Induction of hepatic drug metabolizing enzymes by DL-methionine in rats

Kamat, J.P.; Narurkar, L. M.; Narurkar, M. V.

doi:10.1007/bf02716683

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…Specific dietary amino acids also have specific inductive effects on the mixed-function oxidase system, and tryptophan has been claimed to be unique among amino acids in that it increases hepatic protein synthesis, cytochrome P-450 content and various cytochrome P-450-mediated oxygenase activities (Everts and Mostafa 1981), although more recently i.p. injection of DL-methionine to rats has been shown similarly to induce cytochromes P-450 and bs, P-450 reductase, UDPGA-transferase and aminopyrine demethylase activity (Kamat et al 1989). "Albino rats were fed 28 days from weaning on the low protein diet (3-5% casein) or on the normal protein diet (26%).…”

Section: Protein and Sulphur Amino Acidsmentioning

confidence: 96%

Nutritional requirements for detoxication of environmental chemicals

Parke

1991

Food Additives and Contaminants

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The biological defence systems against oxygen radical toxicity and chemical toxicity, and their component enzymes, are described, and the nutritional requirements for biological defence against chemical and oxygen toxicity, including calories, protein, lipids and lipotropes, vitamins and minerals, are reviewed in the context of their contribution to the mechanisms of detoxication. Modulation of the cytochromes P-450, and hence toxicity, by dietary components are considered; the P450I family, induced by food pyrolysis mutagens, and the P450IIE family, induced by alcohol and fasting, contribute substantially to chemical toxicity and carcinogenicity. It is concluded that: (i) the detoxication system of terrestrial fauna has evolved over greater than 300 million years to protect animals from dietary plant toxins; (ii) protection against chemical and oxygen toxicity requires all categories of nutrients; and (iii) the rôle of food and nutrition in detoxication is essential to survival.

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Section: Protein and Sulphur Amino Acidsmentioning

confidence: 96%

Nutritional requirements for detoxication of environmental chemicals

Parke

1991

Food Additives and Contaminants

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“…The results showed that with the drug-loading vehicles, EPO can stay in vivo longer and in this way the therapy effect of EPO will be enhanced definitely. Metabolism of EPO has been proved that in the kidney, liver, heart and neural tissue [18]. Fig.…”

Section: Epo Cures and Metabolize Of Epo Nanoparticles In Vivomentioning

confidence: 99%

“…After 313h the concentration dropped down as show in the curve. The releasing curve can be attributed to two factors: first, the degradation of nanoparticles was the reason for instantaneous increase of spectrum; second, slow penetration of PBS into the shell brought a slowly change in cross-linking density of the polyelectrolyte complexes, leading to a slow releasing of EPO after the abrupt increase of the signal [15][16][17].…”

Section: Epo-loading Nanoparticlesmentioning

confidence: 99%

“…It should prove particularly useful in investigating the effects of altered body metabolism of drugs or endogenous neurochemicals on drug therapeutic efficacy, drug interactions, neurotoxicity, and behavior. Selective induction or inhibition of metabolically active drug metabolizing enzymes in the body may also provide ways to control drug activation in specific brain regions as a novel therapeutic avenue [18].…”

Section: Epo Cures and Metabolize Of Epo Nanoparticles In Vivomentioning

confidence: 99%

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Erythropoietin Nanopariticles: Therapy for Cerebral Ischemic Injury and Metabolize in Kidney

Wang¹,

Hu²,

Zhang³

et al. 2010

Nano BioMed ENG

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Ischemic metabolism in the enterogram is a crucial issue of clinical concern for deep understanding of drug delivery. In this study we use nanochemistry in micelle to produce the nanocarrier of erythropoietin (EPO) and traced the metabolizable process of the EPO carrier in vivo. Nascence Sprague-Dawley rats of 5 days are treated with EPO-loading nanocarriers. Curative effects of the EPO nanocarriers for periventricular leukomalacia (PVL) models are validated by the analysis of pathology and praxiology of the mice. We demonstrate in vivo that EPO nanocarriers can ameliorate drug-induced liquefaction caused by hypoxia. By tracking the metabolism of EPO in liver and kidney, we suggest that nanocarriers effectively prolong the metabolic half-life and clearance time of EPO. HPLC results show that exciting amino acid toxicity was inhibited, since mobilization of late oligodendrocyte can be protected by treatment of EPO vehicles from hypoxia.

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“…It also acts as a lipotropic agent and prevents excess fat build-up in the liver. Low levels of Methionine are known to cause temporary folic acid deficiency by trapping the folate in the liver (Brosnan et al, 2006;Kamat et al, 1989). Antioxidant Vitamins [A,C,E] and Methylsulfonylmethane that support phase I and phase II activities also serve as hepatoprotective agents.…”

Section: Introductionmentioning

confidence: 99%

Effects of DL-Methionine at various doses per se on liver in albino rats: An experimental study

Dass¹,

Goswami²,

Mehta³

2020

Asian J Pharm Pharmacol

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Objective: Oxidative stress and diminished glutathione play critical roles in the pathogenesis of liver disease. Synthesis of glutathione, the most abundant mammalian antioxidant, is regulated at the substrate level by cysteine, which is synthesized from homocysteine via the trans-sulfuration pathway. Hence, the research study was aimed to explore the effects of single oral dose per se DL-Methionine.: Albino rats were separated into Material and Methods three groups for the experimental study. After overnight fasting, the albino rats belonging to Group I Control Group were administered Distilled Water 10 ml/kg orally; Group II Met. 700 mg/kg & Group III Met. 1400 mg/kg were administered DL-Methionine as a single oral dose by intragastric cannula. After 24-hours of post-treatment, serum level was evaluated to demonstrate the per se effects of DL-Methionine on liver. Also, the liver samples from each group were examined for the histopathological study.: The histopathological findings of DL-Methionine per se Results treated rats were compared with the control group. Gross examination revealed near to normal appearance & morphologic changes of liver tissue showed normal morphology and normal hepatic parenchymal cells. We observed that DL-Methionine as a single oral dose of 700 mg/kg and 1400 mg/ kg although caused alteration in levels of liver enzymes the alteration was not statistically significant.: DL-Methionine per se although showed alteration Conclusion in the biochemical parameters, they were not found to be significant so as to be considered as hepatotoxic agent. Also, Methionine is commonly used nutritional, essential amino acid, is preferred in the treatment of Paracetamol poisoning.

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Induction of hepatic drug metabolizing enzymes by DL-methionine in rats

Cited by 5 publications

References 20 publications

Nutritional requirements for detoxication of environmental chemicals

Nutritional requirements for detoxication of environmental chemicals

Erythropoietin Nanopariticles: Therapy for Cerebral Ischemic Injury and Metabolize in Kidney

Effects of DL-Methionine at various doses per se on liver in albino rats: An experimental study

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