Immune thrombocytopenia attributed to brucellosis and other mechanisms of <i>Brucella</i>‐induced thrombocytopenia

Pappas, Georgios; Kitsanou, Margarita; Christou, Leonidas; Tsianos, E.V.

doi:10.1002/ajh.10473

Cited by 35 publications

(32 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Infiltration of the bone marrow with solid or hematological malignancies might also result in cytopenias in brucellosis patients [6] . Immune mechanisms have been suggested to be responsible in some cases [5,10] .…”

Section: Discussionmentioning

confidence: 99%

Brucellosis Triggering Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase Deficiency

Pamuk

Çelik²,

Uyanık³

2009

Med Princ Pract

View full text Add to dashboard Cite

Objectives: To present a case of acute brucellosis triggering acute hemolytic anemia in a subject with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Clinical Presentation and Intervention: A 17-year-old male patient presented with fever, malaise and jaundice. His blood and bone marrow cultures yielded Brucella species. In addition, he was found to have acute hemolytic anemia due to previously undiagnosed G6PD deficiency. He was started on folic acid supplementation and given a combination of doxycycline and rifampicin for 6 weeks. His response to antibiotic therapy was optimal; the hemolytic anemia resolved. There were no further episodes of hemolysis. Conclusion: This case showed that the differential diagnosis of acute hemolytic anemia in subjects with G6PD deficiency should include brucellosis, especially in regions where the infection is endemic.

show abstract

Section: Discussionmentioning

confidence: 99%

Brucellosis Triggering Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase Deficiency

Pamuk

Çelik²,

Uyanık³

2009

Med Princ Pract

View full text Add to dashboard Cite

show abstract

“…Bone marrow and the spleen are commonly involved, and such involvement may result in a hypoplastic pattern on the peripheral blood smear [5,6]. Hematological complications of mild anemia and leukopenia have been frequently associated with acute brucellosis, but pancytopenia and thrombocytopenia are less frequently encountered [7,8].…”

Section: Introductionmentioning

confidence: 99%

A multicenter retrospective study defining the clinical and hematological manifestations of brucellosis and pancytopenia in a large series: Hematological malignancies, the unusual cause of pancytopenia in patients with brucellosis

et al. 2007

View full text Add to dashboard Cite

The aim of the study is to review the clinical manifestations and the hematological findings of brucellosis and pancytopenia, with or without hematological malignancies. The records of 202 patients with brucellosis were evaluated retrospectively. Among these cases of brucellosis seen in a 6 year period between April 1999 and June 2005, 30 patients with pancytopenia were identified. The most common manifestation was fever, followed by weight loss, anorexia, malaise, arthralgia, and hepatosplenomegaly. Bone marrow biopsies revealed hypercellularity or normocellularity. The most common findings in the bone marrow evaluation were histiocytic hemophagocytosis and granulomas. Among all cases, we diagnosed 5 hematological malignancies (1 acute myelogenous leukemia, 2 acute lymphoblastic leukemia, and 2 multiple myeloma) concurrently with brucellosis. The clinical symptoms and findings were similar in patients with and without malignancies. In cases with malignancies, the bone marrow biopsy revealed predominant primary disease involvement. Significant increases in ESR and CRP, severe anemia and thrombocytopenia were observed in patients with malignancies. Peripheral blood counts in patients without malignancies returned to normal after antibiotic treatment for brucellosis. However, pancytopenia in two patients with malignancies did not recover because of primary resistant disease. We conclude that while histiocytic hemophagocytosis may be considered as a major cause of pancytopenia, leukemic infiltration can also be an extreme and unusual cause of pancytopenia in patients in whom brucellosis was concurrently diagnosed with hematological malignancies. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.

show abstract

“…The rate of pancytopenia was reported as 3-21% [1]. The possible mechanisms for the thrombocytopenia seen in Brucellosis are hypersplenism, intravascular coagulation, septisemia associated bone marrow suppression, hemophagocytosis and peripheral immunological breakdown of platelets [2]. Brucellosis cases might mimic primary hematological diseases.…”

Section: Discussionmentioning

confidence: 99%

A Case of Brucellosis Admitting with Bleeding

Iris¹,

Şimşek²,

Yıldırmak³

et al. 2016

Med-Science

View full text Add to dashboard Cite

show abstract

Immune thrombocytopenia attributed to brucellosis and other mechanisms of Brucella‐induced thrombocytopenia

Cited by 35 publications

References 13 publications

Brucellosis Triggering Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase Deficiency

Brucellosis Triggering Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase Deficiency

A multicenter retrospective study defining the clinical and hematological manifestations of brucellosis and pancytopenia in a large series: Hematological malignancies, the unusual cause of pancytopenia in patients with brucellosis

A Case of Brucellosis Admitting with Bleeding

Contact Info

Product

Resources

About