Indication of increased phase coupling between theta and gamma EEG rhythms associated with the experience of auditory verbal hallucinations

Koutsoukos, Elias; Angelopoulos, Elias; Maillis, Antonis; Papadimitriou, George N.; Stefanis, Costas N.

doi:10.1016/j.neulet.2012.12.005

Cited by 25 publications

(17 citation statements)

References 30 publications

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“…Koutsoukos et al investigated altered coupling between theta and gamma EEG rhythms to be associated with the experience of AVH. The average differences of theta-gamma-coupling between hallucinatory and resting stages were significant in the left temporal area (Koutsoukos et al, 2013). Kindler et al demonstrated the shortening of class D microstates during AVH (Kindler et al, 2011).…”

Section: Eeg-based Connectivity Analysesmentioning

confidence: 99%

Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

Ćurčić‐Blake

Ford

Hubl

et al. 2017

Progress in Neurobiology

176

155

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HighlightsThe language, auditory and memory/limbic networks are of particular relevance for auditory verbal hallucinations.An increased interaction among the auditory-language and striatal brain regions occurs while patients hallucinate.Fronto-temporal connections are often altered in AVH individuals, but there is no consensus regarding increase or decrease.Connections of the interhemispheric auditory pathway are stronger for first episode patients, but they are weaker in chronic patients.The majority of studies support hybrid AVH hypotheses in which all three networks and the striatal network are involved.

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Section: Eeg-based Connectivity Analysesmentioning

confidence: 99%

Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

Ćurčić‐Blake

Ford

Hubl

et al. 2017

Progress in Neurobiology

176

155

View full text Add to dashboard Cite

show abstract

“…Consistent with this observation, selective blockade of NMDA-R activity in the intrinsic circuitry of the rodent hippocampus (i.e., upstream area CA3) results in reduced feed-forward activation of interneurons along with a somewhat inflexible internally-driven neural representation of the external space in CA1 (133). While there are tantalizing early studies of cross-frequency coupling in schizophrenia (134–136), these studies have not yet produced clear implications for pathophysiology, symptoms and functional impairment, or treatment.…”

Section: Deficits In Temporal Tuning Of Cortical Activity: Ensemblesmentioning

confidence: 99%

Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective

Krystal

Antičević

Yang

et al. 2017

Biological Psychiatry

168

129

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The functional optimization of neural ensembles is central to human higher cognitive functions. When the functions through which neural activity is tuned fail to develop or break down, symptoms and cognitive impairments arise. This review will consider ways that disturbances in the balance of excitation and inhibition might develop and be expressed in cortical networks in association with schizophrenia. This presentation will be framed within a developmental perspective that begins with disturbances in glutamate synaptic development in utero. It will consider developmental correlates and consequences including compensatory mechanisms that increase intrinsic excitability or reduce inhibitory tone. It will also consider the possibility that these homeostatic increases in excitability have potential negative functional and structural consequences. These negative functional consequences of disinhibition may include reduced working memory-related cortical activity associated with the downslope of the “inverted-U” input-output curve, impaired spatial tuning of neural activity and impaired sparse coding of information, deficits in the temporal tuning of neural activity and its implication for neural codes, and conclude by considering the functional significance of noisy activity for neural network function. This presentation will draw on computational neuroscience and pharmacologic and genetic studies in animals and humans, particularly those involving NMDA glutamate receptor antagonists, to illustrate principles of network regulation that give rise to features of neural dysfunction associated with schizophrenia. While this presentation focuses on schizophrenia, the general principles outlined in this review may have broad implications for considering disturbances in the regulation of neural ensembles in psychiatric disorders.

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“…Angelopoulos et al reported an increase in phase synchrony in the alpha band of the auditory cortex before and during the onset of auditory hallucinations. Moreover, increased phase‐phase coupling between theta and gamma in fronto‐temporal areas and the temporal electrode T7, indicating the auditory cortex, was observed during the experience of auditory hallucinations . This suggests that the abnormal coupling of auditory cortical resting state activity to other regions/networks such as CEN may be temporally mediated by abnormally increased phase synchrony.…”

mentioning

confidence: 91%

“…The resting state activity can also be characterized by fluctuations in different frequency bands, ranging from infraslow (0.0001-0.1 Hz) over delta (1)(2)(3)(4), theta (5-8 Hz), alpha (8)(9)(10)(11)(12) and beta (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) to gamma (30-180 Hz). These different frequency bands are coupled with each other (5), constituting a complex temporal structure (6).…”

mentioning

confidence: 99%

Is schizophrenia a spatiotemporal disorder of the brain's resting state?

Northoff

2015

World Psychiatry

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Indication of increased phase coupling between theta and gamma EEG rhythms associated with the experience of auditory verbal hallucinations

Cited by 25 publications

References 30 publications

Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

Interaction of language, auditory and memory brain networks in auditory verbal hallucinations

Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective

Is schizophrenia a spatiotemporal disorder of the brain's resting state?

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