Optimizing oil and xanthorrhizol extraction from Curcuma xanthorrhiza Roxb. rhizome by supercritical carbon dioxide

Salea, Rinaldi; Widjojokusumo, Edward; Veriansyah, Bambang; Tjandrawinata, Raymond R.

doi:10.1007/s13197-014-1272-3

Cited by 34 publications

(28 citation statements)

References 25 publications

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“…Recently, we reported that Taguchi method was able to simplify experimental procedure and maintain experimental cost at minimum level without affecting quality of the result on several optimization studies [23][24][25]. In the present study, optimization and scale-up process for SCFE-CO 2 of Zingiber officinale var.…”

Section: Introductionmentioning

confidence: 76%

“…This was due to an increase in density and solvent power of SC-CO 2 with increased pressure [10,[17][18][19]. Therefore, an increase in CO 2 density accelerated mass transfer of the analytes and solvent during extraction process and improved the extraction yield [17,24]. Previous studies reported that crossover phenomenon was observed at high pressure (above 20 MPa), while extraction temperature was increased [10,26].…”

Section: Laboratory Scale Optimizationmentioning

confidence: 98%

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Optimization and scale-up process for supercritical fluids extraction of ginger oil from Zingiber officinale var. Amarum

Salea¹,

Veriansyah²,

Tjandrawinata³

2017

The Journal of Supercritical Fluids

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Section: Introductionmentioning

confidence: 76%

Section: Laboratory Scale Optimizationmentioning

confidence: 98%

Optimization and scale-up process for supercritical fluids extraction of ginger oil from Zingiber officinale var. Amarum

Salea¹,

Veriansyah²,

Tjandrawinata³

2017

The Journal of Supercritical Fluids

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“…Salea et al (2014) membandingkan efektivitas ekstraksi xantorizol dengan pelarut nheksana dan fluida superkritis CO 2 dan memperoleh informasi bahwa rendemen ekstraksi dengan fluida superkritis CO 2 memberikan rendemen lebih tinggi. Namun demikian, ekstraksi dengan n-heksana dapat menjadi alternatif metode ekstraksi xantorizol.…”

Section: Hasil Dan Pembahasan Ekstrak Rimpang Temulawak Dan Kadar Xanunclassified

Metode Ekstraksi dan Pemisahan Optimum Untuk Isolasi Xantorizol dari Temulawak (Curcuma xanthorrhiza)

2017

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ABSTRAKXantorizol merupakan senyawa penciri utama temulawak (Curcuma xanthorrhiza). Penelitian ini bertujuan menentukan metode ekstraksi dan pemisahan optimum untuk isolasi xantorizol dari rimpang temulawak. Maserasi dan sokletasi digunakan untuk mengekstraksi xantorizol dengan pelarut metanol, dietil eter, dan n-heksana. Pemisahan dilakukan dengan kromatografi kolom dan kromatografi lapis tipis (KLT) preparatif dan hasil pemisahan dikarakterisasi berdasarkan spektrum inframerah dan kromatografi gas-spektrum massa (KG-SM), sementara persentase kemurniannya ditentukan dengan kromatografi cair kinerja tinggi. Ekstrak n-heksana dari teknik maserasi memiliki kandungan xantorizol lebih tinggi dibanding ekstrak lainnya yaitu sebesar 168 mg/g sampel. Fraksi ke-4 hasil pemisahan kolom terhadap ekstrak nheksana memberikan dua spot pada KLT dengan R f 0.54 dan 0.68, spot dengan Rf 0.54 diduga merupakan xantorizol (dikonfirmasi dengan KG-SM). Pemurnian lebih lanjut dengan KLT preparatif terhadap fraksi ke-4 menghasilkan xantorizol dengan rendemen sebesar 0.016 % berdasar bobot sampel dan tingkat kemurnian sebesar 87.40 %.

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“…Pharmacologically-active compounds in plants are usually present in low concentrations. In recent years, our laboratories have developed and investigated various extraction techniques and biological assays on natural products [5][6][7][8]. The most widely-used method is extraction based on organic solvent [9].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the development of more reliable, simpler, less chemical-intensive and less expensive technique is necessary for commercial-scale production. In recent years, supercritical carbon dioxide (SC-CO2) extraction has widely been utilized for the extraction of oil and bioactive compounds from plant materials [8,10]. SC-CO2 extraction offers several advantages due to its non-toxic nature and unique physicochemical properties which include low viscosity, fast diffusion and tunable physical properties with temperature and pressure.…”

Section: Introductionmentioning

confidence: 99%

Supercritical Carbon Dioxide Extraction of Mango Ginger (Curcuma Mangga Roxb.): Process Optimization Using Taguchi Method

Salea¹,

Darussalam²,

Hiendrawan³

et al. 2019

Int J App Pharm

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Objective: Extraction of Curcuma mangga (C. mangga) using supercritical carbon dioxide (SC-CO2 Methods: A Taguchi method with L) was investigated to provide information about the optimum extraction condition. 9 orthogonal array design was used to determine the optimum extraction conditions. Effects of extraction pressure, temperature, CO2Results: The highest C. mangga oil yield (5.223%) from SC-CO flow rate and dynamic extraction time on C. mangga oil yield were investigated at levels ranging between 150-350 bar, 40-60 °C, 10-20 g/min and 120-240 min, respectively. 2 extraction was obtained at a pressure of 350 bar, temperature of 60 °C, CO2 flow rate of 20 g/min and dynamic extraction time of 240 min. The experimental C. mangga oil yield at optimum condition was in a good agreement with the values predicted by computational process using Taguchi method. Based on S/N ratio calculation, the most influencing parameters in maximizing C. mangga oil yield is extraction temperature, followed by extraction pressure, dynamic extraction time and CO2 Conclusion: In this study, Taguchi method was successfully applied to optimize SC-CO flow rate.2 extraction of C. mangga. Taguchi method was able to simplify the experimental procedure of SC-CO2

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Optimizing oil and xanthorrhizol extraction from Curcuma xanthorrhiza Roxb. rhizome by supercritical carbon dioxide

Cited by 34 publications

References 25 publications

Optimization and scale-up process for supercritical fluids extraction of ginger oil from Zingiber officinale var. Amarum

Optimization and scale-up process for supercritical fluids extraction of ginger oil from Zingiber officinale var. Amarum

Metode Ekstraksi dan Pemisahan Optimum Untuk Isolasi Xantorizol dari Temulawak (Curcuma xanthorrhiza)

Supercritical Carbon Dioxide Extraction of Mango Ginger (Curcuma Mangga Roxb.): Process Optimization Using Taguchi Method

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