Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis

Brucella aortitis: the missing link

“…Three types of cutaneous vasculitis have been reported in this context: cryoglobulin-related vasculitis (five cases), leukocytoclastic vasculitis with or without histological features of Henoch-Schonlein purpura (four cases) and one case of septal panniculitis with vasculitis. [7][8][9] In our case, cryoglobulins were not evident nor was immunoglobulin (Ig)A elevated. We considered the possibility of mycotic emboli from the aorta but this was not supported by the negative Brucella PCR from the skin biopsy.…”

Polymicrobial Peritonitis in a Patient with Mixed Cryoglobulinemia

“…Consequently, abdominal computed tomography was performed, demonstrating wall edema of extensive segments of the small bowel, ascending colon, and part of the sigmoid colon, accompanied by vascular engorgement. These finding were compatible with intestinal injuries due to vasculitis of the small blood vessels, favoring bacterial translocation (2,3). The patient did not accept sigmoidoscopy examination.…”

Membranoproliferative glomerulonephritis in a patient with chronic brucellosis

“…On the contrary, the presence of cryoglobulinemia was not recorded in any of the aforementioned cases. It is noteworthy that 4 cases of brucellosis and systemic vasculitis with cryoglobulinemia have been reported [ 13 , 14 ]. Of them, only one patient had impaired renal function with microscopic hematuria and proteinuria, but a renal biopsy was not performed.…”