Incremental benefits of EEG informed fMRI in the study of disorders related to meso-corticolimbic dopamine pathway dysfunction: A systematic review of recent literature

Nasser, Nisha Syed; Ibrahim, Buhari; Sharifat, Hamed; Rashid, Aneesa Abdul; Suppiah, Subapriya

doi:10.1016/j.jocn.2019.03.054

Cited by 5 publications

(6 citation statements)

References 69 publications

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“…The combined acquisition of EEG and fMRI was originally developed with a clinical interest to investigate the neuronal activity and the hemodynamic response simultaneously to try to detect and localize epileptic discharges (Rosenkranz and Lemieux, 2010; Huster et al, 2012; Vitali et al, 2015). In the recent years, however, EEG-fMRI became a promising techniques also in experimental neuroscience, in psychiatric and behavioral disorders related to mesocorticolimbic dopamine pathway dysfunction, such as attention-deficit hyperactivity disorder or schizophrenia, in narcolepsy, and in neurodegenerative disorders, such as Alzheimer’s disease (Boecker et al, 2014; Lei et al, 2014; Schneider et al, 2015; Drissi et al, 2016; Brueggen et al, 2017; Syed Nasser et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study

Evangelisti

Pittau²,

Testa

et al. 2019

Front. Neurosci.

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Studies of functional neurosurgery and electroencephalography in Parkinson’s disease have demonstrated abnormally synchronous activity between basal ganglia and motor cortex. Functional neuroimaging studies investigated brain dysfunction during motor task or resting state and primarily have shown altered patterns of activation and connectivity for motor areas. L-dopa administration relatively normalized these functional alterations. The aim of this pilot study was to examine the effects of L-dopa administration on functional connectivity in early-stage PD, as revealed by simultaneous recording of functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) data. Six patients with diagnosis of probable PD underwent EEG-fMRI acquisitions (1.5 T MR scanner and 64-channel cap) before and immediately after the intake of L-dopa. Regions of interest in the primary motor and sensorimotor regions were used for resting state fMRI analysis. From the EEG data, weighted partial directed coherence was computed in the inverse space after the removal of gradient and cardioballistic artifacts. fMRI results showed that the intake of L-dopa increased functional connectivity within the sensorimotor network, and between motor areas and both attention and default mode networks. EEG connectivity among regions of the motor network did not change significantly, while regions of the default mode network showed a strong tendency to increase their outflow toward the rest of the brain. This pilot study provided a first insight into the potentiality of simultaneous EEG-fMRI acquisitions in PD patients, showing for both techniques the analogous direction of increased connectivity after L-dopa intake, mainly involving motor, dorsal attention and default mode networks.

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Section: Introductionmentioning

confidence: 99%

L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study

Evangelisti

Pittau²,

Testa

et al. 2019

Front. Neurosci.

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“…However, it is remarkable that such an association was not present at rest in our sample. TBR is an EEG index of executive control that is widely used (Arns et al, 2013 ; Angelidis et al, 2016 ; Syed Nasser et al, 2019 ). The ratio of theta band power (4–8 Hz) and beta band power (15–30 Hz) is thought to reflect cortical-subcortical interactions (Schutter and Van Honk, 2005 ; Arns et al, 2013 ), so that increased frontal TBR might result from a greater need for top-down control over subcortical structures (i.e., due to the triggering of inappropriate automatic responses).…”

Section: Discussionmentioning

confidence: 99%

“…In this vein, electroencephalography (EEG) constitutes an adequate technique that provides high temporal resolution and distinct indexes of brain activity, allowing for the formulation of specific hypotheses. Hence, because grit has a strong self-regulation component and because its expression has been linked to activity in the PFC, we focused on a widely used executive control index: the frontal theta/beta ratio (TBR) (Putman et al, 2010 , 2014 ; Angelidis et al, 2016 ; Syed Nasser et al, 2019 ). TBR is thought to reflect prefrontally-mediated attentional control and has broadly been used as a biomarker for impulsiveness-related disorders, such as the attention-deficit hyperactivity disorder (Barry et al, 2003 ; Snyder and Hall, 2006 ; Lansbergen et al, 2007 ; Arns et al, 2013 ; Zhang et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological Prints of Grit

et al. 2021

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While scientific interest in understanding the grit trait has grown exponentially in recent years, one important gap in the grit literature relates to its biological and neural substrate. In the present study, we adopted a hypotheses-driven approach in a large sample of young adults (N = 120) with diverse educational backgrounds and work experiences in order to investigate the electrophysiological correlates of grit both during rest and while performing a learning task. Additionally, we selected a measure of impulsiveness to better understand the neural similarities and differences between grit and related self-control constructs. Based on previous work that implicated the prefrontal cortex in grit, we hypothesized that high grit participants would have lower frontal theta/beta ratio (a broadly used index that reflects prefrontally-mediated top–down processes, which might indicate better control over subcortical information). Furthermore, we expected the perseverance of effort facet of grit to be linked to higher complexity during task engagement because previous research has shown complexity indexes (entropy and fractal dimension) to be linked to effort while performing cognitive tasks. Our results revealed that although there were no differences at rest as a function of grit, the participants with high grit and high consistency of interest scores exhibited lower frontal theta/beta ratios during the learning task. This pattern suggests that individual differences in grit might be more evident when top-down control processes are at work. Furthermore, there was a positive association between perseverance of effort and entropy at task, which might indicate more effort and engagement in the task. Finally, no association was found between the neural indexes (frontal theta/beta ratio, entropy, or fractal dimension) and impulsiveness, neither impulsiveness mediated between grit and brain measures. Finally, when controlling for impulsiveness and demographic variables (gender, age, education, and work experience) the effects at the facet level remained statistically significant. While there is still a long way to fully understand the neural mechanisms of grit, the present work constitutes a step toward unveiling the electrophysiological prints of grit.

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“…Systems neurophysiology: multimodal integrative monitoring of neural activity at different spatial and temporal scales Systems neurophysiology, as defined here, aims to integrate structural and functional brain activity features across different spatio-temporal scales to generate a functional atlas of neural activities throughout development and aging and in health and disease (Figure 2) [98]. Examples include the reconstruction of the hierarchical organization of the brain in young and aged individuals with normal cognitive/motor functions [99,100] and in several neurological or psychiatric diseases, including AD [101][102][103][104], PD and parkinsonism [105], and schizophrenia [106,107].…”

Section: Systems Biology: An Overviewmentioning

confidence: 99%

The foundation and architecture of precision medicine in neurology and psychiatry

Hampel

Gao

Cummings

et al. 2023

Trends in Neurosciences

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Incremental benefits of EEG informed fMRI in the study of disorders related to meso-corticolimbic dopamine pathway dysfunction: A systematic review of recent literature

Cited by 5 publications

References 69 publications

L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study

L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study

Electrophysiological Prints of Grit

The foundation and architecture of precision medicine in neurology and psychiatry

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