Indonesian Sidaguri (Sida rhombifolia L.) as Antigout and Inhibition Kinetics of Flavonoids Crude Extract on the Activity of Xanthine Oxidase

Inhibition Kinetics of <i>Sida rhombifolia</i> L. Extract Toward Xanthine Oxidase by Electrochemical Method

“…The S. Rhombifolia's ethanol extract is known to have inhibitory activity (%) by 13.64% to 82.69% (5-200 mg L -1 ). Iswantini et al [3] previously reported that the inhibitory assay of flavonoid crude extract from this plant using the spectrophotometric . The measurable differences of the inhibition effect in this study and Iswantini et al [3] were presumably because the spectrophotometric measurement which is strongly influenced by the concentration of test solution so that the response becomes less good.…”

“…Iswantini et al [3] previously reported that the inhibitory assay of flavonoid crude extract from this plant using the spectrophotometric . The measurable differences of the inhibition effect in this study and Iswantini et al [3] were presumably because the spectrophotometric measurement which is strongly influenced by the concentration of test solution so that the response becomes less good. It can be indicated that the electrochemical method can respond to the inhibitory activity of extracts better compared to the spectrophotometric method.…”

“…Flavonoids crude extract of S. Rhombifolia was found out to show the competitive inhibition toward XO [3]. Luteolin and quercetin were reported to follow the competitive inhibition against XO [5].…”

“…Sida rhombifolia L. is one of a traditional medicinal plant that has been known with potential as antigout. Iswantini et al [3] reported that flavonoids crude extract of this plant has a high inhibitory activity of XO, ranging from 48 to 71% (100-800 mg L -1 ). Not only in a single composition, Sida rhombifolia L. potential as antigout in the combined formula has a higher inhibitory activity compared to allopurinol, and this result has been patented and has been granted [4].…”

Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifolia

“…8 As a result of the abundant activities of these plants there are also many pharmacological evaluations; their analgesic, 9 antidiarreic, 10 anti--oxidant, vasorelaxant, 11 and anti-hyperglycemic activities, 12 among others, have been tested, mainly from extracts of different species. 7 Previous chemical reports show the presence of ecdysteroids, 13,14 alkaloids, 11,15 and flavonoids, 11,16 as main secondary metabolites in S. acuta and S. rhombifolia.…”