Individual capacity for DNA repair and maintenance of genomic integrity: a fertile ground for studies in the field of assisted reproduction

Vazharova, Radoslava; Kremensky, Ivo

doi:10.1080/13102818.2016.1159923

Cited by 7 publications

(2 citation statements)

References 128 publications

(113 reference statements)

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“…The outcomes after IVF/ICSI in women with endometriosis of all stages are significantly poorer in terms of dosage and duration of gonadotropin treatment, number of oocytes retrieved, fertilisation rate, number of obtained embryos, and number of quality embryos of day 3 post-fertilisation [71]. It has been speculated that the 'pro-repair' tendencies conferred by carriership of the 72Pro allele may increase the risk for ectopic growth of endometrial tissue [72]. Female carriers of the variant (duplication) allele of another common TP53 gene polymorphism -the 16 bp duplication polymorphism were also found to be at significantly increased risk for endometriosis [45].…”

Section: Role Of Individual Repair Capacity In the Constitution Of Thmentioning

confidence: 99%

Reproductive outcomes in pregnant women aged 35 or older: the role of individual repair capacity

Petkova¹,

Dimitrova²,

Zhelev³

et al. 2015

Biodiscovery

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Abbreviations: 8-OH-dG -8-hydroxydeoxyguanosine, AMA -advanced maternal age, AR -assisted reproduction, BER -base excision repair, CDC -US Centre for disease prevention and control, DIC -disseminated intravascular coagulation, DS -Down syndrome, HELLP -haemolysis/elevated liver enzymes/low platelets, ICSI -intracytoplasmic sperm injection, IRC -individual repair capacity, IUGR -intrauterine growth restriction, IUI -intrauterine insemination, IVF -in vitro fertilisation, LIF -leukaemia inhibitory factor, NER -nucleotide excision repair, PCOS -polycystic ovary syndrome, PIH -pregnancy-induced hypertension, ROS -reactive oxygen species, TTD -trichothiodystrophy, w.g. -weeks of gestation, WHO -World Health Organisation, XP -xeroderma pigmentosum. AbstractAt present, childbirth is being progressively postponed until later age. Women aged 35 or older may have to wait longer to conceive than younger women and are more likely to be referred to fertility evaluations, but in a significant proportion a spontaneous conception would be achieved in the timeframe typical of younger women. Pregnancies where mothers are ≥ 35 are associated with more risks for pregnancy loss, chromosomal disease, pregnancy-associated complications, prematurity and low birthweight. These concerns, however, are not uncommon in younger women as well. This puts forward the question whether advanced age per se is the underlying cause for the increased risk for adverse outcomes in older pregnant women, or whether there might be other factors that account for it but do not radically worsen the prospects for favourable outcomes. The individual risks associated with childbirth late in life may stem from maternal genetic background rather than being a simple function of age. There is plenty of preliminary evidence that individual capacity for identification and repair of DNA damage may constitute a major factor in female fertility and fecundity. Subtle deficiencies in the repair capacity may have little to no importance in younger pregnant women but may make a significant difference in older women. The outcomes of pregnancies in women >35 are largely dependent on the prepregnancy health status and the quality of antenatal care, and may not be dramatically different from outcomes in younger women.

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Section: Role Of Individual Repair Capacity In the Constitution Of Thmentioning

confidence: 99%

Reproductive outcomes in pregnant women aged 35 or older: the role of individual repair capacity

Petkova¹,

Dimitrova²,

Zhelev³

et al. 2015

Biodiscovery

View full text Add to dashboard Cite

show abstract

“…Evidently, fragmentation in the sperm DNA may be repaired, but only to a certain extent. The cut-off value of sperm damage beyond which the zygote would not survive may be different in different species ( 15 ). It has become a current social trend for women to delay childbearing.…”

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confidence: 99%