Inducible clindamycin resistance among clinical isolates of staphylococci

Ciraj, AM; Vinod, P; Sreejith, G; Rajani, K

doi:10.4103/0377-4929.44963

Cited by 40 publications

(33 citation statements)

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“…Similar results were obtained in a study conducted in India by Ciraj et al 10 where in the MRSA prevalence was 17.3%. The relatively low frequency of MRSA in the present study may be due to the work of the Infection Control Hospital Committee, which has been developing measures to control the use of antibiotics and to implement proper hygienization practices by the hospital staff of HUSM since 2006.…”

Section: Ethical Considerationssupporting

confidence: 79%

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Evaluation of constitutive and inducible resistance to clindamycin in clinical samples of Staphylococcus aureus from a tertiary hospital

Bottega

Rodrigues

Carvalho

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have become common in hospitals and the community environment, and this wide resistance has limited patient treatment. Clindamycin (CL) represents an important alternative therapy for infections caused by S. aureus. Antimicrobial susceptibility testing using standard methods may not detect inducible CL resistance. This study was performed to detect the phenotypes of resistance to macrolides-lincosamides-streptogramin B (MLS B ) antibiotics, including CL, in clinical samples of S. aureus from patients at a tertiary hospital in Santa Maria, State of Rio Grande do Sul, Brazil. Methods: One hundred and forty clinical isolates were submitted to the disk diffusion induction test (D-test) with an erythromycin (ER) disk positioned at a distance of 20mm from a CL disk. The results were interpreted according to the recommendations of the Clinical and Laboratory Standards Institute (CLSI). Results: In this study, 29 (20.7%) of the 140 S. aureus samples were resistant to methicillin (MRSA), and 111 (79.3%) were susceptible to methicillin (MSSA). The constitutive resistance phenotype (cMLS B ) was observed in 20 (14.3%) MRSA samples and in 5 (3.6%) MSSA samples, whereas the inducible resistance phenotype (iMLS B ) was observed in 3 (2.1%) MRSA samples and in 8 (5.8%) MSSA samples. Conclusions: The D-test is essential for detecting the iMLS B phenotype because the early identifi cation of this phenotype allows clinicians to choose an appropriate treatment for patients. Furthermore, this test is simple, easy to perform and inexpensive.

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Section: Ethical Considerationssupporting

confidence: 79%

“…These drugs inhibit bacterial protein synthesis in susceptible organisms by reversibly binding to the 23S ribosomal ribonucleic acid (rRNA) receptor of the 50S ribosomal subunit 10 11 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of constitutive and inducible resistance to clindamycin in clinical samples of Staphylococcus aureus from a tertiary hospital

Bottega

Rodrigues

Carvalho

et al. 2014

Rev. Soc. Bras. Med. Trop.

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“…During the unifying assessment of 278 strains resistant to 17 antibiotics, the infection-dynamics of this iconic notorious pathogen was discernible with the minimum of 28% resistance to vancomycin and the maximum of 97% resistance to gentamicin. Indeed, occurrence of high percentage of resistance to daptomycin at 36% in HA samples is of high clinical concern in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Among 244 clinical isolates of staphylococci reported from Karnataka, India, 13.1% strains had inducible clindamycin resistance with the MLSB phenotype; among them, 10 isolates were MRSA (38.4% of the total MRSA), 16 were MSSA (12.9% of the total MSSA) and 6 were "coagulasenegative staphylococci" or CONS, i.e., 6.3% of the total isolated CONS [17] . In another laboratory from Karnataka, 10% isolates had inducible clindamycin resistance, 9% had constitutive resistance and 8% had MS phenotype.…”

Section: Discussionmentioning

confidence: 99%

“…A heedful univariate analysis of the bivalence of D-test results with several hospital factors such as, sex, presence of comorbidities, etc., vindicates this study. Further, an antibiogram of a spectrum of 278 isolates of S. aureus with 17 antibiotics was obtained that gave an idea on the prevalence of the insidious infection-dynamics and the associated shenanigans of this notorious super-bug of health domain, for a benefit of apothecary in dove-tailing suitable drugs and to decrease unwarranted increases in the growing cost of hospital care, in face of the intimidating erythromycininduced MLSB resistance.…”

Section: Introductionmentioning

confidence: 99%

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