Industrial Biotechnology—An Industry at an Inflection Point

Danielson, Nathan; McKay, Sarah; Bloom, P.; Dunn, Jennifer B.; Jakel, Neal; Bauer, Timothy A.; Hannon, John; Jewett, Michael C.; Shanks, Brent H.

doi:10.1089/ind.2020.29230.nda

Cited by 8 publications

(10 citation statements)

References 25 publications

(25 reference statements)

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“…In general, about 70-75% of the total production cost is related to raw materials. Therefore, fully understanding the dynamics of raw material supply and demand and its potential impact on market prices is very important for developers of biotechnologies [15].…”

Section: Industrial Production By Biotechnologymentioning

confidence: 99%

“…One of the strengths of white biotechnology is that it can synthesize a wide range of chemical products. The chemical industry has developed primarily from hydrocarbon raw materials, and their products have been commercialized and their manufacturing technology has matured [15,16]. The challenge of industrial biotechnology, meanwhile, is to produce promising chemical products for commercialization [15,17].…”

Section: Industrial Production By Biotechnologymentioning

confidence: 99%

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White biotechnology and the production of bio-products

Kordi

Salami

Bolouri

et al. 2022

Syst Microbiol and Biomanuf

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White biotechnology uses enzymes and microorganisms to produce value-added chemicals from renewable sources. White biotechnology provides valuable components for the food, pharmaceutical, agricultural sectors as well as other industries. Metabolic diversity in fungi, yeast, and bacteria can be exploited to produce food additives and other industrial products. This is an interesting topic for those interested in screening and metabolic testing of microorganisms, industrial biotechnology, fermentation technology, and the biological products research community. The use of microbial-derived compounds has a long history in the food industry, and compounds such as flavorings, essential amino acids, poly-unsaturated fatty acids, organic acids, gelling, etc. can be obtained from microbial sources. Also, the role of microbes in human health and wellbeing cannot be ignored. Microbes produce primary metabolites such as vitamins, nucleotides, and amino acids, as well as secondary metabolites. These secondary metabolites are used to make many drugs. In agriculture, microbes are also used to make fertilizers and biological pesticides. This paper reviews the types of bio-products obtained through biotechnology and the barriers and challenges of white biotechnology.

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Section: Industrial Production By Biotechnologymentioning

confidence: 99%

Section: Industrial Production By Biotechnologymentioning

confidence: 99%

White biotechnology and the production of bio-products

Kordi

Salami

Bolouri

et al. 2022

Syst Microbiol and Biomanuf

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“…Table 1. Lignocellulose composition of raw and LX-pretreated RS and DCS (FS = feedstock, as = acid soluble, ais = acid insoluble, LX-C = LX-Cellulose, LX-L = LX-Lignin) 1 . While 38.0% of cellulose could be determined in the RS feedstock, 60.1% glucan was present in the corresponding LX-Cellulose from RS.…”

Section: Analytics Of Raw and Lx-pretreated Feedstocksmentioning

confidence: 99%

“…Biorefineries are evolving, since industry and consumer demand for materials made from renewable resources is continually on the rise. Coupled with sufficient political incentives, the bioeconomy is expected to be thriving in the next few decades [ 1 , 2 ]. Similar to the vast expansion of the petrochemical product range, biorefineries are anticipated to diversify their production lines and establish sustainable platform technologies.…”

Section: Introductionmentioning

confidence: 99%

“…Similar to the vast expansion of the petrochemical product range, biorefineries are anticipated to diversify their production lines and establish sustainable platform technologies. To meet this objective, the need for stronger connections between feedstock, conversion technologies and end usage of the obtained products has been emphasized [ 1 ]. Whilst starch or sucrose-containing feedstocks (e.g., corn, sugar cane) are the main sources for industrial biotechnology at present, alternative feedstocks are increasingly coming into focus of research and innovative enterprises [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Biorefinery Concept Employing Bacillus coagulans: LX-Lignin and L-(+)-Lactic Acid from Lignocellulose

Schroedter

Streffer²,

Streffer³

et al. 2021

Microorganisms

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A new biorefinery concept is proposed that integrates the novel LX-Pretreatment with the fermentative production of L-(+)-lactic acid. Lignocellulose was chosen as a substrate that does not compete with the provision of food or feed. Furthermore, it contains lignin, a promising new chemical building material which is the largest renewable source for aromatic compounds. Two substrates were investigated: rye straw (RS) as a residue from agriculture, as well as the fibrous digestate of an anaerobic biogas plant operated with energy corn (DCS). Besides the prior production of biogas from energy corn, chemically exploitable LX-Lignin was produced from both sources, creating a product with a low carbohydrate and ash content (90.3% and 88.2% of acid insoluble lignin). Regarding the cellulose fraction of the biomass, enzymatic hydrolysis and fermentation experiments were conducted, comparing a separate (SHF), simultaneous (SSF) and prehydrolyzed simultaneous saccharification and fermentation (PSSF) approach. For this purpose, thermophilic B. coagulans 14-300 was utilized, reaching 38.0 g L−1 LA in 32 h SSF from pretreated RS and 18.3 g L−1 LA in 30 h PSSF from pretreated DCS with optical purities of 99%.

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