Increasing risk of diabetes mellitus according to liver function alterations in electronic workers

Lee, Kyung Ho; Han, Joohee; Kim, Soo-Geun

doi:10.1111/jdi.12202

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…The high cholesterol level may be attributed to the presence of hypertension for diabetic conditions which however may be contributory factor in the prevalence of dyslipidemia in type 2 DM. This result agrees with the reports of Harris (2005) and Kyoungho et al (2014), who reported that high cholesterol presence in plasma of diabetic experimental animals treated with plant extract confirms the rise in blood pressure for animals that are diabetic. (Han et al, 2012).…”

Section: Resultssupporting

confidence: 93%

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Effect of a tropical plant (Hunteria umbellata) in the management of Streptozotocin induced Diabetes Mellitus and other physiological and biochemical functions in Wistar

Okolafor¹,

Ekhaise²

2021

Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)

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Hunteria umbellata seeds, leaves and root are used as decoctions in Western and Southern part of Nigeria for the treatment of blood related ailments. The antidiabetic effect of Hunteria umbellata extracts (aqueous and methanol) on hematological, lipid profile and biochemical parameters in streptozotocin-induced diabetes in female Wistar rats was studied. The qualitative phytochemical screening of the seed extracts was determined using standard chemical methods. Twenty five Wistar rats weighing between 117 g and 170 g were shared into five groups of five animals per group for the physiological studies. All treatment groups were administered 500 mg/kg per body weight of H. umbellata extracts. Group I; normal control, Group II; negative or diabetic control, Group III; metformin + streptozotocin (STZ), Group IV; aqueous extract of H. umbellata + STZ and Group V; methanol extract of H. umbellata + STZ. Diabetes was induced with 55 mg/kg body weight STZ. Qualitative phytochemical screening of aqueous and methanol seed extracts of H. umbellata revealed the presence of secondary metabolites such as saponins, phytate, oxalate, anthraquinones, cyanogenic glycoside, phenols and alkaloids were recorded highest concentrations in both extracts. The hypoglycaemic studies of methanol extract revealed significant (p<0.005) reduction on the fasting blood glucose levels of experimental animals for Group V compared to moderate reduction in Group III. Group IV recorded increase in the blood glucose levels of Wistar rats. The haematological parameters were not significant (p>0.05) for all treatment groups. Group V recorded significance (p<0.05) amount of high density lipoproteins (HDL), total cholesterol (CHOL), triglyceride (TRIG) and low density lipoproteins (LDL) while CHOL was significant (p<0.05) for Group III. The biochemical parameters were within safe limit. The methanol extract of H. umbellata possesses the potentials for the managements of blood glucose levels and other physiological and biochemical functions compared to conventional drug (Metformin).

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Section: Resultssupporting

confidence: 93%

“…ALT showed significance (p<0.05) decrease for Group V while AST and ALP were not statistically significant for Group I to group IV. The result of ALT, ALP and ALP for Group I to Group V were within safe limits (Kyoungho et al, 2014;Harris, 2005).…”

Section: Resultsmentioning

confidence: 66%

Effect of a tropical plant (Hunteria umbellata) in the management of Streptozotocin induced Diabetes Mellitus and other physiological and biochemical functions in Wistar

Okolafor¹,

Ekhaise²

2021

Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)

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“…It has been revealed by previous epidemiological studies that impaired liver function (evaluated by increased activity of liver enzyme, for example, alanine aminotransferase) is associated with progression of metabolic disorders. [1,2] Previous prospective studies demonstrates that Insulin resistance (IR) contributed to progression of many metabolic disorders like hypertension, central obesity, and dyslipidemia. [3][4][5] Recently, emerging researches also proposed that IR might also take a role in the development of impaired liver function.…”

Section: Introductionmentioning

confidence: 99%

Association between triglyceride glucose index and abnormal liver function in both urban and rural Chinese adult populations

