Sepsis is the organ dysfunction resulting from an infection associated with an
unregulated host inflammatory response, which generates high mortality rates in
Brazil. The aim of this stydy was to analyze the trend of early, late and
post-neonatal mortality rates due to sepsis in Brazilian regions, from 2009 to
2018. This is an ecological study of time series. The trend of infant mortality
from sepsis was analyzed using the International Classification of Diseases
(ICD10) according to the place of residence (North, Northeast, Southeast, South
and Midwest). Death Certificate data were collected from the Mortality
Information System database. The temporal trend was analyzed using the
Prais-Winsten estimate, interpreted as increasing, decreasing or stable, through
the dependent variable (logarithm of mortality rates) and interdependent
variables (years of the historical series). The Stata 14.0 statistical software
was used. There were 39,867 infant deaths due to sepsis (78.67% for unspecified
bacterial sepsis of the neonate ). Most of the children were male, had mixed
ethnicity (black and white) , were born preterm with low birth weight and most
mothers were 20-34 years old. There were decreasing trends in mortality rates
from 2009 to 2018: early neonatal, in the Southeast (-3.57%), North (-3.33%) and
South (-2.91%); late neonatal, in the South (-4.12%), Southeast (-4.53%), North
(-4.55%) and Midwest (-6.21%); and post-neonatal, in the Northeast (-1.84%),
North (-3.62%), Southeast (-3.83%) and Midwest (-5.81%). The Northeast showed a
stable trend in early and late neonatal mortality rates. It was concluded that
most regions showed a decreasing trend in mortality rates from sepsis in all age
components, despite regional differences.