Induction of CYP3A by morroniside in rats

Xiong, Shanbai; Li, Jinglai; Zhang, Wenpeng; Wang, Xiaoying; Zhang, Zhenqing

doi:10.1016/j.jphs.2015.02.014

Cited by 6 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hepatic microsomes from SD and SHR (n = 5 per group) were prepared according to our previously reported method (Xiong et al, 2015). The microsomal protein concentrations were determined by using the Lowry method (Lowry et al, 1951).…”

Section: In Vivo Pharmacokinetic Studiesmentioning

confidence: 99%

Simultaneous determination of paeoniflorin from total glucosides of paeony in Sprague–Dawley rats and spontaneously hypertensive rats by high‐performance liquid chromatography–tandem mass spectrometry: in vivo and in vitro studies

Xiong

Wang

2016

Biomedical Chromatography

Self Cite

View full text Add to dashboard Cite

Paeoniflorin is a well-known monoterpene glucoside in the herbal drug that exhibits a number of biological activities. The pharmacokinetic characteristics of paeoniflorin from total glucosides of paeony in spontaneously hypertensive rats (SHR) are still unclear. It is essential to investigate the in vivo and in vitro pharmacokinetic differences of paeoniflorin from total glucosides of paeony in Sprague-Dawley (SD) and SHR. The in vivo pharmacokinetic data were analyzed using DAS 2.0 software and the in vitro metabolic characteristics were measured using rat hepatic microsomes. The concentration of paeoniflorin in biological samples was determined using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry method, which showed good precision and stability. The plasma concentration-time profiles of paeoniflorin following oral administration of total glucosides of paeony showed a single peak and there were significant differences in the mean values of AUC , AUC , CL /F and T between SD and SHR (p < 0.05). The metabolic rate of paeoniflorin from total glucosides of paeony was slower in SHR than in SD rats (p < 0.05). The results might be useful in further applications of paeoniflorin and total glucosides of paeony. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Section: In Vivo Pharmacokinetic Studiesmentioning

confidence: 99%

Simultaneous determination of paeoniflorin from total glucosides of paeony in Sprague–Dawley rats and spontaneously hypertensive rats by high‐performance liquid chromatography–tandem mass spectrometry: in vivo and in vitro studies

Xiong

Wang

2016

Biomedical Chromatography

Self Cite

View full text Add to dashboard Cite

show abstract

“…In particular, morroniside can induce the hepatic expression and activity of CYP3A in rats. 24 In our previous study, PMJHH was reported to inhibit the activity of human hepatic CYP2D6 with an IC 50 value of 280.89 µg/mL, 9 suggesting that PMJHH may increase the plasma concentration of tamsulosin by inhibiting its metabolism. However, only previous reports are not sufficient to conclude whether PMJHH affect the pharmacokinetics of tamsulosin.…”

Section: Discussionmentioning

confidence: 96%

Effects of Palmijihwang-hwan: A Herbal Formula on the Pharmacokinetics of Tamsulosin in Rats

Jin

Jeon

Hwang

et al. 2023

Pharmacognosy Magazine

View full text Add to dashboard Cite

Background Tamsulosin is an α1-adrenoceptor antagonist used to treat lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Palmijihwang-hwan (PMJHH) is a traditional herbal formula for treating prostatic disorders and is often used with tamsulosin for treating LUTS/BPH. The co-administration of herbal medicines and conventional drugs increases the potential for clinically considerable herb−drug interactions. Hence, it is important to evaluate the safety of such combinations of drugs. This study aimed to investigate the influence of PMJHH on the pharmacokinetics of tamsulosin in rats. Materials and Methods We developed and validated a simple and rapid method to determine the plasma levels of tamsulosin in rats using an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) system. After oral administration of tamsulosin (2 mg/kg), either alone or in combination with PMJHH (930 mg/kg), to rats, blood samples were collected at various times and used for pharmacokinetic studies. The pharmacokinetic parameters were analyzed using a non-compartmental model. Results Compared to tamsulosin alone, co-administration of PMJHH had no significant effects on any pharmacokinetic parameters of tamsulosin, including maximal plasma concentration (Cmax), time to Cmax (Tmax), terminal elimination half-life ( t1/2), AUC from time 0 to the last observation (AUC0−t), mean residence from time 0 to infinity (MRT0−∞), apparent oral clearance (Cl/F), and apparent volume of distribution during terminal elimination (Vz/F). Conclusion The pharmacokinetics of tamsulosin were not affected by the co-administration of PMJHH. Our findings, therefore, validate the safety of the combination of tamsulosin and PMJHH commonly used for treating LUTS/BPH.

show abstract

“…Shan Xiong found morroniside could induce the activity, mRNA and protein expression of CYP 3A in rats after pretreatment of morroniside (10, 30, 90 mg/kg) for 7 days. 17 In addition, the plasma protein binding percentages of morroniside were 40.46% to 48.38%, 24.45% to 34.75%, and 22.60% to 27.11% in rats, beagles, and humans, respectively. 18…”

Section: Pharmacokineticsmentioning

confidence: 92%

Pharmacokinetics and Pharmacodynamics of Morroniside: A Review

Lei

Xiong

et al. 2019

Natural Product Communications

Self Cite

View full text Add to dashboard Cite

Morroniside belongs to a group of iridoid glycosides and is the primary active component of Cornus officinalis Sieb. et Zucc. This species is a rich source of iridoid glycosides and has been used as a traditional Chinese medicinal herbs for centuries. In this review, we discuss the pharmacokinetics and pharmacodynamics of morroniside. Morroniside is quickly absorbed and metabolized and is widely distributed throughout the body. It also exerts various pharmacological effects. Numerous pharmacological studies have indicated that morroniside plays a role in protecting the nervous system, treating osteoarthritis, inhibiting platelet aggregation, preventing diabetic angiopathies and renal damage, and reducing bone resorption, among others. Future research need to be conducted in support of the development of morroniside as a potential drug.

show abstract

Induction of CYP3A by morroniside in rats

Cited by 6 publications

References 19 publications

Simultaneous determination of paeoniflorin from total glucosides of paeony in Sprague–Dawley rats and spontaneously hypertensive rats by high‐performance liquid chromatography–tandem mass spectrometry: in vivo and in vitro studies

Simultaneous determination of paeoniflorin from total glucosides of paeony in Sprague–Dawley rats and spontaneously hypertensive rats by high‐performance liquid chromatography–tandem mass spectrometry: in vivo and in vitro studies

Effects of Palmijihwang-hwan: A Herbal Formula on the Pharmacokinetics of Tamsulosin in Rats

Pharmacokinetics and Pharmacodynamics of Morroniside: A Review

Contact Info

Product

Resources

About