Indices of renal tubular function in perinatal asphyxia

Willis, Frank; Summers, Julie; Minutillo, Corrado; Hewitt, Ian K.

doi:10.1136/fn.77.1.f57

Cited by 31 publications

(26 citation statements)

References 13 publications

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“…Perinatal asphyxia is known to have deleterious effects on all body systems, namely central nervous system (CNS), kidneys and gut. It is probably the primary cause of transient renal impairment or acute renal failure (ARF) in neonates [2]. Renal injury as a consequence of decreased perfusion of the kidney may result from circulatory adaptive responses to perinatal asphyxia [3,4].…”

Section: Introductionmentioning

confidence: 99%

Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia—a study in a developing country

Bakr

2005

Pediatr Nephrol

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Renal damage frequently complicates perinatal asphyxia. Renal vasoconstriction due to adenosine metabolite leads to a fall in glomerular filtration rate (GFR) and filtration fraction. This might be inhibited by the nonspecific adenosine receptor antagonist, theophylline. This study was designed to determine whether theophylline could prevent and/or ameliorate renal dysfunction in term neonates with perinatal asphyxia. We randomized 40 severely asphyxiated term infants to receive intravenously a single dose of either theophylline (5 mg/kg; study group: n=20) or placebo (control group: n=20) during the first hour of life. Fluid intake, urine output, serum creatinine, creatinine clearance, GFR, urinary beta2 microglobulin (beta2 M) and sodium excretion were recorded during the first 5 days of life. The two groups were comparable. No significant difference was reported regarding mechanical ventilatory support, respiratory complications and seizures. Severe renal dysfunction was significantly higher in the control group. Serum creatinine values were less, and creatinine clearance and GFR were significantly higher in the theophylline group from the second day onwards. beta2 M excretion was significantly less in the theophylline group, while sodium excretion and hematuria showed no significant difference. Prophylactic theophylline treatment, given early after birth, has beneficial effects in reducing the renal involvement in asphyxiated full-term infants, with no significant changes in central nervous system involvement.

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Section: Introductionmentioning

confidence: 99%

Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia—a study in a developing country

Bakr

2005

Pediatr Nephrol

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“…The urinary β 2 -MG level in the urine obtained within 48 h after birth was significantly higher in the CAM group than in the non-CAM group in PT [23][24][25][26] and PT 27-28 (p=0.0018 and p=0.0101 respectively). However, there were no differences in PT [29][30] , PT 31-32 , and PT [33][34] . In addition, the urinary β 2 -MG level at 7 days of age was similar between the CAM group and the non-CAM group in all five groups and there were no significant differences.…”

Section: Patientsmentioning

confidence: 88%

“…The significantly elevated urinary β 2 -MG levels seen in highly premature neonates disappeared by 1 week after birth. In addition, we analyzed 24 neonates with funisitis as a separate group and their urinary ß 2 -MG levels were 20.7(×10 4 μg/gCr) in PT 23-26 , 13.9 in PT 27-28 , 6.9 in PT [29][30] , and 6.7 in PT 31-32 respectively. There was no particular tendency toward high β 2 -MG levels in the neonates with funisitis.…”

Section: Patientsmentioning

confidence: 99%

“…However, there have only been a few studies on urinary β 2 -MG in neonates [23][24][25][26][27][28][29][30] and very prematurely born infants were only a portion of the subjects in those studies [24,27]. We included very prematurely born infants in this study as the primary subjects for the first time to the best of our knowledge, and focused our attention on how prenatal inflammation and prematurity influence their urinary β 2 -MG level.…”