Cai

Qin

et al. 2019

Medicine

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The purpose of this study was to investigate the association between triglyceride glucose (TyG) index and abnormal liver function both in urban and rural Chinese adult populations. The 5824 urban (Nanjing) and 20,269 rural (Hefei) Chinese adults, from random selected households provided clinical history, glucose, lipids, anthropometric, and blood pressure measurements. Liver functions were assessed using Alanine Aminotransferase (ALT). Linear regression was applied to examine the dose-response relationship between TyG index and ALT. Logistic regression was used to estimate the association between TyG index and abnormal liver and function. Cubic spline models were applied to investigate the dose-response association between TyG index and abnormal liver function. C-statistics was used to compare the discriminable capacity over triglyceride, glucose and TyG index. Linear doseresponse relationship was identified between TyG index and ALT as 1.222 IU increase by 1 unit increase of TyG index (1.242 for urban population and 1.210 for rural population). The 6.0% of urban and 11.0% of rural Chinese adults were observed to have abnormal liver function. The linear association between TyG index and abnormal liver function was revealed as 2.044 (1.930 to 2.165) of odds ratio by in unit increase of TyG index (2.334 for urban population and 1.990 for rural population). Higher C-statistics was found for TyG index compared with fasting glucose and triglyceride both in Chinese urban and rural populations. This study suggested in both urban and rural Chinese adult populations, TyG index is associated with abnormal liver function. TyG index is a potential indicator to identify high-risk individuals with metabolic disorders, for example impaired liver function in Chinese population, especially in Chinese urban population.Abbreviations: ALT = alanine aminotransferase, CAC = coronary artery calcification, IR = insulin resistance, OR = odds ratio, TyG index = triglyceride glucose index.

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“…Liver enzymes, the most common markers of liver function in the clinic, include alanine transaminase (ALT) and aspartate aminotransferase (AST) 5–7. Related studies suggested that the elevation of liver enzymes levels was indicative of insulin sensitivity reduction, insulin resistance and type 2 diabetes development 8–10. Fasting plasma glucose (FPG) is the most commonly used index to monitor the occurrence of early type 2 diabetes, which is of great significance in the prevention of diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…Fasting plasma glucose (FPG) is the most commonly used index to monitor the occurrence of early type 2 diabetes, which is of great significance in the prevention of diabetes. Although previous studies have reported that liver enzymes levels were significantly associated with FPG levels,3 10 11 the evidence remained insufficient, because the reported results were inconsistent in terms of the population studied, such as populations from different regions and populations with different body mass indexes (BMIs). In addition, as we know, almost all related studies regarded BMI as only a covariate in the investigation of the relationship between liver enzymes levels and FPG levels in the general population, and few studies were conducted in Southern China.…”

Section: Introductionmentioning

confidence: 99%

Association of liver enzymes levels with fasting plasma glucose levels in Southern China: a cross-sectional study

Huang

Guo

et al. 2019

BMJ Open

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ObjectiveAccording to several studies, liver enzymes levels are associated with fasting plasma glucose (FPG) levels. However, the association stratified by body mass index (BMI) remains to be elucidated, especially in Southern China. Therefore, the aim of this study was to investigate the correlation between liver enzymes levels and FPG levels stratified by BMI in Southern China.DesignCross-sectional study.Participants and setting3056 individuals participated in real-time interviews and blood tests in Southern China. Participants were divided into three groups (underweight, normal weight and overweight or obesity) based on BMI cut-offs.Main outcome measuredPartial correlation analysis was performed to investigate the relationship between FPG levels and liver tests. Multivariate logistic regression analyses were applied to calculate the adjusted ORs for FPG levels based on liver enzymes levels.ResultsThere was no association between liver enzymes and FPG either in the underweight group or in the normal weight group; however, a significant correlation was observed in the overweight or obesity group (alanine transaminase (ALT), p<0.01; aspartate aminotransferase (AST), p<0.05). After adjusting for confounding factors, the highest tertiles of ALT still remained significantly positively related to FPG levels in the overweight or obesity group, with an OR of 2.205 (95% CI 1.442 to 3.371) for the 5.56≤FPG<7.00 mmol/L vs the FPG<5.56 mmol/L group and with an OR of 2.297 (95% CI 1.017 to 5.187) for the FPG≥7.00 mmol/L vs the FPG<5.56 mmol/L group, but this correlation was not found for AST.ConclusionsThe association of liver enzymes levels with FPG levels differed based on different BMI cut-offs. ALT levels were significantly positively associated with FPG levels in the overweight or obesity group, but not in the other two groups; AST levels were not associated with FPG levels in any group.

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Increasing risk of diabetes mellitus according to liver function alterations in electronic workers

Cited by 7 publications

References 22 publications

Effect of a tropical plant (Hunteria umbellata) in the management of Streptozotocin induced Diabetes Mellitus and other physiological and biochemical functions in Wistar

Effect of a tropical plant (Hunteria umbellata) in the management of Streptozotocin induced Diabetes Mellitus and other physiological and biochemical functions in Wistar

Association between triglyceride glucose index and abnormal liver function in both urban and rural Chinese adult populations

Association of liver enzymes levels with fasting plasma glucose levels in Southern China: a cross-sectional study

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