Induction of autoantibodies and circulating immune complexes in mice after injection of Brucella fraction “ PI ” or inoculation with live Brucella suis

Cannat, A; Escande, Aurélie; Peraldi, F; Serre, A

doi:10.1016/s0769-2625(83)80152-4

Cited by 10 publications

(8 citation statements)

References 15 publications

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“…10 Even more, in mice, a transient induction of autoantibodies and circulating immune complexes have been reported to occur following injection of an extract from Brucella melitensis. 11 In the same way, our patient developed autoimmune phenomena during the infection with Brucella melitensis.…”

Section: Discussionsupporting

confidence: 66%

Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis

Lazcano

Méndez

Santos

2005

Journal of Infection

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Section: Discussionsupporting

confidence: 66%

Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis

Lazcano

Méndez

Santos

2005

Journal of Infection

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“…There is proof [14,15], both by experiments in animals [16] and studies in humans, that Brucella infection can induce a systematic autoimmune response. This autoimmune stimulation randomly results in autoimmune hemolysis and platelet destruction, and such cases tend to present dramatically, with sever hemolysis and hemorrhagic purpura [17,18].…”

Section: Discussionmentioning

confidence: 99%

Immune thrombocytopenia attributed to brucellosis and other mechanisms of Brucella‐induced thrombocytopenia

et al. 2004

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Thrombocytopenia often complicates the course of acute brucellosis, mainly due to bone marrow suppression or hypersplenism. Immune thrombocytopenia is also reported in brucellosis, resulting usually in massive thrombocytopenia, purpura, and spontaneous hemorrhage. We describe a case of acute brucellosis in an 85-year old woman, who presented with fever, purpuric skin lesions, anemia, and rhinorrhagia. The absolute platelet count was 1000/mL. Direct and indirect Coombs tests were positive, and a coldagglutinin was detected. The patient was diagnosed as suffering from brucellosis on the basis of a strongly positive serologic reaction and was treated with doxycycline, streptomycin, and a short course of corticosteroids, with a rapid rise in platelet number. Am.

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“…The initial fall may have been the result of endocytosis of immune complexes by macrophages which have been activated by the infection. The induction of circulating immune complexes by infection with B. suis in mice has also been reported (Cannat et al, 1983).…”

Section: Antigenaemia and Severity Of Infectionmentioning

confidence: 88%

Longitudinal study of brucellosis in mice by immunoassay of lipopolysaccharide-related antigens in blood and urine

Limet

Berbinschi

Cloeckaert

et al. 1988

Journal of Medical Microbiology

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Summary.Immunoassays based on latex agglutination or enzyme labelling (ELISA) were devised for the detection of lipopolysaccharide (LPS) of BrucelZa abortus, or its degradation products, in biological fluids of infected mice. The agglutination of latex was measured by counting of the remaining non-agglutinated particles in an automated immunoassay analyser. LPS was assayed by agglutination with antibodycoated latex and by competitive inhibition of agglutination of LPS-coated latex by anti-LPS antiserum. The inhibition system was more sensitive for the detection of degradation products of LPS. Correlation between ELISA and agglutination inhibition immunoassay was excellent (r = 0.96). Degradation of LPS occurred during storage, particularly when the samples contained specific antibodies. It could be prevented by removing cells immediately after collecting blood samples and by heating or alkaline denaturation of plasma.CBA/H mice were infected with various doses [65-(65 x lo6) cfu] of B. abortus biovar 3 cells and the course of infection followed by immunoassay of LPS-related antigens in serum and urine, and by titration of specific antibodies and non-specific circulating immune complexes. The concentration of LPS degradation products, assayed by the agglutination inhibition assay, was related to the severity of the infection, which was assessed by viable counts of B. abortus in the spleen. A close correlation was observed between the values of antigenaemia, the number of cfu (r = 0.97), and the inoculum size (r = 0.99 at day 28).

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Induction of autoantibodies and circulating immune complexes in mice after injection of Brucella fraction “ PI ” or inoculation with live Brucella suis

Cited by 10 publications

References 15 publications

Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis

Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis

Immune thrombocytopenia attributed to brucellosis and other mechanisms of Brucella‐induced thrombocytopenia

Longitudinal study of brucellosis in mice by immunoassay of lipopolysaccharide-related antigens in blood and urine

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