Induction of cellular apoptosis in human breast cancer by DLBS1425, aPhaleria macrocarpacompound extract, via down-regulation of PI3-kinase/AKT pathway

Optimizing oil and xanthorrhizol extraction from Curcuma xanthorrhiza Roxb. rhizome by supercritical carbon dioxide

“…The most widely used method is based on organic solvent extraction (Lang and Wai 2001;Tandrasasmita et al 2010Tandrasasmita et al , 2011Tjandrawinata et al 2010). Organic solvent extraction methods have drawbacks such as usage of organic solvent, production of hazardous wastes and few adjustable parameters to control the selectivity of extraction process.…”

A Role for Phaleria Macrocarpa (Scheff) Boerl. Extracts in the Management of Women’s Pathological Conditions: A Research Review

“…Further, it induced pro-apoptotic genes including BAX, Bcl-2-associated death promoter (BAD) and p35 upregulated modulator of apoptosis (PUMA) and consequently induces cellular death signal by caspase-9 activation, promoting poly ADP-ribose polymerase (PARP) cleavage and DNA fragmentation. Our results suggest that DLBS1425 is a potential anticancer agent which targets genes that are involved in both cell survival and apoptosis in MDA-MB-231 breast cancer cells [48].…”

“…It is the leading cause of cancer mortality in developing countries due to the high rate of HPV infection and lack of prevention steps in susceptible women. The most common HPV genotypes found in patients with invasive cervical cancer are 16,18,31,33,35,45,52 and 58. Out of these HPV genotypes, HPV 16 and 18 are classed as high-risk oncogenic types and are most likely to persist and progress from premalignant cervical disease to invasive cancer.…”

“…In our attempts to find a natural remedy for endometriosis, P. macrocarpa which is commonly known as crown of god or mahkota dewa, our study suggested that it was a promising candidate [35,36]. Originated from Papua, Indonesia, P. macrocarpa has been traditionally used by Indonesians to treat different chronic diseases ranging from diabetes, hepatitis to cancer [35][36][37].…”

“…Originated from Papua, Indonesia, P. macrocarpa has been traditionally used by Indonesians to treat different chronic diseases ranging from diabetes, hepatitis to cancer [35][36][37]. However, most of the treatments using natural products are still based on the empirical information.…”