Section: Introductionmentioning

confidence: 98%

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Urinary ß2-microglobulin in very preterm neonates with chorioamnionitis

et al. 2011

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It is important to identify premature infants with prenatal inflammation as it contributes to short- and long-term complications. Our object was to study how prenatal inflammation affects the urinary β(2)-microglobulin (β(2)-MG) level. Preterm neonates were divided based on the presence of chorioamnionitis (CAM) into the CAM (n = 100) and non-CAM groups (n = 117). These were further subdivided into five groups each: 30 preterm neonates of 23-26; 42 neonates of 27-28; 54 neonates of 29-30; 51 neonates of 31-32; and 40 neonates of 33-34 weeks' gestation. The urinary β(2)-MG level within 48 h of birth was significantly higher in the CAM group than in the non-CAM group among the neonates of 23-26 weeks' gestation (18.3 ± 6.9 vs 10.0 ± 5.6 × 10(4) μg/gCr, p = 0.0018) and the neonates of 27-28 weeks' gestation (16.2 ± 10.8 vs 8.8 ± 3.3 × 10(4) μg/gCr, p = 0.0101). However, there was no difference in urinary β(2)-MG level between the CAM and the non-CAM group among the neonates ≥ 29 weeks 'gestation. Moreover, the elevated urinary β(2)-MG level in the neonates ≤ 28 weeks ' gestation with CAM had disappeared by 1 week after birth. The reasons for the increase in urinary β(2)-MG level within 48 h of birth in very preterm neonates (≤ 28 weeks' gestation) with CAM are believed to be not only prematurity, but also prenatal inflammation. It is suggested that the urinary β(2)-MG level during the early postnatal period can identify prenatal inflammation.

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“…18 Pada penelitian ini didapatkan rerata kadar ureum serum kelompok bayi normal 28,8 mg/dl, asfiksia ringan sedang 31,0 mg/dl dan asfiksia berat 41,3 mg/dl. Rerata kadar ureum serum ketiga kelompok berbeda secara bermakna (p<0,001), hal ini menggambarkan terdapat pengaruh asfiksia terhadap peningkatan kadar ureum.…”

Section: Diskusiunclassified

Hubungan Asfiksia Neonatorum dengan Gangguan Fungsi Ginjal pada Bayi Baru Lahir

Umboh¹

2016

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Asfiksia neonatorum merupakan problem kesehatan pada bayi baru lahir yang dapat menyebabkan gagal ginjal akut jika tidak ditangani dengan baik. Tujuan: untuk mengetahui hubungan antara derajat asfiksia neonatorum dengan derajat gangguan fungsi ginjal Metoda: penelitian analitik observasional pada bayi baru lahir di bangsal Neonatologi Bagian IKA/RSUP Manado antara bulan Agustus 1997-Februari 1998 yang memenuhi kriteria dilakukan pengukuran kadar ureum dan kreatinin serum serta penentuan laju filtrasi glomerulus (LFG). Data dianalisis dengan uji Anova dan Chi-Square. Hasil: di antara 129 bayi baru lahir yang memenuhi kriteria terdiri dari 49 bayi sehat, 50 asfiksia ringan-sedang, dan 30 asfiksia berat. Terdapat perbedaan bermakna kadar serum ureum dan kreatinin serta LFG antara kelompok bayi sehat dengan asfiksia berat dan antara kelompok asfiksia ringan-sedang dengan asfiksia berat (p<0,01). Lima dari 30 kasus asfiksia berat mengalami gagal ginjal akut dan terdapat hubungan bermakna antara derajat asfiksia dengan derajat gangguan fungsi ginjal (p<0,01). Kesimpulan: terdapat perbedaan antara kadar ureum dan kreatinin serum serta LFG antara bayi asfiksia berat dengan bayi sehat dan asfiksia ringan-sedang. Terdapat pula hubungan antara derajat asfiksia dengan derajat gangguan fungsi ginjal.Kata kunci: bayi baru lahir -asfiksia -gangguan fungsi ginjal Sari

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Indices of renal tubular function in perinatal asphyxia

Cited by 31 publications

References 13 publications

Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia—a study in a developing country

Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia—a study in a developing country

Urinary ß2-microglobulin in very preterm neonates with chorioamnionitis

Hubungan Asfiksia Neonatorum dengan Gangguan Fungsi Ginjal pada Bayi Baru Lahir

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