprocesos del CE al inicio de la EA, determinando si habría un deterioro generalizado o disociaciones entre los componentes, así como sus posibles implicaciones básicas y aplicadas. Palabras clave: Alzheimer; control ejecutivo; neuropsicología; red ejecutiva.Title: Executive control processes in Alzheimer's disease. Abstract: It has been recently proposed that executive control (EC) is composed by different subprocesses. In recent times, EC deficits in Alzheimer's disease patients (AD) have been widely investigated. This analysis is very interesting because, on the one hand, recent studies have observed frontal lobe alterations on these demented patients, and on the other hand, Alzheimer's disease clinical and behavioural manifestations could be explained by the involvement of EC. This paper discusses in detail the possible involvement of EC subprocesses at the beginning of AD, determining if there would be a widespread decline or dissociations between components and their basic and clinical implications. Keywords: Alzheimer; executive control; neuropsychology; executive network. IntroducciónEl control ejecutivo (CE) es un mecanismo complejo que implica varias operaciones relacionadas con el control y la regulación de la conducta. Este mecanismo depende de un sistema neuronal distribuido en el que destaca el papel del córtex prefrontal (CPF), el cual tiene importantes conexiones córtico-corticales (con córtex asociativo y paralímbico) y córtico-subcorticales (principalmente con los ganglios basales, el tálamo y el hipocampo) (Cummings, 1993; Faglioni, 1999;Fuster, 1997;Karatekin, Lazareff y Asarnow, 2000;Quintana y Fuster, 1999). De esta forma, el correcto funcionamiento del CE depende de regiones corticales, tanto anteriores como posteriores, y subcorticales.El CE ha sido explorado extensamente en diversas patologías, como por ejemplo en tumores cerebrales, traumatismos craneoencefálicos, enfermedades cerebrovasculares, la enfermedad de Parkinson, la esclerosis múltiple, etc. (Fontaine, Azouvi, Remy, Bussel, y Samson, 1999; Brown y Marsden, 1998; Foong, Rozewicz, Quaghebeur, Davie y Kartsounis, 1997; Leskela, Heitanen, Kalska, Ylikoski y Pdijasvaara, 1999). Del mismo modo, el análisis del funcionamiento ejecutivo en la enfermedad de Alzheimer (EA) ha sido objeto de un gran interés. Diversos estudios muestran que esto...

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INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia–CORRECTED VERSION

Cited by 233 publications

References 38 publications

Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural Signatures

Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural Signatures

INECO frontal screening: um instrumento para avaliar as funções executivas na depressão

Procesos de control ejecutivo en la enfermedad de Alzheimer.

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