Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus from Sub Himalayan Region of India

Mokta, Kiran; Verma, Santwana; Chauhan, Divya; Ganju, Sunite A; Singh, Digvijay; Kanga, Anil; Kumari, Anita; Mehta, Vinod

doi:10.7860/jcdr/2015/13846.6382

Cited by 19 publications

(26 citation statements)

References 22 publications

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“…In different studies, the inducible clindamycin ranged from 0% to 37.1% [ Table 4 ]. [ 7 12 15 16 17 18 19 20 21 22 23 24 25 26 27 ] It was observed that percentage of inducible clindamycin resistance was higher among MRSA (24.8%) compared to MSSA (7.5%). The difference between MSSA and MRSA isolates were not statistically significant ( P = 0.2340).…”

Section: Discussionmentioning

confidence: 99%

“…[ 15 ] In different studies, authors have reported the MS phenotype varies between 0.7% and 44.6% [ Table 4 ]. [ 7 12 15 16 17 18 19 20 21 22 23 24 25 26 27 ] This result implies that clindamycin can be safely and effectively instituted as a therapeutic option in this group of patients even in the presence of macrolide resistance.…”

Section: Discussionmentioning

confidence: 99%

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Detection of inducible and constitutive clindamycin resistance among Staphylococcus aureus isolates in a tertiary care hospital, Eastern India

et al. 2016

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Introduction:Clindamycin is an excellent drug for skin and soft tissue Staphylococcus aureus infections, but resistance mediated by inducible macrolide-lincosamide-streptogramin B (iMLSB) phenotype leads to in vivo therapeutic failure even though they may be in vitro susceptible in Kirby–Bauer disk diffusion method.Objective:The study was aimed to detect the prevalence of iMLSB phenotype among S. aureus isolates by double disk approximation test (D-test) in a tertiary care hospital, Eastern India.Materials and Methods:A total of 209 consecutive S. aureus isolates were identified by conventional methods and subjected to antimicrobial susceptibility testing by Kirby–Bauer disk diffusion method. Erythromycin-resistant isolates were tested for D-test.Results:From 1282 clinical specimens, 209 nonrepeated S. aureus isolates were obtained. Majority of isolates 129 (61.7%) were methicillin-resistant S. aureus (MRSA). There was statistically significant difference between outpatients 60.1% and inpatients 39.9% (P < 0.0001). From 209 S. aureus isolates, 46 (22%) were D-test positive (iMLSB phenotype), 41 (19.6%) were D-test negative (methicillin sensitive [MS] phenotype), and 37 (17.7%) were constitutively resistant (constitutive macrolide-lincosamide-streptogramin B phenotype). The incidence of inducible, constitutive, and MS phenotype was higher in MRSA isolates compared to MS S. aureus (MSSA). The constitutive clindamycin resistance difference between MSSA and MRSA isolates were found to be statistically significant (P = 0.0086).Conclusion:The study revealed 22% of S. aureus isolates were inducible clindamycin resistant, which could be easily misidentified as clindamycin susceptible in Kirby–Bauer disk diffusion method. Therefore, clinical microbiology laboratory should routinely perform D-test in all clinically isolated S. aureus to guide clinicians for the appropriate use of clindamycin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Detection of inducible and constitutive clindamycin resistance among Staphylococcus aureus isolates in a tertiary care hospital, Eastern India

et al. 2016

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“…A high event of S. aureus strains in IPD setting might be because of comfort in spreading of disease among patients through health care workers and instruments. 7 In this study ( 9%).…”

Section: Discussionmentioning

confidence: 48%

The study of inducible clindamycin resistance & antimicrobial susceptibility pattern of the Staphylococcus aureus isolates from various clinical samples

Patil¹,

Wankhede²

2020

IJMMTD

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Introduction: Staphylococcus aureus is responsible for skin and soft tissue infections, surgical site infections. Macrolidelincosamide-streptogramin B (MLSB) antibiotics particularly clindamycin is favoured agent to treat skin and soft tissue infections cause by Staphylococcus aureus. Broad utilization of these antibiotics has prompted an expansion in resistance against these antimicrobials, requiring the need to recognize such resistance on routine premise utilizing a D test. Aims and Objectives: To study inducible clindamycin resistance & antimicrobial susceptibility pattern of S. aureus isolates. Materials and Methods: 300 isolates of S. aureus from different clinical examples were subjected to antimicrobial susceptibility testing by Kirby Bauer's disc diffusion method. Just erythromycin resistant isolates were subjected for D test to contemplate inducible clindamycin resistance according to CLSI guidelines. Results: Out of 300 isolates, 171 (57%) S. aureus isolates were erythromycin resistant. Among these isolates 84 (28%) showed MS phenotype, 68 (22.66%) showed inducible resistance & 19 (6.33%) showed constitutive resistance. Conclusion: A D test can be utilized to identify inducible clindamycin resistance. This test will help for legitimate treatment of the patients yet additionally counteract misuse of anti-microbial agents.

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“…Its desirable oral bioavailability has been credited as an excellent option for outpatient treatment and changeover after intravenous antibiotics. However, the rate of inducible clindamycin resistance (iCR) (16.2%) requires an urgent response, and has been previously reported elsewhere [44,45]. The consequence of excessive use of macrolides is responsible for raising resistance in this class of antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Highly Resistant Staphylococcus aureus Isolated from Patients Attending a Tertiary Hospital, South Western Uganda

Baguma¹,

Tibyange

Owalla

et al. 2019

MRJI

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Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus from Sub Himalayan Region of India

Cited by 19 publications

References 22 publications

Detection of inducible and constitutive clindamycin resistance among Staphylococcus aureus isolates in a tertiary care hospital, Eastern India

Detection of inducible and constitutive clindamycin resistance among Staphylococcus aureus isolates in a tertiary care hospital, Eastern India

The study of inducible clindamycin resistance & antimicrobial susceptibility pattern of the Staphylococcus aureus isolates from various clinical samples

Highly Resistant Staphylococcus aureus Isolated from Patients Attending a Tertiary Hospital, South Western Uganda

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