Individual Exposure Load of Formaldehyde and Adolescents’ Organism Sensibilization

Masnavieva, L. B.; Борисовна, Маснавиева Людмила; Kudaeva, Irina V.; Ефимова, Н. В.; Zhurba, O. M.

doi:10.33396/1728-0869-2017-6-3-8

Cited by 5 publications

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“…Formaldehyde in the atmospheric air of low-lying cities is a product of photo-oxidation of hydrocarbons produced as a result of incomplete fuel combustion, and a typical component of smog in low-lying cities. Owing to its high reactive chemical activity, formaldehyde is capable of changing the course and intensity of metabolic processes, causing damage to DNA and protein molecules in human cells [17], having mutagenic, carcinogenic, teratogenic, general toxic, sensitizing and allergenic effects [18]. It is revealed that the content of formaldehyde in the atmospheric air relates to the development frequency of the bronchial asthma [19].…”

Section: Introductionmentioning

confidence: 99%

Hygienic health risk distribution due to atmospheric air pollution in low-lying cities

et al. 2021

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The total excess of components which pollute the atmospheric air of the city of Saratov has been increasing from May to October and is most evident for the locations of transport interchanges. The allocation of polluting components of atmospheric air corresponds to the distribution model of structural basin cities. The hazardous level of non-carcinogenic health risk caused by inhalation of substances polluting the atmospheric air of Saratov (HQ>1) is determined by the existence of nitrogen oxides, hydrogen sulfide, ammonia, and formaldehyde. Non-carcinogenic risk of hazard has a tendency to increase in the warm season – from May to July), as well as in the winter period (January-February). The carcinogenic health risk associated with the existence of formaldehyde in the air exceeds the upper limit of the permissible risk. The highest values of the carcinogenic risk match the monitoring points situated near motorways. This may be due to photochemical processes involving the results of incomplete fuel combustion in engines, in which formaldehyde is formed. The anticipated increase in respiratory morbidity due to chronic inhaled exposure to NO2 in children aged 6-7 years ranges from 44 to 79 percent, while the grow-up rates are higher in girls.

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Section: Introductionmentioning

confidence: 99%

Hygienic health risk distribution due to atmospheric air pollution in low-lying cities

et al. 2021

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“…Загрязнение воздушной среды играет значимую роль в формировании риска нарушения здоровья населения, а экополлютанты способны выступать в качестве аллергенов и сенсибилизирующих агентов и вызывать развитие аллергических заболеваний [3,4]. Доказано, что загрязнение воздуха формальдегидом, бенз(а)пиреном, фенолом, диоксидом азота оказывает влияние на функционирование иммунной системы, вызывая увеличе-ние синтеза провоспалительных цитокинов, снижение содержания IgA, повышение уровней специфических аутоантител, ингибирование гибели клеток по типу апоптоза и активации путем некроза, а также ассоциировано с аллергопатологией у взрослых и детей [5][6][7][8].…”

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“…Для оценки влияния экспозиции химическими соединениями родительского поколения в предгестационный период были использованы данные о профессиональных маршрутах работников и содержании загрязнителей в воздухе рабочей зоны. Информация о содержании химических соединений в воздушной среде была получена из информационных баз Роспотребнадзора Иркутской области, Росгидромета, а также материалов исследований, которые проведены сотрудниками ФГБНУ ВСИМЭИ и представлены в работах [5,9,22,23]. В лонгитюдных исследованиях Н.М.…”

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“…При расчетах персонифицированных HI нарушений в иммунной системе подростков использовали данные о содержании иммунотропных поллютантов в атмосферном воздухе, в воздухе жилых и учебных помещений, а также антропометрические и спирометрические параметры школьников, информацию об их режиме дня [24]. Наибольший вклад в формирование индивидуальных HI нарушений иммунитета вносил формальдегид, его максимальные уровни в учебных помещениях достигали 0,005 мг/м 3 , в жилых -0,006 мг/м 3 , в атмосферном воздухе -0,006 мг/м 3 (референтные уровни -0,003 мг/м 3 ) [5].…”

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“…В РТМЛ использовали лейкоциты, выделенные из цельной крови. При проведении реакции хемокинетическим фактором являлся формальдегид или нитрит натрия, положительным контролем -митоген фитогемагглютинин, интактным контролем -культуральная среда без добавления хематтрактанта[5]. ИМ н соответственно) не выявил значимых различий в зависимости от производственного контакта родителей с химическими веществами в период до рождения ребенка, как в группах в целом, так и в подгруппах с различным HI (табл.…”

