“…Herein, the cellular effects of complex 1 , a ternary copper(II) complex containing 4-fluorophenoxyacetic acid hydrazide and 1,10-phenanthroline as ligands was evaluated on prostate cells, and the mutagenic/recombinogenic and anticarcinogenic potential of this compound were recorded in D. melanogaster . In the literature, several studies with copper(II) complexes with N , N -donor ligands ( Table 2 ), such as 1,10-phenanthroline and 2,2-bipyridine, have shown promising antitumor effects [ 10 , 27 , 28 , 29 , 30 , 31 , 32 ] and, in our study, complex 1 was selective for the LNCaP lineage, downregulating Ki-67 and Cyclin D1. In PCa, Ki-67 expression has been related to the Gleason score, lower disease-free survival, tumor invasion into the seminal vesicles, and biochemical recurrence or even death after radical prostatectomy [ 33 ].…”