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Risk of sensitization to ecopollutants in teenagers with inherited chemical burden

Masnavieva¹,

Efimova²,

Kudaeva³

2021

Health Risk Analysis

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At present allergic diseases are detected in 30% people and their frequency is only growing. A significant role in allergic pathology occurrence belongs to ambient air contamination and chemicals being introduced not only into children’s bodies, but their parents’ ones as well since pollutants can act as allergens and sensitizing agents. Our research goal was to examine influence exerted by parents’ pre-gestation exposure to chemicals on sensitization among teenagers living in an area where ambient air was contaminated. We examined overall immunoglobulin E contents and leukocytes migration inhibition test with formaldehyde and sodium nitrite in 115 teenagers whose parents worked under adverse working conditions at chemical and petrochemical enterprises and in 244 schoolchildren whose parents didn’t have any occupational contacts with chemicals. Each group was divided into sub-groups depending on inhalation chemical burden on schoolchildren’s bodies caused by ambient air contamination and contaminated air indoors (with hazard index (HI) for immune disorders being lower than 2 and HI≥2). The research allowed establishing that teenagers whose parents had worked at chemical and petrochemical enterprises during a pre-gestation period had elevated IgE contents more frequently as well as changes in leukocytes migration inhibition test with formaldehyde; it indicated there was sensitization to this chemical. Parents’ occupational contacts with chemicals led to an increase in relative risks of elevated igE contents and 2.5 times higher sensitization among schoolchildren with HI<2. Risk that sensitization to formaldehyde might occur was equal to 2.3 among senior schoolchildren with HI≥2 whose parents worked at chemical enterprises.

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Application of Mathematical Planning of the Experiment in the Choosing the Optimum Conditions of the Vapor-Phase Gas-Chromatographic Determination of Formaldehyde in the Urine

Alekseenko

Zhurba

2018

HAS

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Introduction. There was substantiated a method for the determination of formaldehyde by vapor-phase gas chromatography by the use of derivatizing reagent o-(2,3,4,5,6-pentafluorbenzyl)hydroxylamine. Material and methods. Formaldehyde in urine was derivatized to o-pentafluorobenzyloxime and recovered to the vapor phase by heating the urine sample with o-(2,3,4,5,6-pentafluorbenzyl)hydroxylamine in a sealed vial. Gas-chromatographic analysis of the vapor-air phase was performed in a mode of the temperature gradient on a capillary column HP-5 with a flame ionization detector. Identification of the analyte in the form of the derivative-o- pentafluorobenzyloxime of formaldehyde was carried out according to the absolute retention time, which was established by comparing the chromatograms of model formaldehyde mixtures in the urine of different concentrations. Results. The optimal conditions for gas extraction are selected using mathematical experimental planning. The most important factors of gas extraction in the vapor-phase analysis are the temperature and time of the establishment of the interphase equilibrium with heating. From the experimentally obtained curves of the analytical signal on the temperature and the heating time, the zero level and the interval of variation of these factors are chosen. A matrix for planning a 2-factor experiment was constructed. The coefficients of the mathematical model are determined. There was carried out statistical processing of the experimental data, which was reduced to the estimation of the reproducibility of the optimization parameter and to the evaluation of the significance of the coefficient of the mathematical model. The adequacy of the mathematical model was evaluated, its interpretation was carried out. Discussion. The peak area of the analyte increases with the elevating the temperature and heating time, due to an increase in the analyte concentration in the vapor phase. Moreover, the heating time makes a greater contribution to the formation of the analytical signal than the temperature. The step of motion along the gradient was calculated and the experiments of steep ascent were carried out. Conclusion. According to the results of the steep ascent experiments, the optimal conditions for the gas extraction of formaldehyde in the form of a derivative were chosen.

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Individual Exposure Load of Formaldehyde and Adolescents’ Organism Sensibilization

Cited by 5 publications

References 1 publication

Hygienic health risk distribution due to atmospheric air pollution in low-lying cities

Hygienic health risk distribution due to atmospheric air pollution in low-lying cities

Risk of sensitization to ecopollutants in teenagers with inherited chemical burden

Application of Mathematical Planning of the Experiment in the Choosing the Optimum Conditions of the Vapor-Phase Gas-Chromatographic Determination of Formaldehyde in the Urine

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